Human evolutionary genetics : origins, peoples & disease / Mark A. Jobling, Matthew Hurles, Chris Tyler-Smith.

Format:

Book

Author/Creator:

Jobling, Mark.

Contributor:

Hurles, Matthew, 1974-

Tyler-Smith, Chris

George Clapp Vaillant Book Fund.

Language:

English

Subjects (All):

Human genetics--Variation.

Human genetics.

Human evolution.

Human molecular genetics.

Evolution, Molecular.

Genome, Human.

Genetics, Medical.

Variation (Genetics).

Medical Subjects:

Evolution, Molecular.

Genome, Human.

Genetics, Medical.

Variation (Genetics).

Physical Description:

xx, 523 pages : color illustrations, maps ; 28 cm

Place of Publication:

New York ; Abingdon [England] : Garland Science, [2004]

Summary:

Human evolutionary genetics is a rapidly expanding and popular subject of the post-genomic era, and is becoming increasingly recognized as an essential part of medicine, anthropology and forensic science. It has an intuitive appeal for students and professionals alike, connected to our common desire to understand our origins. Human Evolutionary Genetics describes the molecular basis of human genetic variation and the mechanisms which give rise to it. It introduces principles behind the use of molecular genetic data to understand human evolution and population histories. It also explains how variation within human populations impacts upon the quest of modern medical genetics for genes involved in common disorders, and in different reactions to drugs. Human Evolutionary Genetics synthesizes the different aspects and presents them in a lively and authoritative way.

Contents:

Chapter 1 Why study human evolutionary genetics? 3

Section 2 How do we study genome diversity? 19

Chapter 2 Structure, function and inheritance of the human genome 21

Chapter 3 The diversity of the human genome 45

Chapter 4 Discovering and assaying genome diversity 87

Section 3 How do we interpret genetic variation? 123

Chapter 5 Processes shaping diversity 125

Chapter 6 Making inferences from diversity 153

Section 4 Where and when did humans originate? 199

Chapter 7 Humans as apes 201

Chapter 8 Origins of modern humans 235

Section 5 How did humans colonize the world? 269

Chapter 9 The distribution of diversity

out of Africa and into Asia, Australia and Europe 271

Chapter 10 Agricultural expansions 299

Chapter 11 Into new found lands 339

Chapter 12 What happens when populations meet? 373

Section 6 How is an evolutionary perspective useful? 399

Chapter 13 Understanding the past and future of phenotypic variation 401

Chapter 14 Health implications of our evolutionary heritage 439

Chapter 15 Identity and identification 473.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the George Clapp Vaillant Book Fund.

ISBN:

0815341857

OCLC:

52895882