CCN proteins : a new family of cell growth and differentiation regulators / editors, Bernard Perbal and Masaharu Takigawa.

Format:

Book

Contributor:

Perbal, Bernard V.

Takigawa, Masaharu.

Language:

English

Subjects (All):

Cell differentiation--Molecular aspects.

Cell differentiation.

Protein-protein interactions.

Growth factors.

Immediate-Early Proteins.

Intercellular Signaling Peptides and Proteins.

Cell Differentiation.

Cell Proliferation.

Medical Subjects:

Immediate-Early Proteins.

Intercellular Signaling Peptides and Proteins.

Cell Differentiation.

Cell Proliferation.

Physical Description:

xi, 311 pages : illustrations (some color) ; 24 cm

Place of Publication:

London : Imperial College Press ; Hackensack, NJ : Distributed by World Scientific Pub. Co., [2005]

Summary:

The CCN Proteins are thought to play key roles in the biology of normal cell, tissue, organ, and body, and altered expression of CCN proteins is associated with several pathologies, including fibrosis and cancer. Because of its importance, the CCN field is expanding at a fast pace. Research articles in this field have recently increased logarithmically, and a book that is up-to-date, comprehensive, authoritative and affords insights into the biological roles of CCN proteins, is timely.

CCN Protein: A New Family of Cell Growth and Differentiation Regulators presents the most recent progress in the field of CCN proteins, a new family of secretory signaling molecules that are involved in several fundamental biological progress. These proteins share a unique multimodular organization and present a partial identity with four families of regulatory proteins controling growth and development. The book covers the roles of CCN proteins in the control of cell proliferation and differentiation during normal development, wound repair, chondrogenesis and bone development, angiogenesis, tissue regeneration, fibrosis, renal diseases and cancer development.

Contents:

Chapter 1 The CCN Family of Proteins: An Overview / Bernard Perbal, Masaharu Takigawa 1

Chapter 2 Roles of CCN2/CTGF in the Control of Growth and Regeneration / Masaharu Takigawa, Takashi Nishida, Satoshi Kubota 19

Chapter 3 Integrin-Mediated CCN Functions / Lester F. Lau, Stephen C.-T. Lam 61

Chapter 4 Expression and Roles of CCN2 During Odontogenesis / Manabu Kanyama, Tsuyoshi Shimo, Changshan Wu, Hiroki Sugito, Masahiro Iwamoto, Maurizio Pacifici, Eiki Koyama 81

Chapter 5 CCN Genes and the Kidney / Bruce L. Riser, Sujatha Karoor, Darryl R. Peterson 95

Chapter 6 CCN Proteins in Liver Injury and Disease / Amy W. Rachfal, David R. Brigstock 117

Chapter 7 Genetic Analysis of CCN Gene Function in Mammalian Development / Lisa M. Dornbach, Karen M. Lyons 135

Chapter 8 CCN Family in Embryonic Development (Non-Mammalian Models) / Branko V. Latinkic 153

Chapter 9 CCN3 Expression and its Role During Development / Ken-ichi Katsube 167

Chapter 10 Regulation of CCN Proteins by Alterations of the Cytoskeleton / Brahim Chaqour, Margarete Goppelt-Struebe 177

Chapter 11 Pathogenesis of Systemic Sclerosis and CCN2 (Connective Tissue Growth Factor) / Kazuhiko Takehara 197

Chapter 12 Function and Regulation of CCN5 / Mark R. Gray, John J. Castellot Jr. 207

Chapter 13 CCN3: A Multifunctional Signaling Regulator / Nathalie Planque, Anne-Marie Bleau, Bernard Perbal 239

Chapter 14 CCN Proteins and Connexins: Interactions and Growth Control / Christine Fu, Alexandra Gellhaus, Elke Winterhager, Christian C. Naus 259

Chapter 15 The Role of CCN1 in Tumorigenesis and Cancer Progression / James O'Kelly, H. Phillip Koeffler 273

Chapter 16 CCN4 and CCN6 Variants in Wnt-Inducible Signaling Pathway / Shinji Tanaka 293.

Notes:

Includes bibliographical references and index.

ISBN:

186094552X

OCLC:

61906540

Publisher Number:

9781860945526