Multiple myeloma and related disorders / edited by Gösta Gahrton, Brian G. M. Durie, and Diana M. Samson.

Format:

Book

Contributor:

Gahrton, Gösta.

Durie, Brian G. M.

Samson, Diana M.

Language:

English

Subjects (All):

Multiple myeloma.

Multiple Myeloma.

Immunoproliferative Disorders.

Medical Subjects:

Multiple Myeloma.

Immunoproliferative Disorders.

Physical Description:

xiii, 466 pages, 8 unnumbered pages of plates : illustrations (some color) ; 28 cm

Place of Publication:

London : Arnold ; New York, NY : Distributed in the United States of America by Oxford University Press, 2004.

Summary:

During the past decade there has been an enormous increase in knowledge of multiple myeloma and related disorders, reflected in the publication of more than 5000 articles on the subject in scientific journals. Much of this has come about as new technologies have made it possible to refine studies on chromosomes and genes, and to gain information about gene expression. Microarray is in its early stages, but already there have been pattern descriptions that may have prognostic implications. The impact of chromosomal abnormalities is now clearer than before, and the complicated interaction between the stromal cells, the myeloma cells, and numerous cytokines and their receptors has been better explained. Attempts have been made to utilize this new knowledge to develop targeted therapy and, although results are still modest, improvements have been obtained with thalidomide and analogues, as well as with proteasome inhibitors. It is therefore highly appropriate that this new comprehensive reference should appear at this time. The book covers the whole field of multiple myeloma, and also related diseases such as Waldenstrom's macroglobulinemia, AL amyloidosis and plasma cell leukemia, and incorporates both the basic science underlying the biology of these diseases and their clinical management. Each chapter has been written to 'stand alone', allowing the reader to dip into a particular subject and find information quickly without the need to browse through multiple chapters. In addition to the developments described above, many other aspects of multiple myeloma are reviewed.

Contents:

Part 1 History and Epidemiology 1

1 History of multiple myeloma / Robert A. Kyle, David P. Steensma 3

2 Epidemiology and etiology of plasma cell neoplasms / Daniel E. Bergsagel, P. Leif Bergsagel 15

Part 2 Biology and Pathophysiology 27

3 The immune system in myeloma / Douglas E. Joshua, P. Joy Ho, John Gibson, Ross D. Brown 29

4 Molecular biology and cytogenetics / Johannes Drach, Jutta Ackermann, Sonja Seidl, Hannes Kaufmann 46

5 Biology of the malignant plasma cell / Federico Caligaris-Cappio 58

6 Pathophysiology of myeloma bone disease / Babatunde O. Oyajobi, Gregory R. Mundy 74

Part 3 Clinical Features, Diagnosis, and Investigation 89

7 Clinical features / Dietrich Peest 91

8 Hematologic investigations: morphologic and phenotypic features of myeloma marrow diagnosis / Thomas M. Grogan, Deborah Gelbspan, Lisa Rimsza 102

9 Biochemical and immunological investigations / Joanna M. Sheldon, Pamela G. Riches 125

10 The role of imaging in multiple myeloma / Brian G.M. Durie 155

11 Innovative approaches for diagnosis and monitoring / Faith E. Davies, Gareth J. Morgan 164

12 Multiple myeloma: differential diagnosis and prognosis / Jesus F. San Miguel, Ramon Garcia-Sanz 179

Part 4 Treatment of Myeloma 201

13 Principles of management / Diana M. Samson 203

14 Chemotherapy, steroids, and interferon / Diana M. Samson 220

15 Radiotherapy / Deborah A. Frassica, Maria C. Jacobs 241

16 Autologous stem cell transplantation / Jean-Luc Harousseau, Michel Attal 250

17 Allogeneic transplantation and treatment with donor lymphocytes / Gosta Gahrton, Per Ljungman 260

18 Supportive care / Heinz Ludwig, Johannes Drach 275

19 Biological basis of therapy: new molecular targets / Terry H. Landowski, William S. Dalton 292

20 Immunotherapeutic approaches / Hakan Mellstedt 305

Part 5 Complications 317

21 Management of bone disease / Eugene V. McCloskey 319

22 Management of myeloma patients with renal failure / Joan Blade, Laura Rosinol 339

23 Neurologic aspects of monoclonal gammopathy of undetermined significance, multiple myeloma, and related disorders / Robert A. Kyle, Angela Dispenzieri 350

Part 6 Related Disorders 367

24 Monoclonal gammopathies of undetermined significance: the transition from MGUS to myeloma / John A. Lust Kathleen A. Donovan, Philip R. Greipp 369

25 Solitary bone and extramedullary plasmacytoma / Meletios A. Dimopoulos, Lia A. Moulopoulos 379

26 Plasma cell leukaemia / Xavier Leleu, Ibrahim Yakoub-Agha, Thierry Facon 388

27 AL amyloidosis / Raymond L. Comenzo 400

28 Heavy-chain diseases / Jean-Paul Fermand, Jean-Claude Brouet 420

29 Waldenstrom's disease / Giampaolo Merlini, Steven P. Treon 429.

Notes:

Includes bibliographical references and index.

ISBN:

0340810106

OCLC:

56066244