Integrated strategies for drug discovery using mass spectrometry / [edited by] Mike S. Lee.

Format:

Book

Contributor:

Lee, Mike S., 1960-

Language:

English

Subjects (All):

Mass spectrometry.

Drugs--Analysis.

Drugs.

High throughput screening (Drug development).

Drug Design.

Pharmaceutical Preparations--analysis.

Chromatography, Liquid--methods.

Pharmacokinetics.

Mass Spectrometry--methods.

Medical Subjects:

Drug Design.

Pharmaceutical Preparations--analysis.

Chromatography, Liquid--methods.

Pharmacokinetics.

Mass Spectrometry--methods.

Physical Description:

xvii, 550 pages : illustrations ; 25 cm

Place of Publication:

Hoboken, N.J. : Wiley-Interscience, [2005]

Summary:

* Shares historical background information on various techniques to aid in the understanding of how and why new methods are now being employed to analyze samples

Contents:

Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic and Neil L. Kelleher

Mass-spectrometry-based drug screening assays for early phases in drug discovery / Marshall M. Siegel

ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery ... [et al.]

Mass spectrometry-based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads ... [et al.]

Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor and Elaine Holmes

The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert ... [et al.]

Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng and Jill Hochlowski

A combinatorial process for drug discovery / David S. Wagner ... [et al.]

Application of technological advances in biotransformation studies / Carmen L. Fernández-Metzler, Raju Subramanian and Richard C. King

Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang ... [et al.]

Advances in high throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann, Michael J. Berna and Anthony T. Murphy

New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher

An integrated LC-MS strategy for preclinical candidate optimization / Jonathan L. Josephs and Mark Sanders

New approaches for method development and purification in lead optimization / Yining Zhao and David J. Semin

High throughput metabolic and physicochemical property analysis: strategies and tactics for impact on drug discovery success / Edward H. Kerns and Li Di

Organ perfusion and mass spectrometry / C. Gerald Curtis ... [et al.]

Sample preparation for drug discovery bioanalysis / David A. Wells

Automation / John D. Laycock and Thomas Hartmann.

Notes:

Includes bibliographical references and index.

ISBN:

047146127X

OCLC:

57579301

Publisher Number:

9780471461272