Molecular biology of the neuron / [edited by R. Wayne Davies and Brian J. Morris].

Format:

Book

Contributor:

Davies, R. Wayne.

Morris, B. J. (Brian J.)

Series:

Molecular and cellular neurobiology series

Language:

English

Subjects (All):

Neurons.

Molecular biology.

Neurons--physiology.

Synaptic Transmission--physiology.

Neurotransmitter Agents--physiology.

Neuronal Plasticity--physiology.

Brain--cytology.

Medical Subjects:

Neurons--physiology.

Synaptic Transmission--physiology.

Neurotransmitter Agents--physiology.

Neuronal Plasticity--physiology.

Brain--cytology.

Physical Description:

xvii, 480 pages : illustrations ; 25 cm.

Edition:

Second edition.

Place of Publication:

Oxford ; New York : Oxford University Press, 2004.

Summary:

Nerve cells -- neurons -- are arguably the most complex of all cells. From the action of these cells comes movement, thought, and consciousness. One of the major challenges has been to find which molecules direct the various diverse aspects of neuronal function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about the molecules that control information flow in the brain or the progress of brain disease, while the expert has access to a wealth of detailed information from a wide range of topics impacting on his or her field of endeavour. The text is designed to achieve a balance of accessibility and broad coverage with up-to-date molecular detail.

In the seven years since the first edition of Molecular Biology of the Neuron there has been an explosion in the molecular information about neurons that has been discovered, and this information is incorporated into this second edition. Entirely new chapters have been introduced where recent advances have made a new aspect of neuronal function more comprehensible at the molecular level. Written by leading researchers in the field, the book provides an essential overview of the molecular structure and function of neurons, and will be an invaluable tool to students and researchers alike.

Contents:

1 Studying neuronal function using the Drosophila genetic system / J. Douglas Armstrong, Stephen F. Goodwin 1

2 Using mouse genetics to study neuronal development and function / Harald Jockusch, Thomas Schmitt-John 15

3 Gene expression: from precursor to mature neuron / Uwe Ernsberger 29

4 Protein trafficking in neurons / Christopher N. Connolly 75

5 Ion channels and electrical activity / Mauro Pessia 103

6 Molecular biology of transmitter release / Julie Staple, Stefan Catsicas 139

7 Molecular biology of postsynaptic structures / Flaminio Cattabeni, Fabrizio Gardoni, Monica Di Luca 165

8 Signal reception: Ligand-gated ion channel receptors / R. Wayne Davies, Thora A. Glencorse 183

9 Signal reception: G protein-coupled receptors / Jennifer A. Koenig 215

10 Synapse-to-nucleus calcium signalling / Giles E. Hardingham 249

11 Signalling by tyrosine phosphorylation in the nervous system / Jean-Antoine Girault 267

12 Mature neurons: Signal transduction-serine/ threonine kinases / Renata Zippel, Simona Baldassa, Emmapaola Sturani 287

13 The cytoskeleton / Javier Diaz-Nido, Jesus Avila 313

14 Neuronal Plasticity / Brian J. Morris 353

15 Genetic basis of human neuronal diseases / Mark E.S. Bailey 383

16 Ageing and the death of neurones / Paul Shiels, R. Wayne Davies 435.

Notes:

Previous ed.: Oxford: BIOS Scientific, 1997.

Includes bibliographical references and index.

ISBN:

0198509987

0198509979

OCLC:

55081950