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Molecular neurosurgery with targeted toxins / edited by Ronald G. Wiley and Douglas A. Lappi.
LIBRA RC347.5 .M65 2005
Available from offsite location
- Format:
- Book
- Language:
- English
- Subjects (All):
- Neurotoxic agents--Therapeutic use.
- Drug targeting.
- Antibody-toxin conjugates--Therapeutic use.
- Immunotoxins--therapeutic use.
- Antibodies, Monoclonal--therapeutic use.
- Cholinergic Fibers--metabolism.
- Neurobiology--methods.
- Neurons--pathology.
- Antibody-toxin conjugates.
- Neurotoxic agents.
- Medical Subjects:
- Immunotoxins--therapeutic use.
- Antibodies, Monoclonal--therapeutic use.
- Cholinergic Fibers--metabolism.
- Neurobiology--methods.
- Neurons--pathology.
- Physical Description:
- xi, 311 pages : illustrations (partly color) ; 24 cm
- Place of Publication:
- Totowa, N.J. : Humana Press, [2005]
- Summary:
- Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.
- Contents:
- Introduction to molecular neurosurgery / Ronald G. Wiley and Douglas A. Lappi
- Ribosome-inactivating proteins / Fiorenzo Stirpe
- Biochemical, physiological, and behavioral characterizations of the cholinergic basal forebrain lesion produced by 192 IgG-saporin / Jerene J. Waite
- Basal forebrain cholinergic lesion by 192 IgG-saporin: a tool to assess the consequences of cortical cholinergic dysfunction in Alzheimer's disease / Reinhard Schliebs
- 192 IgG-saporin-induced partial cortical cholinergic deafferentation as a model for determining the interactions between brain aging and neurodevelopmental defects in the cortical cholinergic input system / Martin Sarter and John P. Bruno
- Exploring the role of acetylcholine in primate cognition using Me20.4 IgG-saporin / Rosalind M. Ridley and Harry F. Baker
- Cortical cholinergic deafferentation induces A-beta deposition: toward a physiological animal model of Alzheimer's disease / Thomas G. Beach ... [et al.]
- Chemical dissection of brain glucoregulatory circuitry / Sue Ritter ... [et al.]
- Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin / Patrice G. Guyenet, Ruth L. Stornetta, and Ann M. Schreihofer
- Saporin conjugates and pain / Ronald G. Wiley and Douglas A. Lappi
- The use of saporin conjugates to dissect neurons responsible for sleep and wakefulness / Carlos Blanco-Centurion ... [et al.]
- Isolectin B4-mediated cytotoxic targeting of sensory neurons / Lucy Vulchanova and Christopher N. Honda
- B fragment of cholera toxin conjugated to saporin / Peter T. O'hara, Kanwarjit Kelley, and Luc Jasmin.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 1588291995
- 159259896X
- OCLC:
- 55955455
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