The neurobiology of pain : (molecular and cellular neurobiology) / edited by Stephen P. Hunt, Martin Koltzenburg.

Format:

Book

Contributor:

Hunt, Stephen P.

Koltzenburg, Martin, 1962-

Series:

Molecular and cellular neurobiology series

Language:

English

Subjects (All):

Pain.

Pain--Physiological aspects.

Neurobiology.

Nociceptors--physiology.

Medical Subjects:

Pain.

Neurobiology.

Nociceptors--physiology.

Physical Description:

ix, 403 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 25 cm.

Place of Publication:

Oxford ; New York : Oxford University Press, 2005.

Summary:

The last decade has seen major advances in the neurobiology of pain, primarily resulting from a deeper understanding of the way in which pain signals are coded and processed in the nervous system. This volume is the first book for many years to present an integrated overview of the current state of research into the neurobiology of chronic and acute pain.

While recent molecular aspects of nociception are covered in some detail, the book also emphasizes the importance of viewing the pain experience as the co-ordinated response of many different areas of the nervous system. The molecular advances are set in the context of the neurobiological system of pain processing. The appropriate behavioural response to injury can therefore be thought of as the result of the integration of information processed within areas of the brain concerned with cognition, affect, sensory discrimination, and movement.

Chapters cover recent advances in nociceptor transduction mechanisms, nociceptor plasticity, and the biochemical anatomy of pain pathways. Other contributions are concerned with the development of pain systems and with the central processing of nociceptive information studied with brain imaging techniques. Several chapters additionally cover the mechanisms of clinically important pain states such as neuropathic pain, cancer related pain, and migraine.

A new volume in the Molecular and Cellular Neurobiology series, The Neurobiology of Pain presents a state-of-the-art account of the neurobiological basis of pain, edited and written by the leading scientists in this field.

Contents:

1 Molecular biology of nociceptors / M.J. Caterina, M.S. Gold, R.A. Meyer 1

2 Nociceptor plasticity / S.B. McMahon, J.V. Priestley 35

3 Molecular architecture of the dorsal horn / A.J. Todd, A. Ribeiro-da-Silva 65

4 Cellular and molecular mechanisms of central sensitization / M.W. Salter, C.J. Woolf 95

5 Mechanisms of peripheral neuropathic pain / M. Koltzenburg 115

6 Targets in pain and analgesia / A.H. Dickenson, R. Suzuki 149

7 The ascending pain pathways / S.P. Hunt, H. Bester 165

8 Spinal delivery of drugs in pain control / T.L. Yaksh, P.W. Mantyh 185

9 The development of pain systems / M. Fitzgerald, A. MacDermott 207

10 Visceral and deep somatic pain / J.M.A. Laird, H.-G. Schaible 239

11 The organization of the midbrain periaqueductal grey and the integration of pain behaviours / T. Lovick, R. Bandler 267

12 Descending control of pain processing / G.F. Gebhart, H.K. Proudfit 289

13 Central imaging of pain / H. Flor, M.C. Bushnell 311

14 Headache / P.J. Goadsby, M.D. Ferrari 333

15 An integrative approach to the control of cancer pain / P.W. Mantyh, T.L. Yaksh 375.

Notes:

Includes bibliographical references and index.

ISBN:

0198515618

OCLC:

62563181