Biochemistry / Donald Voet, Judith G. Voet.

Format:

Book

Author/Creator:

Voet, Donald.

Contributor:

Voet, Judith G.

Alumni and Friends Memorial Book Fund.

Language:

English

Subjects (All):

Biochemistry.

Medical Subjects:

Biochemistry.

Physical Description:

xv, 1591 pages : illustrations (some color) ; 29 cm + 1 CD-ROM (4 3/4 in.)

Edition:

Third edition.

Other Title:

Title of accompanying CD-ROM: Biochemical interactions to accompany Voet & Voet Biochemistry 3rd edition. Version 3.2

Place of Publication:

New York : J. Wiley & Sons, [2004]

System Details:

System requirements for accompanying CD-ROM: IBM PC or compatible with Windows 3.1; Macintosh computer.

Summary:

This title has not appeared in Preview, but was published in July 2002. Biochemistry 3rd edition DONALD VOET, University of Pennsylvania, USA and JUDITH G. VOET, Swarthmore College, USA Biochemistry is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. * This edition has been updated to reflect the enormous advances in molecular and protein structure * Integrated Biochemical Interactions CD

Contents:

Chapter 1 Life 3

1. Prokaryotes 3

2. Eukaryotes 7

3. Biochemistry: A Prologue 14

4. Genetics: A Review 19

5. The Origin of Life 28

6. The Biochemical Literature 34

Chapter 2 Aqueous Solutions 39

1. Properties of Water 39

2. Acids, Bases, and Buffers 44

Chapter 3 Thermodynamic Principles: A Review 51

1. First Law of Thermodynamics: Energy Is Conserved 52

2. Second Law of Thermodynamics: The Universe Tends toward Maximum Disorder 53

3. Free Energy: The Indicator of Spontaneity 56

4. Chemical Equilibria 57

Appendix Concentration Dependence of Free Energy 60

Part II Biomolecules 63

Chapter 4 Amino Acids 65

1. The Amino Acids of Proteins 65

2. Optical Activity 71

3. "Nonstandard" Amino Acids 76

Chapter 5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 80

1. Nucleotides and Nucleic Acids 80

2. DNA Is the Carrier of Genetic Information 82

3. Double Helical DNA 85

4. Gene Expression and Replication: An Overview 92

5. Molecular Cloning 101

Chapter 6 Techniques of Protein and Nucleic Acid Purification 127

1. Protein Isolation 127

2. Solubilities of Proteins 131

3. Chromatographic Separations 133

4. Electrophoresis 144

5. Ultracentrifugation 151

6. Nucleic Acid Fractionation 155

Chapter 7 Covalent Structures of Proteins and Nucleic Acids 161

1. Primary Structure Determination of Proteins 162

2. Nucleic Acid Sequencing 175

3. Chemical Evolution 182

4. Bioinformatics: An Introduction 191

5. Chemical Synthesis of Polypeptides 203

6. Chemical Synthesis of Oligonucleotides 207

Chapter 8 Three-Dimensional Structures of Proteins 219

1. Secondary Structure 219

2. Fibrous Proteins 231

3. Globular Proteins 240

4. Protein Stability 258

5. Quaternary Structure 265

Appendix Viewing Stereo Pictures 269

Chapter 9 Protein Folding, Dynamics, and Structural Evolution 276

1. Protein Folding: Theory and Experiment 276

2. Folding Accessory Proteins 288

3. Protein Structure Prediction and Design 299

4. Protein Dynamics 302

5. Conformational Diseases: Amyloids and Prions 306

6. Structural Evolution 312

Chapter 10 Hemoglobin: Protein Function in Microcosm 320

1. Hemoglobin Function 320

2. Structure and Mechanism 327

3. Abnormal Hemoglobins 339

4. Allosteric Regulation 345

Appendix Derivation of Symmetry Model Equations 352

Chapter 11 Sugars and Polysaccharides 356

1. Monosaccharides 356

2. Polysaccharides 362

3. Glycoproteins 369

Chapter 12 Lipids and Membranes 382

1. Lipid Classification 382

2. Properties of Lipid Aggregates 389

3. Biological Membranes 394

4. Membrane Assembly and protein Targeting 414

5. Lipoproteins 439

Part III Mechanisms of Enzyme Action 457

Chapter 13 Introduction to Enzymes 459

1. Historical Perspective 459

2. Substrate Specificity 460

3. Coenzymes 463

4. Regulation of Enzymatic Activity 465

5. A Primer of Enzyme Nomenclature 470

Chapter 14 Rates of Enzymatic Reactions 472

1. Chemical Kinetics 473

2. Enzyme Kinetics 477

3. Inhibition 482

4. Effects of pH 486

5. Bisubstrate Reactions 487

Appendix Derivations of Michaelis-Menten Equation Variants 491

Chapter 15 Enzymatic Catalysis 496

1. Catalytic Mechanisms 496

2. Lysozyme 507

3. Serine Proteases 515

4. Drug Design 528

Part IV Metabolism 547

Chapter 16 Introduction to Metabolism 549

1. Metabolic Pathways 549

2. Organic Reaction Mechanisms 552

