Small-animal SPECT imaging / Matthew A. Kupinski, Harrison H. Barrett (eds.).

Format:

Book

Conference/Event

Contributor:

Kupinski, Matthew A.

Barrett, Harrison H.

Conference Name:

Workshop on Small-Animal SPECT (2004 : Tucson, Ariz.)

Language:

English

Subjects (All):

Animal models in research--Congresses.

Animal models in research.

Imaging systems in medicine--Congresses.

Imaging systems in medicine.

Imaging systems in biology--Congresses.

Imaging systems in biology.

Tomography, Emission--Congresses.

Tomography, Emission.

Genre:

Conference papers and proceedings.

Physical Description:

xxii, 294 pages : illustrations ; 25 cm

Place of Publication:

New York : Springer, 2005.

Summary:

Small-Animal SPECT Imaging offers a comprehensive overview of the cutting edge imaging tool that can aid in drug development, drug research, molecular imaging, and imaging science. It represents contributions of the world's leading researchers in small-animal SPECT imaging, providing coverage from the basic physics of SPECT imaging to animal studies. Important integrated sections on animal handling, image quality assessment, and reconstruction algorithms are included, allowing its audience to design and run their own studies.

Small-Animal SPECT Imaging is aimed at researchers performing imaging to study the effects of drugs, molecular agents, and treatments, including molecular imaging scientists, imaging scientists; nuclear medicine researchers, and all those interested in the application of SPECT systems in the areas of cancer research, cardiovascular research, and gene therapy

Contents:

Chapter 1 Biomedical Significance of Small-Animal Imaging / James M. Woolfenden, Zhonglin Liu 1

2 Selection of radiopharmaceuticals 2

3 Applications: Ischemic heart disease 4

4 Applications in oncology 5

Chapter 2 Detectors for Small-Animal SPECT I / Harrison H. Barrett, William C. J. Hunter 9

2 Image formation 10

3 Detector requirements 16

4 Approaches to gamma-ray detection 26

5 Semiconductor detectors 31

6 Scintillation detectors 37

7 Summary and future directions 42

Chapter 3 Detectors for Small-Animal SPECT II / Harrison H. Barrett 49

2 Role of statistics 50

3 Poisson statistics 53

4 Random amplification 60

5 Approaches to estimation 63

6 Application to scintillation cameras 66

7 Semiconductor detectors 81

Chapter 4 The Animal in Animal Imaging / Gail Stevenson 87

2 Health surveillance programs 88

3 Species specifics 88

4 On arrival 90

5 Anesthetics 91

6 Animal monitoring 94

7 Regulations 98

Chapter 5 Objective Assessment of Image Quality / Matthew A. Kupinski, Eric Clarkson 101

2 Image quality 103

3 The Hotelling observer 110

4 The channelized Hotelling observer 110

Chapter 6 SPECT Imager Design and Data-Acquisition Systems / Lars R. Furenlid, Yi-Chun Chen, Hyunki Kim 115

2 Gamma-ray optics 115

3 SPECT imager design 124

4 Electrical signals from gamma-ray detectors 133

5 Data acquisition architectures 134

Chapter 7 Computational Algorithms in Small-Animal Imaging / Donald W. Wilson 139

2 Reconstruction 139

3 System modeling 150

Chapter 8 Reconstruction Algorithm with Resolution Deconvolution in a Small-Animal PET Imager / Edward N. Tsyganov, Alexander I. Zinchenko et al. 163

1 Experimental setup 163

2 List-mode EM algorithm with convolution model 165

3 Results for simple phantoms 166

4 Double Compton scattering model 170

5 Application of EM algorithm for image deblurring 173

Chapter 9 Estimates of Axial and Transaxial Resolution for One-, Two-, and Three-Camera Helical Pinhole SPECT / Scott D. Metzler, Ronald J. Jaszczak 177

2 Experimental acquisition 177

3 Estimating experimental resolution 178

4 Fitting a Gaussian-convolved impulse function 179

5 Results 180

Chapter 10 Pinhole Aperture Design for Small-Animal Imaging / Chih-Min Hu, Jyh-Cheng Chen, Ren-Shyan Liu 183

2 Theory 183

3 Materials and Methods 184

4 Results 185

Chapter 11 Comparison of CsI(Ti) and Scintillating Plastic in a Multi-Pinhole/CCD-Based Gamma Camera for Small-Animal Low-Energy SPECT / Edmond Richer, Matthew A. Lewis, Billy Smith, Xiufeng Li et al. 189

