Molecular neurosurgery with targeted toxins / edited by Ronald G. Wiley and Douglas A. Lappi.

Format:

• Book

Contributor:

• Wiley, Ronald G., 1947-
• Lappi, Douglas A.

Language:

English

Subjects (All):

• Neurotoxic agents--Therapeutic use.
• Drug targeting.
• Antibody-toxin conjugates--Therapeutic use.
• Immunotoxins--therapeutic use.
• Antibodies, Monoclonal--therapeutic use.
• Cholinergic Fibers--metabolism.
• Neurobiology--methods.
• Neurons--pathology.
• Antibody-toxin conjugates.
• Neurotoxic agents.

Medical Subjects:

• Immunotoxins--therapeutic use.
• Antibodies, Monoclonal--therapeutic use.
• Cholinergic Fibers--metabolism.
• Neurobiology--methods.
• Neurons--pathology.

Physical Description:

xi, 311 pages : illustrations (partly color) ; 24 cm

Place of Publication:

Totowa, N.J. : Humana Press, [2005]

Summary:

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail to give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

Contents:

• Introduction to molecular neurosurgery / Ronald G. Wiley and Douglas A. Lappi
• Ribosome-inactivating proteins / Fiorenzo Stirpe
• Biochemical, physiological, and behavioral characterizations of the cholinergic basal forebrain lesion produced by 192 IgG-saporin / Jerene J. Waite
• Basal forebrain cholinergic lesion by 192 IgG-saporin: a tool to assess the consequences of cortical cholinergic dysfunction in Alzheimer's disease / Reinhard Schliebs
• 192 IgG-saporin-induced partial cortical cholinergic deafferentation as a model for determining the interactions between brain aging and neurodevelopmental defects in the cortical cholinergic input system / Martin Sarter and John P. Bruno
• Exploring the role of acetylcholine in primate cognition using Me20.4 IgG-saporin / Rosalind M. Ridley and Harry F. Baker
• Cortical cholinergic deafferentation induces A-beta deposition: toward a physiological animal model of Alzheimer's disease / Thomas G. Beach ... [et al.]
• Chemical dissection of brain glucoregulatory circuitry / Sue Ritter ... [et al.]
• Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin / Patrice G. Guyenet, Ruth L. Stornetta, and Ann M. Schreihofer
• Saporin conjugates and pain / Ronald G. Wiley and Douglas A. Lappi
• The use of saporin conjugates to dissect neurons responsible for sleep and wakefulness / Carlos Blanco-Centurion ... [et al.]
• Isolectin B4-mediated cytotoxic targeting of sensory neurons / Lucy Vulchanova and Christopher N. Honda
• B fragment of cholera toxin conjugated to saporin / Peter T. O'hara, Kanwarjit Kelley, and Luc Jasmin.

Notes:

Includes bibliographical references and index.

ISBN:

• 1588291995
• 159259896X

OCLC:

55955455