Sodium channels, pain, and analgesia / Kevin Coward, Mark D. Baker editors.

Format:

Book

Contributor:

Coward, Kevin, 1969-

Baker, Mark D., 1960-

Series:

PIR (Series)

Progress in inflammation research

Language:

English

Subjects (All):

Pain.

Sodium channels.

Analgesics.

Sodium Channels.

Medical Subjects:

Pain.

Sodium Channels.

Analgesics.

Physical Description:

ix, 199 pages : illustrations (partly color) ; 24 cm.

Place of Publication:

Basel ; Boston, MA : Birkhauser, 2005.

Summary:

Sodium channels confer excitability on neurons in nociceptive pathways and exhibit neuronal tissue specific and injury regulated expression. This volume provides recent insights into the control of expression, functioning and membrane trafficking of nervous system sodium channels and reviews why sodium channel sub-types are potentially important drug targets in the treatment of pain. The roles of sodium channels in dental and visceral pain are also addressed. The emerging role of sodium channel Na[subscript v] 1.3 in neuropathic states is another important theme. Authors from the pharmaceutical industry discuss pharmacological approaches to the drug targeting of sodium channels, and in particular Na[subscript v] 1.8, exclusively expressed in nociceptive neurons. The final chapter highlights the functional diversity of sodium channels in part provided by post-transcriptional processing and the insights into sodium channel function that are being provided by tissue specific and inducible gene knock-out technology.

Contents:

Voltage-gated sodium channels and pain associated with nerve injury and neuropathies / Joel A. Black, Bryan C. Hains, Sulayman D. Dib-Hajj, Stephen G. Waxman 1

Current approaches for the discovery of novel Na[subscript v] channel inhibitors for the treatment of brain disorders / Jeffrey J. Clare 23

Voltage-gated sodium channels and visceral pain / Jennifer M.A. Laird, Fernando Cervero 63

The functional interaction of accessory proteins and voltage-gated sodium channels / Kenji Okuse, Mark D. Baker 71

Sodium channels and nociceptive nerve endings / James A. Brock 85

Signalling cascades that modulate the activity of sodium channels in sensory neurons / Grant D. Nicol 107

Na[subscript v] 1.8 as a drug target for pain / Lodewijk V. Dekker, David Cronk 123

Role of voltage-gated sodium channels in oral and craniofacial pain / Michael S. Gold 145

Sodium channel gating and drug blockade / Andreas Scholz 165

Future directions in sodium channel research / John N. Wood 181.

Notes:

Includes bibliographical references and index.

ISBN:

3764370629

OCLC:

60375524

Publisher Number:

9783764370626