Obesity and diabetes / editors, Anthony H. Barnett, Sudhesh Kumar.

Format:

Book

Contributor:

Barnett, A. H. (Anthony H.), 1951-

Kumar, Sudhesh.

Series:

Diabetes in practice

Wiley diabetes in practice series

Language:

English

Subjects (All):

Obesity.

Type 2 diabetes.

Diabetes Mellitus, Type 2--etiology.

Obesity--complications.

Diabetes Mellitus, Type 2--epidemiology.

Diabetes Mellitus, Type 2--therapy.

Obesity--therapy.

Medical Subjects:

Diabetes Mellitus, Type 2--etiology.

Obesity--complications.

Diabetes Mellitus, Type 2--epidemiology.

Diabetes Mellitus, Type 2--therapy.

Obesity--therapy.

Physical Description:

xv, 308 pages : illustrations ; 26 cm.

Other Title:

Obesity & diabetes

Place of Publication:

Chichester, England ; Hoboken, NJ : John Wiley & Sons, [2004]

Summary:

Obesity has become the most common chronic disease of the present day, with significant increases in prevalence in populations across the world and all age groups. This has resulted in a dramatic increase in obesity-related metabolic and cardiovascular complications, making it an important public health issue. Type 2 diabetes associated with obesity or 'diabesity' is today the most common form of diabetes. It is also associated with a number of other cardiovascular risk factors which constitute the metabolic syndrome. Effective management of 'diabesity' is crucial to the reduction of morbidity and premature mortality due to cardiovascular disease.

This book comprises chapters written by leading international experts on various aspects of obesity-related diabetes. It will serve as a practical reference guide suitable for all professionals with an interest in this field. The early chapters cover topics ranging from the changing epidemiology of type 2 diabetes to an analysis of the principal causes of the metabolic syndrome. Emerging problems such as childhood 'diabesity' and the impact of obesity on polycystic ovary syndrome will be of interest not only to paediatricians and endocrinologists, but also to general practitioners and other healthcare professionals. The contemporary approach to the clinical assessment of obesity and its management in both primary and secondary care settings is described. The book features many suggestions of practical value.

Contents:

1 Changing Epidemiology of Obesity - Implications for Diabetes / Jonathan Webber 1

Assessment of obesity in epidemiological studies 1

Prevalence of obesity 2

The epidemiological link between obesity and diabetes 3

Factors modifying the relationship between obesity and diabetes 5

2 The Genetics of Human Obesity / Victor J. Lawrence, Tahseen Choudhury 13

Why has the genetics of obesity been difficult to study? 13

How much of obesity is genetic? 15

Is there a major gene for obesity? 17

How to identify obesity genes 18

3 Lifestyle Determinants of Obesity / Susan A. Jebb, Jeremy Krebs 33

The importance of energy balance 33

Physical activity 34

Energy intake 35

Environmental impacts on lifestyle 41

An integrated analysis 42

4 Pathogenesis of Obesity-Related Type 2 Diabetes / Philip McTernan, Sudhesh Kumar 49

Defining fat accumulation in terms of health risk 50

Implications of obesity-associated diabetes 51

Development of obesity-related type 2 diabetes 51

Fat distribution 54

Evaluating obesity-related hypotheses for progression of type 2 diabetes 55

Ectopic fat storage: fat content in obesity 56

Lipid metabolism in adipose tissue 58

Effects of NEFA on hepatic insulin action 61

Adipose-tissue derived factors 62

5 Obesity and Prevention of Type 2 Diabetes / Jaakko Tuomilehto, Jaana Lindstrom, Karri Silventoinen 79

Obesity and the risk of type 2 diabetes 79

Lifestyle intervention studies 83

Other intervention studies 88

6 Diet and Food-based Therapies for Obesity in Diabetic Patients / Iain Broom 99

Type 2 diabetes 99

Patterns of weight loss in diabetes 100

Target setting 101

Dietary and lifestyle alterations 101

Dietary nutrient composition in type 2 diabetes 102

The approach to dietary prescription 104

Failure of therapy 105

Fat or carbohydrate 105

Meal replacement therapy 108

Very low calorie diets (VLCD) 108

7 Behavioural Modification in the Treatment of Obesity / Brent Van Dorsten 111

Genetics 112

The 'toxic environment' 112

Components of obesity treatment 113

Features of behavioural lifestyle change 114

Behavioural modification strategies in obesity treatment 116

Efficacy of combination treatments 121

8 Physical Activity, Obesity and Type 2 Diabetes / Carlton B. Cooke, Paul J. Gately 131

Physical activity and exercise, what is the difference? 132

Current physical activity behaviour and guidelines 133

The importance of physical activity to health 135

Energy balance 138

Energy expenditure 139

Exercise tolerance and cardiorespiratory fitness in overweight and obese adults and children 145

Guidelines for exercise and activity prescription (including practical issues of clinical management for diabetics and the obese) 147

Research evidence on the role of physical activity in the prevention and treatment of obesity and type 2 diabetes 149

Physical activity and the behavioural treatment of obesity 155

Linking research and practice 156

9 Diabetes, Obesity and Cardiovascular Disease - Therapeutic Implications / Jayadave Shakher, Anthony H. Barnett 167

Obesity and mortality 168

Obesity and cardiovascular disease 168

Obesity and hypertension 169

Obesity and dyslipidaemia 170

Obesity, type 2 diabetes and insulin resistance 172

Obesity and type 2 diabetes 174

Insulin resistance and cardiovascular disease 175

Type 2 diabetes and dyslipidaemia 178

Type 2 diabetes and hypertension 179

Type 2 diabetes and CHD 179

Benefits of weight loss 182

Pharmacotherapy 183

Management of hypertension 183

Management of dyslipidaemia 186

Antiplatelet therapy 189

10 Drug Therapy for the Obese Diabetic Patient / John P. H. Wilding 201

Drugs for hyperglycaemia 201

The role of anti-obesity drugs in diabetic management 206

Antihypertensive treatment 209

Lipid-lowering treatment 210

Use of other drugs that may cause weight gain 210

11 The Role of Bariatric Surgery in the Management of Type 2 Diabetes / David D. Kerrigan, James Evans, John Pinkney 215

Obesity and type 2 diabetes 215

Surgical techniques 216

Resolution of diabetes after bariatric surgery 221

How does surgery 'cure' diabetes? 222

12 Childhood Obesity and Type 2 Diabetes / Krystyna A. Matyka, Timothy Barrett 233

Childhood is a time of change 233

The problem of size 234

The size of the problem 236

What causes obesity in childhood? 236

Does obesity in childhood matter? 239

Persistence in to adult life 248

Management of childhood obesity 248

Management of Complications 252

13 Obesity and Polycystic Ovary Syndrome / Diana Raskauskiene, Richard N. Clayton 261

Definition of the syndrome 261

Pathogenetic mechanisms underlying the relationship between obesity and PCOS (Table 13.1) 262

Clinical features of obese PCOS women 270

Treatment of obese women with PCOS (Table 13.2) 274

14 Management of Diabesity in Primary Care: a Multidisciplinary Approach / Ian W. Campbell 285

Prevalence of obesity in primary care 285

Current approach to diabetes care in primary care 286

Early treatment with hypoglycaemic agents 287

Integrating obesity management with diabetes 287

A multidisciplinary approach 287

Dietary treatment of diabetes 288

Clinical assessment 290

Treatment groups 290

Physical activity 291

Behavioural change 293

Use of medication to aid weight loss in primary care 294.

Notes:

Includes bibliographical references and index.

ISBN:

0470848987

OCLC:

55228268

Online:

Publisher description