Nanobiotechnology : concepts, applications and perspectives / edited by Christof M. Niemeyer and Chad A. Mirkin.

Format:

Book

Contributor:

Niemeyer, Christof M.

Mirkin, Chad A.

Alumni and Friends Memorial Book Fund.

Language:

English

Subjects (All):

Biotechnology.

Nanotechnology.

Physical Description:

xxii, 469 pages : illustrations (some color) ; 25 cm

Place of Publication:

Weinheim : Wiley-VCH, [2004]

Summary:

Nanotechnology is the key technology of the 21st century. The possibility to exploit the structures and processes of biomolecules for novel functional materials, biosensors, bioelectronics and medical applications has created the rapidly growing field of nanobiotechnology. Designed as a broad survey of the field, this book combines contributions from bioorganic and bioinorganic chemistry, molecular biology, materials science and bioanalytics to fathom the full scope of current and future developments. It is divided into four main sections: * Interphase Systems * Protein-based Nanostructures * DNA-based Nanostructures * Nanoanalytics Each chapter describes in detail currently available methods and contains numerous references to the primary literature, making this the perfect "field guide" for chemists, biologists and materials scientists who want to explore the fascinating world of nanobiotechnology.

Contents:

Part I Interphase Systems

1 Biocompatible Inorganic Device / Thomas Sawitowski 1

1.2 Implant Coatings 1

2 Microfluidics Meets Nano: Lab-on-a-Chip Devices and their Potential for Nanobiotechnology / Holger Bartos, Friedrich Gotz, Ralf-Peter Peters 13

3 Microcontact Printing of Proteins / Emmanuel Delamarche 31

3.2 Strategies for Printing Proteins on Surfaces 33

3.3 Microcontact Printing Polypeptides and Proteins 34

3.4 Activity of Printed Biomolecules 40

3.5 Printing Multiple Types of Proteins 42

4 Cell-Nanostructure Interactions / Joachim P. Spatz 53

5 Defined Networks of Neuronal Cells in Vitro / Andreas Offenhausser, Angela K. Vogt 66

5.2 Overview: Background and History 67

Part II Protein-based Nanostructures

6 S-Layers / Uwe B. Sleytr, Eva-Maria Egelseer, Dietmar Pum, Bernhard Schuster 77

7 Engineered Nanopores / Hagan Bayley, Orit Braha, Stephen Cheley, Li-Qun Gu 93

8 Genetic Approaches to Programmed Assembly / Stanley Brown 113

8.2 Order from Chaos 113

8.3 Monitoring Enrichment 116

8.4 Quantification of Binding and Criteria for Specificity 119

8.5 Unselected Traits and Control of Crystallization/Reactivity 119

8.6 Dominant Traits, Interpretation of Gain-of-Function Mutants 120

8.7 Interpretation and Requirement for Consensus Sequences 120

8.8 Sizes of Proteins and Peptides 122

8.9 Mix and Match, Fusion Proteins, and Context-Dependence 122

8.10 Mix and Match, Connecting Structures 122

8.11 Outlook 123

9 Microbial Nanoparticle Production / Murali Sastry, Absar Ahmad, M. Islam Khan, Rajiv Kumar 126

10 Magnetosomes: Nanoscale Magnetic Iron Minerals in Bacteria / Richard B. Frankel, Dennis A. Bazylinski 136

11 Bacteriorhodopsin and its Potential in Technical Applications / Norbert Hampp, Dieter Oesterhelt 146

11.2 Overview: The Molecular Properties of Bacteriorhodopsin 147

11.3 Overview: Technical Applications of Bacteriorhodopsin 155

12 Polymer Nanocontainers / Alexandra Graff, Samantha M. Benito, Corinne Verbert, Wolfgang Meier 168

12.3 Polymer Nanocontainers with Controlled Permeability 175

12.4 Nanoparticle Films 179

12.5 Biomaterials and Gene Therapy 180

13 Biomolecular Motors Operating in Engineered Environments / Stefan Diez, Jonne H. Helenius, Jonathon Howard 185

14 Nanoparticle-Biomaterial Hybrid Systems for Bioelectronic Devices and Circuitry / Eugenii Katz, Itamar Willner 200

14.2 Biomaterial-Nanoparticle Systems for Bioelectronic and Biosensing Applications 202

14.3 Biomaterial-based Nanocircuitry 215

Part III DNA-based Nanostructures

15 DNA-Protein Nanostructures / Christof M. Niemeyer 227

16 DNA-templated Electronics / Erez Braun, Uri Sivan 244

16.2 DNA-templated Electronics 246

16.3 Sequence-specific Molecular Lithography 249

17 Biomimetic Fabrication of DNA-based Metallic Nanowires and Networks / Michael Mertig, Wolfgang Pompe 256

17.2 Template Design 258

17.3 Metallization 262

17.4 Conductivity Measurements on Metalized DNA Wires 270

17.6 Methods 274

18 Mineralization in Nanostructured Biocompartments: Biomimetic Ferritins For High-Density Data Storage / Eric L. Mayes, Stephen Mann 278

18.2 Biomimetic Ferritins 279

18.3 High-Density Magnetic Data Storage 280

19 DNA-Gold-Nanoparticle Conjugates / C. Shad Thaxton, Chad A. Mirkin 288

19.2 The Essentials: Methods and Protocols 301

20 DNA Nanostructures for Mechanics and Computing: Nonlinear Thinking with Life's Central Molecule / Nadrian C. Seeman 308

20.3 DNA Arrays 311

20.4 DNA Nanomechanical Devices 313

20.5 DNA-based Computation 315

21 Nanoparticles as Non-Viral Transfection Agents / M. N. V. Ravi Kumar, Udo Bakowsky, Claus-Michael Lehr 319

21.1 Introduction to Gene Delivery 319

21.2 Nanoparticles for Drug and Gene Targeting 321

21.3 Nonviral Nanomaterials in Development and Testing 321

21.4 Setbacks and Strategies to Improve Specific Cell Uptake of Nonviral Systems 338

21.5 Prospects for Nonviral Nanomaterials 338

Part IV Nanoanalytics

22 Luminescent Quantum Dots for Biological Labeling / Xiaohu Gao, Shuming Nie 343

23 Nanoparticle Molecular Labels / James F. Hainfeld, Richard D. