Molecular oncology of breast cancer / edited by Jeffrey S. Ross and Gabriel N. Hortobagyi.

Format:

Book

Contributor:

Ross, Jeffrey S. (Jeffrey Stuart), 1945-

Hortobagyi, Gabriel N.

Language:

English

Subjects (All):

Breast--Cancer--Molecular aspects.

Breast.

Breast Neoplasms--diagnosis.

Breast Neoplasms--genetics.

Breast Neoplasms--therapy.

Biomarkers.

Molecular Biology.

Medical Subjects:

Breast Neoplasms--diagnosis.

Breast Neoplasms--genetics.

Breast Neoplasms--therapy.

Biomarkers.

Molecular Biology.

Physical Description:

ix, 500 pages, 15 pages of plates : illustrations (some color) ; 29 cm

Place of Publication:

Sudbury, Mass. : Jones and Bartlett Publishers, [2005]

Summary:

The first comprehensive reference to focus on the molecular development and treatment of the disease, Molecular Oncology of Breast Cancer provides authoritative information across the spectrum of modern breast cancer research and clinical care. Edited by two world-class experts in cancer pathology, drug development, and patient management, with contributions from over 50 experts, this groundbreaking text describes the genes, proteins, and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed breast cancer. For the first time, readers can now obtain, in a single volume, up to date information on how molecular-based tests are being used to identify predisposition, provide earliest detection, decide classification based on genetic fingerprint, and predict therapy-specific outcomes. MOBC includes unique chapters on functional imaging and the impact of targeted therapies on the FDA approval process. This book gives readers vital, up-to-date information on important molecular discoveries that affect the everyday management of the breast cancer patient.

Contents:

Introduction and background / Gabriel N. Hortobagyi

Molecular diagnostic techniques in breast cancer / Jeffrey S. Ross

Clinical and molecular epidemiology of breast cancer / Abenaa Brewster and Melissa Bondy

Predisposition for breast cancer / Marion Kiechle and Alfons Meindl

Screening and early detection, serum and nipple aspirates, routine and molecular methods, including reverse transcriptase-polymerase chain reaction, and proteomics / Douglas P. Malinowski

Genomic and molecular classification of breast cancer / Christos Sotiriou ... [et al.]

Cytology: clinical sample procurement and on-slide technologies / W. Fraser Symmans

Histopathology of breast cancer: correlation with molecular markers / W. Fraser Symmans

Sentinel lymph node dissection and micrometastasis detection in bone marrow and lymph nodes / Volkmar Müller, Sabine Kasimir-Bauer, and Klaus Pantel

Prognostic and predictive factors overview / Jeffrey S. Ross and Nadia Harbeck

Breast cancer cytogenetics, chromosomal abnormalities, and comparative genomic hybridization / Mark Watson and Lynn Cawkwell

DNA ploidy and S phase analysis in breast cancer / Jeffrey S. Ross ... [et al.]

Cell proliferation markers and cell cycle regulators in breast cancer / Jeffrey S. Ross and Carlos Cordon-Cardo

Targeted therapy for cancer: integrating diagnostics and therapeutics / Jeffrey S. Ross

Hormone receptors and hormonal-based therapy

for breast cancer / Jeffrey S. Ross and Gabriel N. Hortobagyi

HER-2/neu gene and protein in breast cancer / Fatima Cardoso ... [et al.]

Epidermal growth factor receptor and other growth factors and receptors / Joan Albanell and Jeffrey S. Ross

Tumor-associated proteolytic factors: markers for tumor invasion and metastasis / Nadia Harbeck ... [et al.]

Breast cancer and angiogenesis / Manfred Schmitt, Nadia Harbeck, and Jeffrey S. Ross

Cell adhesion markers / Heinz Höfler and Birgit Luber

Programmed cell death and breast cancer / Xiao-Ming Yin and Gerald P. Linette

Oncogenes / Andre M. Oliveira and Jonathan A. Fletcher

p53 and tumor suppressor genes in breast cancer / Andre M. Oliveira, Jeffrey S. Ross, and Jonathan A. Fletcher

The ubiquitin-proteasome pathway and breast cancer / Robert Z. Orlowski

DNA repair and the maintenance of genomic stability in breast cancer / Jennifer E. Quinn, Richard D. Kennedy, and D. Paul Harkin

Biologic and clinical significance of DNA gene methylation and epigenetic events in breast cancer / Manel Esteller and Esteban Ballestar

DNA methylation in breast cancer as diagnostic markers and targets for cancer therapy / Sabine Maier ... [et al.]

Pharmacogenetics, pharmacogenomics, and predicting response to therapy / Lajos Pusztai ... [et al.]

Mammography and molecular imaging / Hernan I. Vargas, M. Perla Vargas, and Iraj Khalkhali

Translation of molecular

markers to clinical practice / Nadia Harbeck, Christoph Thomssen, and Ronald E. Kates

Regulatory aspects and implications of molecular testing in the United States / Robert Pietrusko.

Notes:

Includes bibliographical references and index.

ISBN:

0763748102

OCLC:

56591254