Mouse models of human cancer / edited by Eric C. Holland.

Format:

Book

Contributor:

Holland, Eric C.

Language:

English

Subjects (All):

Cancer--Animal models.

Cancer.

Mice--Diseases--Pathophysiology.

Mice.

Disease Models, Animal.

Neoplasms--physiopathology.

Animals, Genetically Modified.

Antineoplastic Agents.

Drug Evaluation, Preclinical.

Mice, Inbred Strains.

Mice--Diseases.

Physiology, Pathological.

Medical Subjects:

Disease Models, Animal.

Neoplasms--physiopathology.

Animals, Genetically Modified.

Antineoplastic Agents.

Drug Evaluation, Preclinical.

Mice, Inbred Strains.

Physical Description:

xi, 474 pages, 8 unnumbered pages of plates : illustrations (some color) ; 29 cm

Place of Publication:

Hoboken, N.J. : Wiley-Liss, [2004]

Summary:

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Contents:

Approaches to handling, breeding, strain preservation, genotyping, and drug administration for mouse models of cancer / Dawnalyn Boggess ... [et al.]

Pathology of mouse models of cancer / Robert D. Cardiff

Intercurrent infections in genetically engineered mice / Stephen W. Barthold

Germline modification strategies / Silvia Grisendi and Pier Paolo Pandolfi

Somatic cell gene transfer / Lene Uhrbom and Eric C. Holland

Lung cancer / Jonathan M. Kurie ... [et al.]

Mammary gland cancer / Dalit Barkan ... [et al.]

Prostate cancer / Katharine Ellwood-Yen and Charles Sawyers

Skin cancer / Marcus Bosenberg

Ovarian cancer / Sandra Orsulic

Peripheral nervous system tumors / David H. Gutmann ... [et al.]

Central nervous system tumors / Andrew B. Lassman and Eric C. Holland

Myeloid malignancies / Scott C. Kogan

Lymphoid malignancies / Michael Teitell and Pier Paolo Pandolfi

Genetic modifiers / David W. Threadgill ... [et al.]

Modeling blood vessel formation in the mouse / Robert Benezra, Shahin Rafii, and David Lyden

Metastasis / Dawn S. Chandler and Guillermina Lozano

Immunologic study of tumors in mouse models / Taha Merghoub and Alan N. Houghton

Micro-computed tomography of mouse cancer models / Jamey P. Weichert

Magnetic resonance imaging in mouse cancer models / Manickam Muruganandham and Jason A. Koutcher

Bioluminescent imaging of mouse cancer models / Christopher H. Contag

Use of magnetic resonance imaging for evaluation treatment response / Brian D. Ross ... [et al.]

Physiologically based pharmacokinetic and pharmacodynamic modeling / Raymond S. H. Yang ... [et al.]

Trial design and biostatistics / Michael F.W. Festing

Cancer drug development in the modern era / William R. Sellers and Alex Matter

Preclinical trials in mouse cancer models / Brian Weiss and Kevin Shannon.

Notes:

Includes bibliographical references and index.

ISBN:

047144460X

OCLC:

53937807

Online:

Publisher description