3. Experimental Approaches to the Study of Metabolism 559

4. Thermodynamics of Phosphate Compounds 566

5. Oxidation-Reduction Reactions 571

6. Thermodynamics of Life 574

Chapter 17 Glycolysis 581

1. The Glycolytic Pathway 582

2. The Reactions of Glycolysis 585

3. Fermentation: The Anaerobic Fate of Pyruvate 602

4. Metabolic Regulation and Control 607

5. Metabolism of Hexoses Other than Glucose 618

Chapter 18 Glycogen Metabolism 626

1. Glycogen Breakdown 626

2. Glycogen Synthesis 632

3. Control of Glycogen Metabolism 635

4. Glycogen Storage Diseases 651

Chapter 19 Signal Transduction 657

1. Hormones 657

2. Heterotrimeric G Proteins 673

3. Tyrosine Kinase-Based Signaling 683

4. The Phosphoinositide Cascade 707

Chapter 20 Transport through Membranes 726

1. Thermodynamics of Transport 726

2. Kinetics and Mechanisms of Transport 727

3. ATP-Driven Active Transport 738

4. Ion Gradient-Driven Active Transport 746

5. Neurotransmission 750

Chapter 21 Citric Acid Cycle 765

1. Cycle Overview 765

2. Metabolic Sources of Acetyl-Coenzyme A 768

3. Enzymes of the Citric Acid Cycle 781

4. Regulation of the Citric Acid Cycle 790

5. The Amphibolic Nature of the Citric Acid Cycle 792

Chapter 22 Electron Transport and Oxidative Phosphorylation 797

1. The Mitochondrion 798

2. Electron Transport 802

3. Oxidative Phosphorylation 820

4. Control of ATP Production 836

Chapter 23 Other Pathways of Carbohydrate Metabolism 843

1. Gluconeogenesis 843

2. The Glyoxylate Cycle 850

3. Biosynthesis of Oligosaccharides and Glycoproteins 852

4. The Pentose Phosphate Pathway 862

Chapter 24 Photosynthesis 871

1. Chloroplasts 871

2. Light Reactions 873

3. Dark Reactions 896

Chapter 25 Lipid Metabolism 909

1. Lipid Digestion, Absorption, and Transport 909

2. Fatty Acid Oxidation 914

3. Ketone Bodies 928

4. Fatty Acid Biosynthesis 930

5. Regulation of Fatty Acid Metabolism 940

6. Cholesterol Metabolism 942

7. Eicosanoid Metabolism: Prostaglandins, Prostacyclins, Thromboxanes, Leukotrienes, and Lipoxins 959

8. Phospholipid and Glycolipid Metabolism 969

Chapter 26 Amino Acid Metabolism 985

1. Amino Acid Deamination 985

2. The Urea Cycle 991

3. Metabolic Breakdown of Individual Amino Acids 995

4. Amino Acids as Biosynthetic Precursors 1013

5. Amino Acid Biosynthesis 1030

6. Nitrogen Fixation 1044

Chapter 27 Energy Metabolism: Integration and Organ Specialization 1054

1. Major Pathways and Strategies of Energy Metabolism: A Summary 1054

2. Organ Specialization 1057

3. Metabolic Homeostasis: Regulation of Appetite, Energy Expenditure, and Body Weight 1061

4. Metabolic Adaptation 1065

Chapter 28 Nucleotide Metabolism 1069

1. Synthesis of Purine Ribonucleotides 1069

2. Synthesis of Pyrimidine Ribonucleotides 1076

3. Formation of Deoxyribonucleotides 1080

4. Nucleotide Degradation 1092

5. Biosynthesis of Nucleotide Coenzymes 1098

Part V Expression and Transmission of Genetic Information 1105

Chapter 29 Nucleic Acid Structures 1107

1. Double Helical Structures 1107

2. Forces Stabilizing Nucleic Acid Structures 1115

3. Supercoiled DNA 1122

Chapter 30 DNA Replication, Repair, and Recombination 1136

1. DNA Replication: An Overview 1136

2. Enzymes of Replication 1139

3. Prokaryotic Replication 1152

4. Eukaryotic Replication 1162

5. Repair of DNA 1173

6. Recombination and Mobile Genetic Elements 1184

7. DNA Methylation and Trinucleotide Repeat Expansions 1204

Chapter 31 Transcription 1216

1. The Role of RNA in Protein Synthesis 1216

2. RNA Polymerase 1221

3. Control of Transcription in Prokaryotes 1237

4. Posttranscriptional Processing 1254

Chapter 32 Translation 1285

1. The Genetic Code 1285

2. Transfer RNA and Its Aminoacylation 1292

3. Ribosomes and Polypeptide Synthesis 1309

4. Control of Eukaryotic Translation 1342

5. Posttranslational Modification 1347

6. Protein Degradation 1352

Chapter 33 Viruses: Paradigms for Cellular Function 1372

1. Tobacco Mosaic Virus 1374

2. Icosahedral Viruses 1379

3. Bacteriophage [lambda] 1390

4. Influenza Virus 1408

Chapter 34 Eukaryotic Gene Expression 1422

1. Chromosome Structure 1422

2. Genomic Organization 1432

3. Control of Expression 1446

4. Cell Differentiation and Growth 1482

Chapter 35 Molecular Physiology

1. Blood Clotting

2. Immunity

3. Motility: Muscles, Cilia, and Flagella.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

047119350X

0471417610

0471392235

OCLC:

54780033

Online:

Publisher description