Mitochondria and cell death / organized and edited by G.C. Brown, D.G. Nicholls, C.E. Cooper.

Format:

Book

Contributor:

Brown, Guy C.

Nicholls, David G.

Cooper, Chris E.

Series:

Biochemical Society (Great Britain). Symposium. Biochemical Society symposia ; no. 66.

Biochemical Society symposium ; no. 66

Language:

English

Subjects (All):

Apoptosis.

Mitochondria.

Cell Death.

Medical Subjects:

Mitochondria.

Cell Death.

Genre:

Conference papers and proceedings.

Physical Description:

x, 225 pages : illustrations ; 26 cm.

Place of Publication:

Princeton, N.J. : Princeton University Press, [1999]

Summary:

This book is a welcome overview of the involvement of mitochondria in cell death and disease, an extraordinarily active research area of major importance to both basic biology and medical science. Clear and thorough chapters present the current approaches leading research teams are taking to examine the role that mitochondria play in including the death of various cell types, including heart, brain, and liver cells.

The volume is comprehensive in that it examines apoptosis and necrosis from multiple levels and perspectives. As well as covering the genetic and mitochondrial involvement in cell death, it details how mitochondrial dysfunction could result in various neurodegenerative, inflammatory, and ischemic diseases, and the aging process. Researchers and postgraduates throughout the biological and medical sciences -- particularly those investigating the causes and potential treatments of cancers, septic shock, Parkinson's disease, and Alzheimer's disease -- will benefit from this book.

Contents:

Mitochondrial control of apoptosis : an overview / G. Kroemer

Nitric oxide, cytochrome c and mitochondria / G.C. Brown and V. Borutaite

Ceramide induces cytochrome c release from isolated mitochondria / C. Richter and P. Ghafourifar

Bcl-2 and Ca²⁺-mediated mitochondrial dysfunction in neural cell death / A.N. Murphy and G. Fiskum

Mitochondria, NO and neurodegeneration / M.F. Beal

Excitotoxicity and mitochondria / D.G. Nicholls ... [et al.]

Apoptosis and necrosis : different execution of the same death / P. Nicotera, M. Leist and E. Ferrando-May

The mitochondrial permeability transition : the brain's point of view / J.M. Dubinsky ... [et al.]

Mitochondrial dysfunction in Parkinson's disease / J.T. Greenamyre ... [et al.]

Secondary abnormalities of mitochondrial DNA associated with neurodegeneration / S.J. Tabrizi and A.H.V. Schapira

Mutations of the mitochondrial genome : clinical overview and possible pathophysiology of cell damage / S.M. Rothman

In vivo measurements of mitochrondrial function and cell death following hypoxic/ischaemic damage to the new-born brain / C.E. Cooper

Mitochondria in heart ischaemia and aging / R.G. Hansford, N. Tsuchiya and S. Pepe

Mitochondrial dysfunction in sepsis / M. Singer and D. Brealey

The mitochondrial permeability transition pore / M. Crompton ... [et al.]

The mitochondrial permeability transition : its molecular mechanism and role in reperfusion injury / A.P. Halestrap

Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death / J.J. Lemasters ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

0691050260

OCLC:

43493220

Online:

Contributor biographical information

Publisher description