Biomarkers in breast cancer : molecular diagnostics for predicting and monitoring therapeutic effect / edited by Giampietro Gasparini and Daniel F. Hayes.

Format:

Book

Contributor:

Gasparini, Giampietro.

Hayes, Daniel, 1951-

Series:

Cancer drug discovery and development

Language:

English

Subjects (All):

Breast--Cancer--Molecular diagnosis.

Breast.

Breast--Cancer--Prognosis.

Tumor markers.

Breast Neoplasms--diagnosis.

Biomarkers, Tumor.

Medical Subjects:

Breast Neoplasms--diagnosis.

Biomarkers, Tumor.

Physical Description:

xi, 341 pages : illustrations ; 24 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2006]

Summary:

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Contents:

Guidelines for the design of clinical studies for the development and validation of therapeutically relevant biomarkers and biomarker-based classification systems / Richard M. Simon

Analytical aspects of biomarker immunoassays in cancer research / Fred C.G.J. Sweep, Chris M.G. Thomas and Manfred Schmitt

Tissue microarrays: state-of-the-art, pitfalls, and promises / Chungyeul Kim and Soonmyung Paik

Gene expression profiling with DNA microarrays: revolutionary tools to help diagnosis, prognosis, treatment guidance, and drug discovery / Michele De Bortoli and Nicoletta Biglia

Assays for gene amplification: state-of-the-art, pitfalls, and promises / Chungyeul Kim, Yongkuk Song, and Soonmyung Paik

Cell kinetics / Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori

Urokinase-type plasminogen activator and PAI-1: validated prognostic factors for breast cancer / Michael J. Duffy

Predictive value of c-erb-B2 for endocrine therapy and chemotherapy in breast cancer / Vered Stearns

erb-B2 as a therapeutic target / Robert Mass

The epidermal growth factor receptor pathway as a selective molecular-targeted treatment in human breast cancer / Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora

p53 as a prognostic and predictive indicator / Daniela Kandioler and Raimund Jakesz

Occult metastatic cells in breast cancer patients: state-of-the-art, pitfalls, and promises / Stephan Braun, Julia Seeber, and Christian Marth

Circulating HER2/neu: clinical utility / Allan Lipton ... [et al.]

Circulating vascular endothelial growth factor: methods, prognostic significance, and potential application for antiangiogenic therapy / Roberta Sarmiento ... [et al.]

Detection of early tumor dissemination in patients with breast cancer / Debra Hawes and Richard J. Cote

New technologies/new markers/new challenges / Daniel F. Hayes and Giampietro Gasparini.

Notes:

Includes bibliographical references and index.

ISBN:

1588292274

OCLC:

57506505