Chirality in drug design and development / edited by Indra K. Reddy, Reza Mehvar.

Format:

Book

Contributor:

Reddy, Indra K.

Miḥvar, Riz̤ā

Alumni and Friends Memorial Book Fund.

Language:

English

Subjects (All):

Chiral drugs.

Drugs--Design.

Drugs.

Drug development.

Physical Description:

xii, 444 pages : illustrations ; 24 cm

Place of Publication:

New York ; Basel : Marcel Dekker, [2004]

Contents:

1. Effects of Crystal Structure and Physical Properties on the Release of Chiral Drugs / Chong-Hui Gu, David J. W. Grant 1

2. Use of Chiral Excipients in Formulations Containing Chiral Drugs / Moji Christianah Adeyeye 37

3. Transport of Chiral Molecules Across the Skin / Elka Touitou, Biana Godin, Thirumala R. Kommuru, Mohsen I. Afounda, Indra K. Reddy 67

4. Stereoselective Drug Delivery Through Prodrug Approach / Teruko Imai, Masaki Otagiri 101

5. Stereoselectivity in Drug Action and Disposition: An Overview / Bhavesh K. Patel, Andrew J. Hutt 139

6. Stereospecific Pharmacokinetics and Pharmacodynamics: Selected Classes of Drugs / Dion R. Brocks, Majid Vakily, Reza Mehvar 191

7. Stereospecific Pharmacokinetics and Pharmacodynamics: Cardiovascular Drugs / Reza Mehvar, Dion R. Brocks 281

8. Chiral Inversion / Neal M. Davies 351

9. Bioequivalency Determination of Racemic Drug Formulations: Is Stereospecific Assay Essential? / Aziz Karim, Cherukury Madhu, Chyung Cook 393

10. Regulatory Considerations in Drug Development of Stereoisomers / Chandra Sahajwalla 419.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

0824750624

OCLC:

54904697