Signalling pathways in acute oxygen sensing. : [editors Derek J. Chadwick and Jamie Goode].

Format:

Book

Contributor:

Chadwick, Derek.

Goode, Jamie.

Novartis Foundation.

Series:

Novartis Foundation symposium ; 272.

Novartis Foundation symposium ; 272

Language:

English

Subjects (All):

Oxygen in the body--Congresses.

Oxygen in the body.

Oxygen Consumption--physiology.

Hyperoxia--physiology.

Medical Subjects:

Oxygen Consumption--physiology.

Hyperoxia--physiology.

Genre:

Conference papers and proceedings.

Physical Description:

xi, 288 pages : illustrations ; 24 cm.

Place of Publication:

Chichester ; Hoboken, N.J. : John Wiley, 2006.

Summary:

Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mechanisms. Some favour the view that the primary signalling event is a reduction in cell redox state and reactive oxygen species (ROS) due to general inhibition of the electron transport chain (ETC); others support a key role for complex III of the ETC and an increase in ROS generation, while others doubt either of these components is the key intermediary. All these hypotheses are discussed in the book, together with conceptual problems concerning the ability of mitochondria to respond to physiological hypoxia.

The other area of controversy covered in the book is the identity of the endpoint effector(s). Some authors favour K[superscript +] channel inhibition, followed by depolarization and Ca[superscript 2+] entry via L-type channels, while others propose that release of Ca[superscript 2+] from intracellular stores, or capacitative Ca[superscript 2+] entry and other voltage-independent pathways may be more important. The book also describes evidence for an endothelium-dependent Ca[superscript +]-sensitizing pathway involving Rho and possibly other kinases.

While some of these differences can be attributed to variation between tissues, many must be related to differences in interpretation or methodology. In this book, experts in the field of acute oxygen sensing working in different tissues address these controversies and their possible origins, and discuss possible approaches for resolving these controversies. The book will be of great interest to all those working in fields where oxygen sensing is important, particularly cancer and wound healing, as well as researchers in drug discovery and biotechnology.

Contents:

Symposium on Signalling pathways in acute oxygen sensing, held at the Novartis Foundation, London, 25-27 January 2005

Editors: Derek J. Chadwick (Organizer) and Jamie Goode

This symposium is based on a proposal made by Jeremy Ward

/ Michael Duchen Chair's introduction 1

/ Gregg L. Semenza, Larissa A. Shimoda, Nanduri R. Prabhakar Regulation of gene expression by HIF-1 2

/ Ineke P. Stolze, David R. Mole, Peter J. Ratcliffe Regulation of HIF: prolyl hydroxylases 15

/ Daniel Peet, Sarah Linke Regulation of HIF: asparaginyl hydroxylation 37

/ Jose Lopez-Barneo, Patricia Ortega-Saenz, Jose I. Piruat, Maria Garcia-Fernandez Oxygen-sensing by ion channels and mitochondrial function in carotid body glomus cells 54

/ Keith J. Buckler, Beatrice A. Williams, Rodrigo Varas Orozco, Christopher N. Wyatt The role of TASK-like K[superscript +] channels in oxygen sensing in the carotid body 73

/ Nanduri R. Prabhakar, Ying-Jie Peng, Guoxiang Yuan, Ganesh K. Kumar Reactive oxygen species facilitate oxygen sensing 95

/ C. A. Nurse, J. Buttigieg, R. Thompson, M. Zhang, E. Cutz Oxygen sensing in neuroepithelial and adrenal chromaffin cells 106

/ C. Peers, P. Kang, J. P. Boyle, K. E. Porter, H. A. Pearson, I. F. Smith, P. J. Kemp Hypoxic regulation of Ca[superscript 2+] signalling in astrocytes and endothelial cells 119

/ Paul J. Kemp, Sandile E. J. Williams, Helen S. Mason, Phillippa Wootton, David E. Iles, Daniela Riccardi, Chris Peers Functional proteomics of BK potassium channels: defining the acute oxygen sensor 141

/ Stephen L. Archer, Evangelos D. Michelakis, Bernard Thebaud, Sebastien Bonnet, Rohit Moudgil, Xi-Chen Wu, E. Kenneth Weir A central role for oxygen-sensitive K[superscript +] channels and mitochondria in the specialized oxygen-sensing system 157

/ Gregory B. Waypa, Paul T. Schumacker Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction 176

/ Norbert Weissmann, Ralph T. Schermuly, Hossein A. Ghofrani, Jorg Hanze, Parag Goyal, Friedrich Grimminger, Werner Seeger Hypoxic pulmonary vasoconstriction-triggered by an increase in reactive oxygen species? 196

/ Alison M. Gurney, Shreena Joshi The role of twin pore domain and other K[superscript +] channels in hypoxic pulmonary vasoconstriction 218

/ A. Mark Evans, D. Grahame Hardie, Antony Galione, Chris Peers, Prem Kumar, Christopher N. Wyatt AMP-activated protein kinase couples mitochondrial inhibition by hypoxia to cell-specific Ca[superscript 2+] signalling mechanisms in oxygen-sensing cells 234

/ Silke Becker, Gregory A. Knock, Vladimir Snetkov, Jeremy P. T. Ward, Philip I. Aaronson Role of capacitative Ca[superscript 2+] entry but not Na[superscript 2+]/Ca[superscript 2+] exchange in hypoxic pulmonary vasoconstriction in rat intrapulmonary arteries 259.

Notes:

"Symposium on Signalling pathways in acute oxygen sensing, held at the Novartis Foundation, London, 25-27 January 2005" - contents.

Includes bibliographical references and indexes.

ISBN:

0470014571

OCLC:

63390461

Publisher Number:

9780470014578