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Quasispecies : concept and implications for virology / E. Domingo (ed.).
Holman Biotech Commons QR1 .E6 v.299 2006
Available
Holman Biotech Commons QR1 .E6 v.253 (2001)-v.363,v.367-v.371
Available
Veterinary: Atwood Library (Campus) QR181 O75 2000
Available
LIBRA v.40 (1967)-v.113 (1984), v.115 (1985)-v.203 (1995), v.205 (1996)-v.252 (2000)
Available from offsite location
Levy Dental Medicine Library - Stacks QR1 .E6 215,271
Mixed Availability
Veterinary: du Pont Library (New Bolton) QR1 .E6 280
Mixed Availability
Veterinary: Atwood Library (Campus) QR1 .E6 271
Mixed Availability
- Format:
- Book
- Series:
- Current topics in microbiology and immunology 0070-217X ; 299.
- Current topics in microbiology and immunology, 0070-217X ; 299
- Language:
- English
- Subjects (All):
- RNA viruses.
- Virology.
- Virus diseases--Immunological aspects.
- Virus diseases.
- Species.
- RNA Viruses--genetics.
- Mutagenesis.
- Evolution, Molecular.
- Population Dynamics.
- Medical Subjects:
- RNA Viruses--genetics.
- Mutagenesis.
- Evolution, Molecular.
- Population Dynamics.
- Physical Description:
- x, 407 pages : illustrations (some color) ; 24 cm.
- Other Title:
- Quasispecies : concepts and implications for virology
- Place of Publication:
- Berlin ; New York : Springer, [2006]
- Summary:
- Viruses exploit genetic variation in their constant interaction with host cells. Remarkable among the adaptive strategies, RNA viruses, and probably some DNA viruses, generate complex mutant swarms termed viral quasispecies. The central topics of this volume are the origins of the quasispecies concept and the implications of quasispecies dynamics for viral populations. Some chapters emphasize general concepts (quasispecies, sequence space, fitness, error catastrophe, lethal defection, adaptive responses, population bottlenecks, etc.) and others the population dynamics of specific viruses such as picornaviruses, pestiviruses, arenaviruses, arboviruses, human immunodeficiency virus, plant viruses and some DNA viruses that display features of RNA genetics, as well as the implications of quasispecies dynamics in vivo. The volume provides an in-depth review of quasispecies and discusses possible avenues for further research.
- Contents:
- What Is a Quasispecies? / C. K. Biebricher, M. Eigen 1
- Quasispecies in Time-Dependent Environments / C. O. Wilke, R. Forster, I. S. Novella 33
- Viruses as Quasispecies: Biological Implications / E. Domingo, V. Martin, C. Perales, A. Grande-Perez, J. Garcia-Arriaza, A. Arias 51
- Virus Fitness: Concept, Quantification, and Application to HIV Population Dynamics / M. E. Quinones-Mateu, E. J. Arts 83
- Population Bottlenecks in Quasispecies Dynamics / C. Escarmis, E. Lazaro, S. C. Manrubia 141
- Evolutionary Dynamics of HIV-1 and the Control of AIDS / J. I. Mullins, M. A. Jensen 171
- Evolution of Virulence in Picornaviruses / S. Tracy, N. M. Chapman, K. M. Drescher, K. Kono, W. Tapprich 193
- Molecular Mechanisms of Poliovirus Variation and Evolution / V. I. Agol 211
- Hepatitis C Virus Population Dynamics During Infection / J.-M. Pawlotsky 261
- Evolutionary Influences in Arboviral Disease / S. C. Weaver 285
- Arenavirus Diversity and Evolution:Quasispecies In Vivo / N. Sevilla, J. C. de la Torre 315
- Mutant Clouds and Occupation of Sequence Space in Plant RNA Viruses / M. J. Roossinck, W. L. Schneider 337
- Parvovirus Variation for Disease: A Difference with RNA Viruses? / A. Lopez-Bueno, L. P. Villarreal, J. M. Almendral 349
- Transitions in Understanding of RNA Viruses: A Historical Perspective / J. J. Holland 371.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 3540263950
- OCLC:
- 61703250
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