Genetics of autoimmunity / [editors: Gregory Bock and Jamie Goode].

Format:

Book

Conference/Event

Contributor:

Bock, Gregory.

Goode, Jamie.

Conference Name:

Symposium on Genomics of Autoimmunity (2004 : London, England)

Series:

Novartis Foundation symposium ; 267.

Novartis Foundation symposium ; 267

Language:

English

Subjects (All):

Autoimmunity--Congresses.

Autoimmunity.

Autoimmunity--Genetic aspects--Congresses.

Autoimmune Diseases.

Autoimmune Diseases--genetics.

Medical Subjects:

Autoimmune Diseases.

Autoimmune Diseases--genetics.

Genre:

Conference papers and proceedings.

Physical Description:

viii, 251 pages : illustrations ; 24 cm.

Place of Publication:

Chichester, UK ; Hoboken, NJ, USA : John Wiley, 2005.

Summary:

This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: * descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific * discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.

Contents:

Patterns of genetic variation in humans and mice

Haplotype tagging in pharmacogenetics

Multiple sclerosis: a haplotype association study

Mapping genes for asthma and psoriasis

Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse

The importance of epistatic interactions in the development of autoimmunity

Mapping autoimmune disease genes in humans: lessons from IBD and SLE

A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease

Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus

A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling

Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity

An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells

Large-scale screens for cDNAs with in vivo activity

Genomic mining of new genes and pathways in innate and adaptive immunity.

Notes:

"Symposium on Genomics of Autoimmunity, held at the Novartis Foundation, London, 22-24 June 2004"--Contents p.

Includes bibliographical references and indexes.

ISBN:

0470021373

OCLC:

58604687