Development of auditory and vestibular systems 3 : molecular development of the inner ear / edited by Raymond Romand and Isabel Varela-Nieto.

Format:

Book

Contributor:

Romand, R.

Varela-Nieto, Isabel.

Series:

Current topics in developmental biology ; v. 57.

Current topics in developmental biology ; v. 57

Language:

English

Subjects (All):

Auditory pathways.

Vestibular apparatus.

Developmental neurobiology.

Auditory Pathways--growth & development.

Hearing--physiology.

Vestibule--growth & development.

Medical Subjects:

Auditory Pathways--growth & development.

Hearing--physiology.

Vestibule--growth & development.

Physical Description:

xix, 490 pages, 24 unnumbered pages of plates : illustrations (some color) ; 24 cm.

Other Title:

Molecular development of the inner ear

Place of Publication:

Amsterdam ; Boston : Elsevier, [2003]

Summary:

Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research and shows how as scientists discover more genes involved in the development of the inner ear, new models can be generated to examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation.

The wide variety of experimental approaches presented in this volume will help readers follow current research in developmental inner ear biology and conceive the range of issues related to inner ear morphogenesis and concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike.

Contents:

1 Molecular Conservation and Novelties in Vertebrate Ear Development / B. Fritzsch, K. W. Beisel

II. Overview of Ideas Related to Ear Evolution 4

III. Making the Ear: Implementing and Expanding Genes for Ear Morphogenesis 6

IV. Evolution of the Ear: Molecular Origin of Mechanosensory Cells Predates Formation of the Ear 11

V. Developmental Molecular Biology of Hair Cell and Sensory Neuron Formation 13

VI. Evolution of Sensory Neurons: Heterochronic Alteration of HLH Gene Regulation 22

VII. Guidance of Afferent Fibers: The Role of Hair Cells and Other Mechanisms Revisited 23

VIII. Survival of Afferents: Evolving a Novel Mechanism and Expanding it to Fit the Increasing Complexity of Ear Development 29

IX. Splitting Hair Cell and Neuron Populations: Coevolving Sensory Epithelia and Their Innervation 33

X. Summary and Conclusions: Evolving Developmental Mechanisms 34

2 Use of Mouse Genetics for Studying Inner Ear Development / Elizabeth Quint, Karen P. Steel

I. Introduction: The Genetic Revolution 46

II. Early Morphogenesis of the Inner Ear 50

III. Development of the Neuroepithelium 55

3 Formation of the Outer and Middle Ear, Molecular Mechanisms / Moises Mallo

II. Basic Anatomical and Embryological Overview 86

III. Genetic Determinants of Outer and Middle Ear Development 89

4 Molecular Basis of Inner Ear Induction / Stephen T. Brown, Kareen Martin, Andrew K. Groves

II. Inner Ear Induction in Fish 118

III. Inner Ear Induction in Amphibians 127

IV. Inner Ear Induction in Birds 128

V. Inner Ear Induction in Mammals 131

VI. Perspectives on Inner Ear Induction 135

5 Molecular Basis of Otic Commitment and Morphogenesis: A Role for Homeodomain-Containing Transcription Factors and Signaling Molecules / Eva Bober, Silke Rinkwitz, Heike Herbrand

II. Patterning of the Inner Ear Anlagen 152

III. Transcription Factors and Diffusible Signals: A Complex Network 162

IV. Patterning and Morphogenesis 165

6 Growth Factors and Early Development of Otic Neurons: Interactions between Intrinsic and Extrinsic Signals / Berta Alsina, Fernando Giraldez, Isabel Varela-Nieto

II. Early Development of Cochlear (Auditory) and Vestibular Neurons 179

III. Extrinsic Factors in Inner Ear Neurogenesis: Fibroblast Growth Factor, Nerve Growth Factor, and Insulin-Like Growth Factor-1 Families of Growth Factors 187

7 Neurotrophic Factors during Inner Ear Development / Ulla Pirvola, Jukka Ylikoski

I. Neurotrophic Factors 208

II. The Neurotrophin System 208

III. The Glial Cell Line-Derived Neurotrophic Factor Family 217

8 FGF Signaling in Ear Development and Innervation / Tracy J. Wright, Suzanne L. Mansour

II. Fibroblast Growth Factor Signaling in Ear Development 232

9 The Roles of Retinoic Acid during Inner Ear Development / Raymond Romand

II. Metabolism of Retinoids and Their Receptors 263

III. Expression of Retinoic Acid Metabolic Enzymes and Receptors in the Developing Inner Ear 265

IV. Is Retinoic Acid Involved in Otic Placode Induction? 269

V. Retinoids as Morphogens during Early Embryogenesis 271

VI. Retinoic Acid and Patterning Genes during Inner Ear Development 278

VII. Retinoic Acid and Hair Cell Differentiation 280

10 Hair Cell Development in Higher Vertebrates / Wei-Qiang Gao

I. Morphogenesis of the Mammalian Inner Ear 294

II. Control of Hair Cell Differentiation by Specific Genes 294

III. Production and Regeneration of New Hair Cells in Mature Inner Ears 310

11 Cell Adhesion Molecules during Inner Ear and Hair Cell Development, Including Notch and Its Ligands / Matthew W. Kelley

II. Adhesion Molecules 323

III. Adhesion Molecules and Development of the Inner Ear 330

12 Genes Controlling the Development of the Zebrafish Inner Ear and Hair Cells / Bruce B. Riley

II. General Course of Zebrafish Otic Development 359

III. Otic Induction 359

IV. Patterning of the Placode and Early Vesicle 367

V. Development of Sensory Epithelia 373

VI. Auditory and Vestibular Function 378

13 Functional Development of Hair Cells / Ruth Anne Eatock, Karen M. Hurley

II. Maturation of Function 390

III. Development of Mechanoelectrical Transduction 395

IV. Developmental Acquisition of Basolateral Ion Channels 406

V. Outer Hair Cell Electromotility 425

VI. Interactions between Developing Hair Cells and Innervating Nerve Fibers 427

14 The Cell Cycle and the Development and Regeneration of Hair Cells / Allen F. Ryan

II. The Cell Cycle and the Regulation of Cell Proliferation 450

III. Hair Cell Development and Regeneration 453

IV. Cell Cycle Events during Hair Cell Development 455

V. The Cell Cycle during Hair Cell Regeneration 459.

Notes:

Includes bibliographical references and index.

ISBN:

0121531570

OCLC:

53930717