The dog and its genome / edited by Elaine A. Ostrander, Urs Giger, Kerstin Lindblad-Toh.

Format:

Book

Contributor:

Ostrander, Elaine A.

Giger, Urs.

Lindblad-Toh, Kerstin.

Series:

Cold Spring Harbor monograph series ; 44.

Cold Spring Harbor monograph series ; 44

Language:

English

Subjects (All):

Dogs--Genetics.

Dogs.

Dogs--Breeding.

Dogs--genetics.

Animals, Domestic.

Breeding.

Medical Subjects:

Dogs--genetics.

Animals, Domestic.

Breeding.

Physical Description:

xix, 584 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, [2006]

Summary:

Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty-six chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as cancer, blindness, deafness, neurological diseases, and epilepsy.

Contents:

Breed Clubs and Canine History

1 Canine History and Breed Clubs / J.A. Moody, L.A. Clark, K.E. Murphy 1

2 The Kennel Club and the Early History of Dog Shows and Breed Clubs / J. Sampson, M.M. Binns 19

3 American Breed Clubs and Health Initiatives / J.S. Bell 31

Breed Characteristics and Morphology

4 Morphological Variation in the Dog / A. Young, D. Bannasch 47

5 Genetic Analysis of the Canid Skeleton: Morphological Loci in the Portuguese Water Dog Population / K.G. Lark, K. Chase, D.R. Carrier, F.R. Adler 67

6 Morphology and Behavior: Are They Coupled at the Genome Level? / L.N. Trut, A.V. Kharlamova, A.V. Kukekova, G.M. Acland, D.R. Carrier, K. Chase, K.G. Lark 81

Canine Origins

7 From Wild Wolf to Domestic Dog / J.A. Leonard, C. Vila, R.K. Wayne 95

8 mtDNA Studies of the Origin of Dogs / P. Savolainen 119

9 Understanding Genetic Relationships among Purebred Dogs: The PhyDo Project / H.G. Parker, N.B. Sutter, E.A. Ostrander 141

Genomics and Genome Organization

10 Karyotype and Chromosomal Organization / M. Breen, R. Thomas 159

11 The Dog Genome: Sequence, Evolution, and Haplotype Structure / C.M. Wade, E.K. Karlsson, T.S. Mikkelsen, M.C. Zody, K. Lindblad-Toh 179

12 SINEs of Canine Genomic Diversity / E.F. Kirkness 209

13 The Dog Olfactory and Vomeronasal Receptor Repertoires / P. Quignon, S. Tacher, M. Rimbault, F. Galibert 221

14 The Canine Major Histocompatibility Complex / J.L. Wagner, R.F. Storb 233

Genetic Disease and Gene Mapping

15 Breed-specific Hereditary Diseases and Genetic Screening / U. Giger, D.R. Sargan, E.A. McNeil 249

16 Models, Mutants, and Man: Searching for Unique Phenotypes and Genes in the Dog Model of Inherited Retinal Degeneration / G.D. Aguirre, G.M. Acland 291

17 Copper Toxicosis in Bedlington Terriers / B. van de Sluis, C. Wijmenga, B.A. van Oost 327

18 Cystinuria / P.S. Henthorn, U. Giger 349

19 Molecular Genetics of Dilated Cardiomyopathy / P. Stabej, K.M. Meurs, B.A. van Oost 365

20 Sex Chromosomes, Sexual Development, and Sex Reversal in the Dog / V.N. Meyers-Wallen 383

21 QTL Mapping Using Crossbreed Pedigrees: Strategies for Canine Hip Dysplasia / R.G. Mateescu, N.L. Dykes, R.J. Todhunter, G.M. Acland, N.I. Burton-Wurster, G. Lust, Z. Zhang, R.L. Quaas, K. Tsai, K. Murphy 407

Cancer

22 Breed-specific Canine Lymphoproliferative Diseases / J.F. Modiano, M. Breen, A.C. Avery, C.A. London 439

23 Cancer Biology in Dogs / C. Khanna, M.C. Paoloni 451

Gene Therapy

24 Gene Therapy for Metabolic Inherited Diseases in Dogs / N.M. Ellinwood, M.L. Casal, M.E. Haskins 473

Behavior

25 Behavioral Genetics of Dog Cognition: Human-like Social Skills in Dogs Are Heritable and Derived / B. Hare, M. Tomasello 497

26 The Genetics of Domesticated Behavior in Canids: What Can Dogs and Silver Foxes Tell Us about Each Other? / A.V. Kukekova, G.M. Acland, I.N. Oskina, A.V. Kharlamova, L.N. Trut, K. Chase, K.G. Lark, H.N. Erb, G.D. Aguirre 515

Appendix Illustrations of AKC Recognized Dog Breeds 539.

Notes:

Includes bibliographical references and index.

ISBN:

0879697423

OCLC:

60931359