Phase II conjugation enzymes and transport systems / edited by Helmut Sies, Lester Packer.

Format:

Book

Contributor:

Sies, H. (Helmut), 1942-

Packer, Lester.

Series:

Methods in enzymology ; v. 400.

Methods in enzymology ; v. 400

Language:

English

Subjects (All):

Enzymes.

Biological transport.

Physical Description:

xxxix, 695 pages, 30 unnumbered pages : illustrations (some color) ; 24 cm.

Place of Publication:

Amsterdam ; Boston : Elsevier Academic Press, [2005]

Contents:

1 UDP-Glucuronosyltransferases: Gene Structures of UGT1 and UGT2 Families / Ida S. Owens, Nikhil K. Basu, Rajat Banerjee 1

2 Identification and Characterization of Functional Hepatocyte Nuclear Factor 1-Binding Sites in UDP-Glucuronosyltransferase Genes / Dione A. Gardner-Stephen, Philip A. Gregory, Peter I. Mackenzie 22

3 Substrate Specificity of Human Hepatic UDP-Glucuronosyltransferaes / Brian Burchell, David J. Lockley, Adam Staines, Yoshihiro Uesawa, Michael W. H. Coughtrie 46

4 UDP-Glucuronosyltransferase 1A6: Structural, Functional, and Regulatory Aspects / Karl Walter Bock, Christoph Kohle 57

5 The Role of Ah Receptor in Induction of Human UDP-Glucuronosyltransferase 1A1 / Mei-Fei Yueh, Jessica A. Bonzo, Robert H. Tukey 75

6 Regulation of the Human UGT1A1 Gene by Nuclear Receptors Constitutive Active/Androstane Receptor, Pregnane X Receptor, and Glucocorticoid Receptor / Junko Sugatani, Tatsuya Sueyoshi, Masahiko Negishi, Masao Miwa 92

7 Isoform-Selective Probe Substrates for In Vitro Studies of Human UDP-Glucuronosyltransferases / Michael H. Court 104

8 Structure of UDP-Glucuronosyltransferases in Membranes / Anna Radominska-Pandya, Mohamed Ouzzine, Sylvie Fournel-Gigleux, Jacques Magdalou 116

9 Human SULT1A Genes: Cloing and Activity Assays of the SULT1A Promoters / Nadine Hempel, Masahiko Negishi, Michael E. McManus 147

10 Vitamin D Receptor Regulation of the Steroid/Bile Acid Sulfotransferase SULT2A1 / Bandana Chatterjee, Ibtissam Echchgadda, Chung Seog Song 165

11 Screening and Characterizing Human NAT2 Variants / Mihaela R. Savulescu, Adeel Mushtaq, P. David Josephy 192

12 Inactivation of Human Arylamine N-Acetyltransferase 1 by Hydrogen Peroxide and Peroxynitrite / Jean-Marie Dupret, Julien Dairou, Noureddine Atmane, Fernando Rodrigues-Lima 215

13 Sulfotransferases and Acetyltransferases in Mutagenicity Testing: Technical Aspects / Hansruedi Glatt, Walter Meinl 230

14 A Comparative Molecular Field Analysis-Based Approach to Prediction of Sulfotransferase Catalytic Specificity / Vyas Sharma, Michael W. Duffel 249

15 Glucuronidase Deconjugation in Inflammation / Kayoko Shimoi, Tsutomu Nakayama 263

16 Three-Dimensional Structures of Sulfatases / Debashis Ghosh 273

17 Estrogen Sulfatase / Masao Iwamori 293

18 Analysis for Localization of Steroid Sulfatase in Human Tissues / Takashi Suzuki, Yasuhiro Miki, Tsuyoshi Fukuda, Taisuke Nakata, Takuya Moriya, Hironobu Sasano 303

19 Metabolism of Phytoestrogen Conjugates / Tracy L. D'Alessandro, Brenda J. Boersma-Maland, T. Greg Peterson, Jeff Sfakianos, Jeevan K. Prasain, Rakesh P. Patel, Victor M. Darley-Usmar, Nigel P. Botting, Stephen Barnes 316

20 Sulfation and Glucuronidation of Phenols: Implications in Coenzyme Q Metabolism / Nandita Shangari, Tom S. Chan, Peter J. O'Brien 342

21 Synthesis of Bile Acid Coenzyme A Thioesters in the Amino Acid Conjugation of Bile Acids / Erin M. Shonsey, James Wheeler, Michelle Johnson, Donging He, Charles N. Falany, Josie Falany, Stephen Barnes 360

22 Bile Acid Coenzyme A: Amino Acid N-Acyltransferase in the Amino Acid Conjugation of Bile Acids / Erin M. Shonsey, Mindan Sfakianos, Michelle Johnson, Donging He, Charles N. Falany, Josie Falany, David J. Merkler, Stephen Barnes 374

23 Multidrug Resistance Protein 1-Mediated Export of Glutathione and Glutathione Disulphide from Brain Astrocytes / Johannes Hirrlinger, Ralf Dringen 395

24 The Genetics of ATP-Binding Cassette Transporters / Michael Dean 409

25 Functional Analysis of Detergent-solubilized and Membrane-Reconstituted ATP-Binding Cassette Transporters / Bert Poolman, Mark K. Doeven, Eric R. Geertsma, Esther Biemans-Oldehinkel, Wil N. Konings, Douglas C. Rees 429

26 Yeast ATP-Binding Cassette Transporters: Cellular Cleaning Pumps / Robert Ernst, Robin Klemm, Lutz Schmitt, Karl Kuchler 460

27 High-Speed Screening of Human ATP-Binding Cassette Transporter Function and Genetic Polymorphisms: New Strategies in Pharmacogenomics / Toshihisa Ishikawa, Aki Sakurai, Yoichi Kanamori, Makoto Nagakura, Hiroyuki Hirano, Yutaka Takarada, Kazunari Yamada, Kazuhisa Fukushima, Masato Kitajima 485

28 Coordinate Transcriptional Regulation of Transport and Metabolism / Jyrki J. Eloranta, Peter J. Meier, Gerd A. Kullak-Ublick 511

29 Uptake and Efflux Transporters for Conjugates in Human Hepatocytes / Dietrich Keppler 531

30 Biliary Transport Systems: Short-Term Regulation / Ralf Kubitz, Angelika Helmer, Dieter Haussinger 542

31 Inborn Errors of Biliary Canalicular Transport Systems / Ralf Kubitz, Verena Keitel, Dieter Haussinger 558

32 Epoxide Hydrolases: Structure, Function, Mechanism, and Assay / Michael Arand, Annette Cronin, Magdalena Adamska, Franz Oesch 569

33 Pregnane X Receptor-Mediated Transcription / Thomas K. H. Chang, David J. Waxman 588

34 Animal Models of Xenobiotic Receptors in Drug Metabolism and Diseases / Haibiao Gong, Michael W. Sinz, Yan Feng, Taosheng Chen, Raman Venkataramanan, Wen Xie 598

35 Cancer and Molecular Biomarkers of Phase 2 / Kim Dalhoff, Kaspar Buus Jensen, Henrik Enghusen Poulsen 618.

Notes:

Includes bibliographical references and index.

ISBN:

0121828050

OCLC:

62458021