Cancer of the uterus / edited by George Coukos, Stephen C. Rubin.

Format:

Book

Contributor:

Coukos, George.

Rubin, Stephen C.

Language:

English

Subjects (All):

Uterus--Cancer.

Uterus.

Uterine Neoplasms--diagnosis.

Uterine Neoplasms--therapy.

Combined Modality Therapy.

Neoplasm Staging.

Tamoxifen--therapeutic use.

Medical Subjects:

Uterine Neoplasms--diagnosis.

Uterine Neoplasms--therapy.

Combined Modality Therapy.

Neoplasm Staging.

Tamoxifen--therapeutic use.

Physical Description:

xx, 525 pages : illustrations ; 24 cm

Place of Publication:

New York : Marcel Dekker, [2005]

Summary:

This invaluable reference surveys current practices and emerging breakthroughs in the screening, identification, diagnosis, and treatment of uterine and endometrial malignancies-analyzing various signs and symptoms, risk factors, therapeutic options, and ongoing clinical research, as well as the prevention, pathology, and surgical management of early and advanced stages of disease.

With contributions from leading authorities on gynecologic cancers, this guide covers recent advances in the molecular phenotyping of endometrial cancer...reviews the different estrogen and progesterone receptors and their implications in endometrial cancer...considers risk factors for endometrial cancer and examines screening methodologies including pelvic ultrasound and endometrial sampling...compares the predictive value of diagnostic tools including imaging techniques and sampling procedures...discusses the management of the premenopausal patient desiring preservation of her childbearing potential...examines the role of laparoscopically-assisted vaginal hysterectomy and laparoscopic staging in the management of endometrial cancer-including disease outcomes, cost analyses, and procedures for patient selection...studies various chemotherapeutic agents and their efficacy on early, advanced, and recurrent disease...and weighs the risks and benefits of hormone replacement therapy after diagnosis of endometrial cancer or uterine sarcoma-emphasizing tumor type, grade, and stage.

Contents:

1 Molecular Genetics of Uterine Malignancies / Paul J. Goodfellow 1

Genetic and Environmental Factors 3

2 Endometrial Cancer in the Hereditary Nonpolyposis Colorectal Cancer Syndrome / Christina A. Bandera 35

Clinical and Pathologic Features of HNPCC-Related Cancers 36

Genetic Basis of HNPCC 39

Identifying the HNPCC Syndrome 40

Counseling Regarding Screening and Prevention 44

3 Steroid Hormone Receptors in the Normal Endometrium and in Endometrial Cancer / Kimberly K. Leslie, Suzy Davies, Meenakshi Singh, Harriet O. Smith 53

Introduction: Endometrial Cancer and the Link to Steroid Hormones and Steroid Receptors 53

Hormone Receptors in the Normal Endometrium 54

Hormonal Effects and Hormone Receptors in Endometrial Cancer 56

Ligand Binding Assays and Immunohistochemistry to Determine Steroid Receptor Status 58

Cross-Talk and Expression in Endometrial Glands and Stroma 61

Genomic Effects of SRs 62

Receptor Isoforms 63

Non-Genomic Effects of Steroid Hormones Through Membrane and Cytosolic Receptors 67

4 The Effects of Tamoxifen on the Endometrium / Richard R. Barakat 79

Endometrial Carcinoma 80

Histology of Tamoxifen-Associated Uterine Cancer 82

The Role of Screening 86

5 Pathology of Endometrial Hyperplasia and Carcinoma / Brigitte M. Ronnett, Jeffrey D. Seidman, Richard J. Zaino, Lora Hedrick Ellenson, Robert J. Kurman 93

Classification 93

Precursors of Endometrial Carcinoma 96

Endometrioid Carcinoma 108

Serous Carcinoma 124

Clear Cell Carcinoma 131

Mixed Types of Carcinoma 133

Malignant Mesodermal Mixed Tumor (MMMT)/Carcinosarcoma 134

Undifferentiated Carcinoma 136

Molecular Genetics of Endometrial Cancer 136

6 Pathology of Uterine Sarcomas / Michael R. Hendrickson, Teri A. Longacre, Richard L. Kempson 149

Classification of Uterine Mesenchymal, Mixed Mesenchymal, and Epithelial Neoplasms 149

