Mechanisms of angiogenesis / edited by M. Clauss and G. Breier.

Format:

Book

Contributor:

Clauss, M. (Matthias), 1954-

Breier, G. (Georg), 1958-

Series:

EXS ; 94.

EXS ; 94

Language:

English

Subjects (All):

Neovascularization.

Neovascularization, Pathologic.

Neovascularization, Physiologic.

Medical Subjects:

Neovascularization, Pathologic.

Neovascularization, Physiologic.

Physical Description:

xiv, 307 pages, 12 pages of plates : illustrations (some color) ; 24 cm.

Place of Publication:

Basel ; Boston, MA : Birkhauser Verlag, [2005]

Summary:

The induction of blood vessel growth - angiogenesis - as part of an adaptive process can be either exaggerated, such as in tumors, or too slow, as in ischemic diseases of heart and brain. Therefore, angiogenesis recently emerged as an appealing target for medical intervention. This volume presents a thorough reconsideration of our current knowledge of factors and principles involved in angiogenic processes. It proceeds from a macroscopic perspective through cellular and physical mechanisms to the molecular levels of growth factors and signal transduction.

This book is subdivided into three main chapters: the first chapter elucidates principles of angiogenesis in physiological as well as pathological conditions. It summarizes the currently known mechanisms from sprouting angiogenesis to arteriogenesis. The second chapter deals with cellular and physical mechanisms leading to angiogenesis. It addresses the multicellular interactions in angiogenesis, adapts the attractive concept of vascular progenitors and embraces the importance of physical forces. The last chapter presents a deeper insight into molecular mechanisms of blood vessel growth, reaching from the identification of signaling steps in angiogenesis to the concept that angiogenesis is a complex event which involves the orchestral setting of several growth factors and is connected to inflammation and coagulation.

Contents:

Basic principles in physiological and pathophysiological angiogenesis

How do endothelial cells orientate? / Holger Gerhardt, Christer Betsholtz 3

New insights into intussusceptive angiogenesis / Valentin Djonov, Andrew N. Makanya 17

Angiogenesis in the female reproductive system / Hellmut G. Augustin 35

Arterialization, coronariogenesis and arteriogenesis / Borja Fernandez 53

Sprouting angiogenesis versus co-option in tumor angiogenesis / Robert M.W. de Waal, William P.J. Leenders 65

Hormones and the neovascularization process: role of angiotensin II / Jean-Sebastien Silvestre, Bernard I. Levy 77

Can tumor angiogenesis be inhibited without resistance? / Kathy D. Miller, Christopher J. Sweeney, George W. Sledge, Jr 95

Cellular and physical mechanisms of blood vessel growth

Role of pericytes in vascular morphogenesis / Christer Betsholtz, Per Lindblom, Holger Gerhardt 115

Role of monocytes and macrophages in angiogenesis / Leni Moldovan, Nicanor I. Moldovan 127

Bone marrow-derived endothelial progenitor cells for neovascular formation / Hiromi Nishimura, Takayuki Asahara 147

Can angiogenesis be exercised? / Jalees Rehman 155

Angiogenesis - a self-adapting principle in hypoxia / Hugo H. Marti 163

Cellular mechanisms of arteriogenesis / Matthias Heil, Wolfgang Schaper 181

Balancing luminal size and smooth muscle proliferation - a key control point in atherosclerosis and arteriogenesis / Jurgen R. Sindermann, Keith L. March 193

Molecular mechanisms of angiogenesis

The role of VEGF in the regulation of physiological and pathological angiogenesis / Napoleone Ferrara 209

The anti-inflammatory actions of angiopoietin-1 / Gavin Thurston, John S. Rudge, Ella Ioffe, Nicholas Papadopoulos, Christopher Daly, Srilatha Vuthoori, Thomas Daly, Stanley J. Wiegand, George D. Yancopoulos 233

The hemostatic system in angiogenesis / Victor W.M. van Hinsbergh, Pieter Koolwijk, Klaas Hoekman 247

Signal transduction in angiogenesis / Ian Zachary 267.

Notes:

Includes bibliographical references and index.

ISBN:

3764364599

OCLC:

56214723