From melanocytes to melanoma : the progression to malignancy / edited by Vincent J. Hearing, Stanley P. L. Leong.

Format:

Book

Contributor:

Hearing, Vincent J.

Leong, Stanley P. L.

Language:

English

Subjects (All):

Melanoma.

Cell transformation.

Melanocytes.

Melanoma--physiopathology.

Cell Transformation, Neoplastic.

Melanocytes--physiology.

Melanoma--therapy.

Medical Subjects:

Melanoma--physiopathology.

Cell Transformation, Neoplastic.

Melanocytes--physiology.

Melanoma--therapy.

Physical Description:

xvii, 678 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 26 cm

Place of Publication:

Totowa, N.J. : Humana Press, [2006]

Summary:

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.

Contents:

The origin and development of neural crest-derived melanocytes / Debra L. Silver and William J. Pavan

MITF: a matter of life and death for the developing melanocytes / Heinz Arnheiter ... [et al.]

MITF: critical regulator of the melanocyte lineage / Erez Feige, Laura L. Poling, and David E. Fisher

Melanocytes and the transcription factor Sox10 / Micheal Wegner

Human cutaneous pigmentation: a collaborative act in the skin, directed by paracrine, autocrine, and endocrine factors and the environment / Zalfa A. Abdel-Malek and Ana Luisa Kadekaro

Melanocyte distribution and function in human skin: effects of ultraviolet radiation / Yuji Yamaguchi and Vincent J. Hearing

Altered signal transduction in melanoma / Pablo López Bergami, Anindita Bhoumik, and Ze'ev Ronai

BRN2 in melanocytic cell development, differentiation, and transformation / Anthony L. Cook ... [et al.]

The dynamic roles of cell-surface receptors in melanoma development / Dong Fang and Meenhard Herlyn

Familial melanoma genes, melanocyte immortalization, and melanoma initiation / Dorothy C. Bennett

Genetic progression from melanocyte to malignant melanoma / Boris C. Bastian

The multiple roles of the oncogenic protein SKI in human malignant melanoma / Dahu Chen ... [et al.]

RB/E2F regulation and dual activity in the melanocytic system / Ruth Halaban

Melanoma development and pigment cell transformation / Claudia Wellbrock

The biology and genetics of melanoma / Norman E. Sharpless and Lynda Chin

The biology of xeroderma pigmentosum: insights into the role of ultraviolet light in the development of melanoma / James E. Cleaver

Divergent pathways to cutaneous melanoma / David C. Whiteman and Adèle C. Green

Pigmentation, DNA repair, and candidate genes: the risk of cutaneous malignant melanoma in a mediterranean population / Maria Teresa Landi

Low-penetrance genotypes, pigmentation phenotypes, and melanoma etiology / Peter A. Kanetsky and Timothy R. Rebbeck

The biology of melanoma progression: from melanocyte to metastatic seeds / A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr.

Optical imaging analysis of atypical nevi and melanoma / Amanda Pfaff Smith and Dorothea Becker

Proteomics analysis of melanoma cell lines and cultured melanocytes / Katheryn A. Resing and Natalie G. Ahn

Paradigm of metastasis for malignant melanoma / Stanley P.L. Leong

Repair of UV-induced DNA damage and melanoma risk / Qingyi Wei

High-risk factors for melanoma metastasis / Neil A. Accortt and Seng-jaw Soong

Role of melanoma inhibitory activity in early development of malignant melanoma / Anja-Katrin Bosserhoff

Role and regulation of PAR-1 in melanoma progression / Carmen Tellez and Menashe Bar-Eli

Molecular mechanisms of melanoma metastasis / Mohammed Kashani-Sabet

Overview of tumor progression in melanoma / David E. Elder

The plasticity of melanoma cells and associated clinical implications / Mary J. C. Hendrix ... [et al.]

The clinical use of molecular markers as predictors of disease outcome and response to therapy in malignant melanoma / Steve R. Martinez, Hiroya Takeuchi, Dave S.B. Hoon

The role of DCT/TYRP2 in resistance of melanoma cells to drugs and radiation / Brian J. Pak and Yaacov Ben-David

How melanoma cells evade chemotherapy: role of transporter-dependent and -independent resistance mechanisms / Kevin G. Chen and Michael M. Gottesman

Apoptosis in melanoma: approaches to therapy / Heicke Röckmann and Dirk Schadendorf

Role of melanoma-associated antigens / Rishab K. Gupta, Ana M. McElrath-Garza, and Donald L. Morton

Host responses to melanoma: implications for immunotherapy / Julian A. Kim and Ernest Borden

Future perspectives / Vincent J. Hearing and Stanley P.L. Leong.

Notes:

Includes bibliographical references and index.

ISBN:

1588294595

OCLC:

59147730

Publisher Number:

9781588294593