Endometrial Stromal Sarcoma (ESS) 150

Uterine Neoplasms with Sex Cord-like Elements 158

Leiomyosarcoma 162

Undifferentiated ESS 170

Miscellaneous Pure Sarcomas 171

Mixed Mullerian Neoplasms 171

Adenosarcoma 172

Carcinosarcoma 176

7 Clinical Evaluation of Abnormal Uterine Bleeding / Jay M. Cooper, Barbara J. Stegmann 195

History and Physical Examination 196

Etiology 197

Diagnosis 206

8 Conservative Treatment of Endometrial Hyperplasia and Early Endometrial Cancer / Genesis Bowen, Thomas Randall 229

Clinical Characteristics 230

Progestin Therapy 232

Anticipation of Treatment Failure 237

Treatment Regimens 240

9 The Surgical Management of Early Endometrial Cancer / Christina S. Chu 245

Staging 246

Prognostic Factors 248

Surgical Approaches 260

10 The Role of Laparoscopy in the Management of Endometrial Cancer / Joan L. Walker, Robert S. Mannel 275

Demand for Laparoscopic Surgery 275

Surgical Techniques for Laparoscopic Treatment of Endometrial Cancer 280

Current Treatment Algorithms Utilizing Laparoscopy in EC 284

Surgical Candidate Selection 284

Training 288

Potential Benefits of Laparoscopic Surgery 289

Complications of Laparoscopy 291

11 The Role of Primary Surgery in Advanced Endometrial Cancer / Robert E. Bristow, F.J. Montz 305

Theoretical Basis for Cytoreductive Surgery 306

Stage III Endometrial Cancer 307

Stage IV Endometrial Cancer 312

Uterine Papillary Serous Carcinoma/Cancer (UPSC) 317

12 Surgical Management of Recurrent Endometrial Cancer / Nicholas Lambrou, Luis Mendez, Manuel Penalver 327

Pelvic Exenteration 329

Palliation 337

13 Radiation Treatment for Early Stage Endometrial Cancer and Uterine Sarcoma / Perry W. Grigsby 343

Endometrial Cancer 345

Uterine Sarcoma 354

Endometrial Stromal Sarcoma 358

Technique of External Irradiation 360

Techniques for HDR Brachytherapy 361

14 Radiation Treatment of Advanced or Recurrent Endometrial Cancer / Eleanor E. R. Harris 367

Role of Radiation Therapy for Stage III-IV EC 368

Radiation Therapy for Pelvic Recurrence 382

Radiation Therapy for Medically Inoperable Patients 390

15 Systemic Therapies for Endometrial Carcinoma / Brian M. Slomovitz, Karen H. Lu 407

Endometrioid Endometrial Carcinoma (EEC) 408

Hormonal Therapy 413

Uterine Papillary Serous Carcinoma (UPSC) 417

Molecular Therapies 420

16 Targeted Therapy of Endometrial Cancer / David O. Holtz, Ronald Buckanovic, George Coukos 435

Epidermal Growth Factor Receptors 436

Transforming Growth Factors 440

PTEN-PI3 kinase 441

Angiogenesis 444

Invasion and Metastasis 451

17 Management of Uterine Sarcomas / Gregory Sutton, Heidi J. Gray 471

Epidemiology and Incidence 471

Prognostic Factors 473

Surgical Staging of Uterine Sarcomas 474

Adjuvant Chemotherapy in Early Uterine Sarcomas 477

Adjuvant Radiotherapy in Uterine Sarcomas 479

Palliative Chemotherapy in Uterine Sarcomas 480

Hormonal Therapy in Uterine Sarcomas 485

Multimodality Adjuvant Therapy 486

18 Hormone Replacement in the Patient with Uterine Cancer / Kathleen Lin, Carolyn D. Runowicz 495.

Notes:

Includes bibliographical references and index.

ISBN:

0824754158

OCLC:

57422273