Cytokines and the CNS / edited by Richard M. Ransohoff, Etty N. Benveniste.

Format:

Book

Contributor:

Ransohoff, Richard M.

Benveniste, Etty N.

Language:

English

Subjects (All):

Neuroimmunology.

Cytokines.

Cytokines--immunology.

Central Nervous System--cytology.

Central Nervous System Diseases--immunology.

Receptors, Cytokine--physiology.

Medical Subjects:

Cytokines--immunology.

Central Nervous System--cytology.

Central Nervous System Diseases--immunology.

Receptors, Cytokine--physiology.

Physical Description:

361 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 25 cm

Edition:

Second edition.

Place of Publication:

Boca Raton, FL : CRC Press/Taylor and Francis, 2006.

Summary:

As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines and their relationship with the central nervous system.

Cytokines and the CNS, Second Edition, designed for both clinicians and researchers, offers a fresh perspective and deepened insight into how cytokine action impacts the physiology and pathology of the nervous system. The similarity between factors involved in inflammation or immunity and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist's cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated on by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function.

Contents:

Chapter 1 The CNS: Cells, Tissues, and Reactions to Insult / Sunhee C. Lee, Melissa A. Cosenza, Qiusheng Si, Mark Rivieccio, Celia F. Brosnan 1

Chapter 2 Cytokines: Wherefrom and Whereto / Jan Vilcek 23

Chapter 3 Cytokine Receptors / Heidi Schooltink, Stefan Rose-John 39

Chapter 4 Cytokines and Signaling / Michael David 53

Chapter 5 Inflammatory Complexities in the CNS: New Insights into the Effects of Intracellular Redox State and Viral Infection in Modulating the Biology of Oligodendrocytes and Their Precursor Cells / Mark Noble, Margot Mayer-Proschel, David Mock, Chris Proschel 67

Chapter 6 Cytokines and Development of the Nervous System / Limin Gao, Robert H. Miller 93

Chapter 7 Cytokines in CNS Inflammation / Trevor Owens, Rachel D. Wheeler, Simone P. Zehntner 113

Chapter 8 Cytokines and Immune Regulation in the Nervous System / Wendy Smith Begolka, Eileen J. McMahon, Stephen D. Miller 137

Chapter 9 Cytokines and Neurodegeneration / Greer M. Murphy, Jr., Parvathy Saravanapavan 163

Chapter 10 Cytokine Expression and Signaling in Brain Tumors / Nandini Dey, Donald L. Durden, Erwin G. Van Meir 193

Chapter 11 Cytokines and Defense and Pathology of the CNS / Valery Combes, Georges E. Grau 243

Chapter 12 Cytokines and Multiple Sclerosis / P. Rieckmann 269

Chapter 13 Cytokines in Brain Trauma and Spinal Cord Injury / Roberta Brambilla, Valerie Bracchi-Ricard, John R. Bethea 299

Chapter 14 Cytokine-Based Therapeutics for Intrinsic CNS Disease Processes / Heinz Wiendl, Reinhard Hohlfeld 327.

Notes:

Includes bibliographical references and index.

ISBN:

0849316227

OCLC:

60419407

Publisher Number:

9780849316227