Protein kinase C / [edited by] Lodewijk V. Dekker.

Format:

Book

Contributor:

Dekker, Lodewijk V.

Series:

Molecular biology intelligence unit (Unnumbered)

Molecular biology intelligence unit

Language:

English

Subjects (All):

Protein kinase C.

Protein Kinase C.

Medical Subjects:

Protein Kinase C.

Physical Description:

194 pages : illustrations ; 24 cm.

Edition:

Second edition.

Place of Publication:

Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York : Kluwer Academic/Plenum Publishers, [2004]

Summary:

Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. In this book, the most significant advances in recent basic research on Protein Kinase C are explained by active researchers in the field. The first seven chapters provide a comprehensive account of the fundamental structural and biochemical properties of Protein Kinase C. The remaining chapters contain overviews of the function of Protein Kinase C, both in lower organisms and in mammalian cells, the latter with a focus on immune cells and nerve cells. This book is the only recent publication devoted entirely to Protein Kinase C and forms a major point of reference for those active in the field. In addition it will appeal to those with a general interest in biochemistry, cell biology, immunology and neurobiology.

Contents:

The Protein Phosphorylation Reaction 1

Protein Kinases 1

Protein Kinase C 2

Protein Kinase C Isotypes and Their Domain Structure 2

Defining the PKC Family 4

This Book 5

2. Structure, Function and Membrane Interactions of C1 Domains / Matthew Pearson, James H. Hurley 8

C1 Domain Structure and Stereospecific Ligand Recognition 9

Membrane Binding and Subcellular Localization of C1 Domains 11

Typical C1 Domains in Proteins Other than PKC 12

Atypical C1 Domains 12

C1 Domains in the Context of Multidomain Signaling Proteins 13

3. Structural and Functional Specialization of C2 Domains in Protein Kinase C / Eric A. Nalefski 16

C2 Domain Structure 17

C2 Domain Interactions with Ligands 20

Mechanism of Membrane Targeting of PKC by C2 Domains 25

4. Regulation of Protein Kinase C by Membrane Interactions / Alexandra C. Newton 36

Protein Kinase C: At the Heart of Lipid Signalling 36

The Three Cofactors: Phosphatidylserine, Diacylglycerol, and Ca[superscript 2+] 37

Translocation of Protein Kinase C 42

Phosphorylation: Regulator of Protein Kinase C's Subcellular Location 44

5. Protein Kinase C Regulation by Protein Interactions / Susan Jaken 49

Examples of PKC Binding Proteins 51

6. Regulation of Protein Kinase C by Phosphorylation / Alex Toker 63

Phosphorylation at the Activation Loop 64

Phosphorylation at the Turn Motif 67

Phosphorylation at the Hydrophobic Site 68

The Role of the Phosphoinositide 3-Kinase Pathway 69

Regulation by Dephosphorylation 70

Implications for Cellular Function 71

Regulation of Protein Kinase C by Tyrosine Phosphorylation 71

7. Down-Regulation of Protein Kinase C / Nigel T. Goode, Nicola Smart 76

The Proteolytic Mechanism 78

Role of Down-Regulation 82

8. Protein Kinase C in Yeast: The Cell Wall Integrity Pathway / Pilar Perez, Beatriz Santos, Pedro M. Coll 87

Yeasts PKC Homologues 87

Rho GTPases and PKC Activation 88

S. cerevisiae Pkc1p and the Cell Integrity Pathway 90

Cell Integrity Pathway and Cell Cycle 91

Interaction with Other Pathways 93

Function of Pck1p and Pck2p in S. pombe Cell Integrity and Cell Wall Biosynthesis 93

9. Specificity in Atypical Protein Kinase C Signaling: The NF-[kappa]B Paradigm / Jorge Moscat, Maria T. Diaz-Meco 100

The NF-[kappa]B Pathway 100

Adapters for the aPKCs to NF-[kappa]B Activation 103

Functional Relevance of the aPKCs in the Ras-NF-[kappa]B Crossroad 106

Specificity during Cell Signaling 106

Blockade of NF-[kappa]B by the Endogenous aPKC Inhibitor Par-4 109

10. Protein Kinase C: A Molecular Information Storage Device in Neurons / Laura A. Schrader, Coleen M. Atkins, Michael Leitges, J. David Sweatt, Edwin J. Weber 114

Activity-Dependent Synaptic Plasticity 114

Inhibitors of PKC Block LTP 116

Activating PKC Mimics LTP 117

Biochemical Studies 118

Oxidative Modification of PKC 118

Protein Kinase Substrates Phosphorylated during LTP 119

Cerebellar Long-Term Depression 121

PKC in Learning and Memory 121

Changes in Activity, Cellular Distribution and Phosphorylation of Substrates 122

Pharmacological Inhibition of PKC 123

Isotype Specific PKC Knockout 123

11. Involvement of PKC in the Sensation of Pain / Vittorio Vellani, Peter A. McNaughton 134

Role of PKC in Peripheral Nociception 136

Sensitization of the Heat-Gated Current by PKC 136

Desensitization of VR1 by Calcineurin 138

Phosphorylation of VR1 138

PKC Isotypes Involved in VR1 Phosphorylation 139

PKC-[varepsilon] and Inflammatory Pain 139

Actions of PKC on Voltage-Sensitive Na Currents 140

Specific Involvement of PKC-[varepsilon] in Neuropathic Pain 141

Conclusion: Peripheral Nociception 141

Involvement of PKC in Central Pain Processing 141

Protein Kinase C-[gamma] and Persistent Pain 142

PKC Activity, Opioid Tolerance and Pathological Pain States Are Related 142

12. The Protein Kinase C Gene Module: Cellular Functions in T Lymphocytes / Gottfried Baier 147

The PKC Kinases: A Gene Family of Nine Isotypes 147

Regulation of PKC Activity in T Cells 149

Signaling Specificity of PKC in T Cells

A Complex Affair 150

Role of PKC in T Lymphocyte Physiology 153

PKC and T Cell Activation 153

T Cell Antigen Receptor 153

Integrin Receptors 155

Cytokine Receptors 156

Are There any Other Critical Pathways Modulated by PKC 157

Role of PKC in Lymphocyte Development 157

Role of PKC in Lymphocyte Homeostasis 158

PKCs in Lymphocyte Disorders 159

Synopsis and Future Perspectives 159

13. Protein Kinase C Isotype Function in Neutrophils / Lodewijk V. Dekker 165

Basic Cell Biological Properties of Neutrophils 165

PKC Isotypes in Neutrophils 168

Studying PKC Isotype Function in Neutrophils 171

Molecular Targets of PKC in Neutrophils 173.

Notes:

Includes bibliographical references and index.

ISBN:

0306478633

OCLC:

54966162