2 CCD-based gamma camera 189

3 Plastic scintillators 192

4 Conclusions and future work 194

Chapter 12 Calibration of Scintillation Cameras and Pinhole SPECT Imaging Systems / Yi-Chun Chen, Lars R. Furenlid, Donald W. Wilson, Harrison H. Barrett 195

3 Experiment construction and data processing 196

4 Interpolation of the H matrix 198

Chapter 13 Imaging Dopamine Transporters in a Mouse Brain with Single-Pinhole SPECT / Jan Booij, Gerda Andringa, Kora de Bruin, Jan Habraken, Benjamin Drukarch 203

2 Methods and materials 204

3 Results 206

Chapter 14 A Micro-SPECT/CT System for Imaging of AA-Amyloidosis in Mice / Jens Gregor, Shaun Gleason, Stephen Kennel, et al. 209

2 MicroCT instrumentation and reconstruction 210

3 MicroSPECT instrumentation and reconstruction 210

4 Preliminary experimental results 211

Chapter 15 Feasibility of Micro-SPECT/CT Imaging of Atherosclerotic Plaques in a Transgenic Mouse Model / Benjamin M. W. Tsui, Yuchuan Wang, Yujin Qi, Stacia Sawyer, et al. 215

2 Methods 217

3 Results 219

Chapter 16 Effect of Respiratory Motion on Plaque Imaging in the Mouse Using Tc-99m Labeled Annexin-V / William P. Segars, Yuchuan Wang, Benjamin M. W. Tsui 225

2 Methods 226

3 Results 228

Chapter 17 Calibration and Performance of the Fully Engineered YAP-(S)PET Scanner for Small Rodents / Alberto Del Guerra, Nicola Belcari, Deborah Herbert et al. 233

2 YAP-(S)PET scanner design 233

3 YAP-(S)PET scanner performance 234

Chapter 18 A Small-Animal SPECT Imaging System Utilizing Position Tracking of Unanesthetized Mice / Andrew G. Weisenberger, Brian Kross, Stan Majewski, Vladimir Popov, et al. 239

2 Imaging methodology 239

3 Apparatus description 240

Chapter 19 A Multidetector High-Resolution SPECT/CT Scanner with Continuous Scanning Capability / Tobias Funk, Minshan Sun, Andrew B. Hwang, James Carver, et al. 245

2 Design of the SPECT/CT system 246

Chapter 20 High-Resolution Multi-Pinhole Imaging Using Silicon Detectors / Todd E. Peterson, Donald W. Wilson, Harrison H. Barrett 251

2 Impact of detector resolution on pinhole imaging 252

3 Silicon imager prototype 254

4 The synthetic collimator 255

Chapter 21 Development and Characterization of a High-Resolution MicroSPECT System / Yujin Qi, Benjamin M.W. Tsui, Yuchuan Wang, Bryan Yoder 259

2 Imaging system and method 259

3 Results 262

Chapter 22 High-Resolution Radionuclide Imaging Using Focusing Gamma-Ray Optics / Michael Pivovaroff, William Barber, Tobias Funk 267

2 Radionuclide imaging: Traditional approach 267

3 Radionuclide imaging: Focusing [gamma]-ray optics 268

Chapter 23 SPECT/Micro-CT Imaging of Bronchial Angiogenesis in a Rat / Anne V. Clough, Christian Wietholt, Robert C. Molthen 273

2 Methods 274

3 Results 274

Chapter 24 Projection and Pinhole-Based Data Acquisition for Small-Animal SPECT Using Storage Phosphor Technology / Matthew A. Lewis, Gary Arbique, Edmond Richer, Nikolai Slavine 279

3 Prototype 281

4 Results 282

Chapter 25 Cardiac Pinhole-Gated SPECT in Small Animals / Tony Lahoutte, Chris Vanhove, Philippe R. Franken 287

2 Animal preparation and handling 287

3 Radiopharmaceuticals 288

4 Pinhole-gated SPECT imaging 288

5 Data reconstruction 288

6 Data analysis 289

7 Reproductibility study 289

8 Monitoring the negative effect of halothane gas 289

9 Monitoring the positive inotropic effect of dobutamine 290.

Notes:

Includes bibliographical references and index.

ISBN:

038725143X

OCLC:

61029927

Publisher Number:

9780387251431