Computational systems biology / edited by Andres Kriete, Roland Eils.

Format:

Book

Contributor:

Kriete, Andres.

Eils, Roland.

Language:

English

Subjects (All):

Biological systems--Computer simulation.

Biological systems.

Computational Biology.

Systems Biology.

Medical Subjects:

Computational Biology.

Systems Biology.

Physical Description:

x, 409 pages, 8 unnumbered pages of plates : illustrations (some color) ; 24 cm

Place of Publication:

Burlington, MA ; San Diego : Elsevier Academic Press, [2006]

Summary:

Systems Biology is concerned with the quantitative study of complex biosystems at the molecular, cellular, tissue, and systems scales. Its focus is on the function of the system as a whole, rather than on individual parts. This exciting new arena applies mathematical modeling and engineering methods to the study of biological systems. This book is the first of its kind to focus on the newly emerging field of systems biology with an emphasis on computational approaches. The work covers new concepts, methods for information storage, mining and knowledge extraction, reverse engineering of gene and metabolic networks, as well as modelling and simulation of multi-cellular systems. Central themes include strategies for predicting biological properties and methods for elucidating structure-function relationships.

Contents:

Introducing computational systems biology / Andres Kriete and Roland Eils

Databases for systems biology / Jürgen Eils ... [et al.]

Natural language processing and ontology-enhanced biomedical literature mining for systems biology / Xiaohua Hu

Integrated imaging informatics / Barham Parvin ... [et al.]

Simpathica: a computational systems biology tool within the valis bioinformatics environment / Bud Mishra ... [et al.]

Standards, platforms, and applications / Herbert M. Sauro

Introduction to computational models of biochemical reaction networks / Frank J. Bruggeman ... [et al.]

Biological foundations of signal transduction and the systems biology perspective / Ursula Klingmüller

Reconstruction of metabolic network from genome information and its structural and functional analysis / Hong-Wu Ma and An-Ping Zeng

Integrated regulatory and metabolic models / Markus W. Covert

A discrete approach to network modeling / Reinhard Laubenbacher and Pedro Mendes

Gene networks: estimation, modeling and simulation / Seiya Imoto, Hiroshi Matsuno, and Satoru Miyano

Computational models for circadian rhythms: deterministic versus stochastic approaches / Jean-Christophe Leloup, Didier Gonze, and Albert Goldbeter

Multistability and multicellularity: cell fates as high-dimensional attractors of gene regulatory networks / Sui Huang

Spatio-temporal systems biology / Avijit Ghosh ... [et al.]

Cytomics

from cell states to predictive medicine / Günter Valet ... [et al.]

The IUPS Physiome Project: progress and plans / Peter Hunter ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

012088786X

OCLC:

65204762

Publisher Number:

9780120887866