Transplantation immunology : methods and protocols / edited by Philip Hornick, Marlene Rose.

Format:

Book

Contributor:

Hornick, Philip.

Rose, Marlene L.

Series:

Methods in molecular biology (Clifton, N.J.) ; v. 333.

Methods in molecular biology, 1064-3745 ; 333

Language:

English

Subjects (All):

Transplantation immunology.

Graft Rejection--diagnosis.

Graft Rejection--immunology.

Clinical Laboratory Techniques.

Organ Transplantation--adverse effects.

Transplantation, Homologous--immunology.

Medical Subjects:

Graft Rejection--diagnosis.

Graft Rejection--immunology.

Clinical Laboratory Techniques.

Organ Transplantation--adverse effects.

Transplantation, Homologous--immunology.

Physical Description:

x, 429 pages : illustrations ; 24 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2006]

Summary:

Technical innovations in the laboratory over the past ten years have greatly improved our understanding of the immunological mechanisms of transplanted organ rejection. In Transplantation Immunology: Methods and Protocols, leading experts in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.

State of the art and highly practical, Transplantation Immunology: Methods and Protocols illuminates for clinicians and scientists-both newcomers and experts-the new world of detecting and monitoring patients' immunological responses to solid organ transplantation.

Contents:

Current status of renal transplantation / Christopher J. Callaghan and J. Andrew Bradley

Current status of liver transplantation / Peter J. Friend and Charles J. Imber

Current status of clinical islet cell transplantation / Jonathan R.T. Lakey, Mohammadreza Mirbolooki, and A.M. James Shapiro

Current status of lung transplantation / Allan R. Glanville

Chronic rejection in the heart / Philip Hornick and Marlene Rose

Direct and indirect allorecognition / Philip Hornick

HLA typing and its influence on organ transplantation / Stephen Sheldon and Kay Poulton

Strategies for gene transfer to solid organs : viral vectors / Charlotte Lawson

Nonviral vectors / Louise Collins

Detection and clinical relevance of antibodies after transplantation / John D. Smith and Marlene Rose

Reprogramming the immune system using antibodies / Luis Graca and Hermann Waldmann

In vitro assays for immune monitoring in transplantation / Maria P. Hernandez-Fuentes and Alan Salama

Proteomics and laser microdissection / Emma McGregor and Ayesha De Souza

Real-time quantitative polymerase chain reaction in cardiac transplant research / Leanne E. Felkin, Anne B. Taegtmeyer, and Paul J.R. Barton

Organ preservation / Mark Hicks ... [et al.]

Pharmacological manipulation of the rejection response / Peter Mark Anthony Hopkins

Experimental models of graft arteriosclerosis / Bezhad Soleimani and Victor C. Shi.

Notes:

Includes bibliographical references and index.

ISBN:

1588295443

OCLC:

61860824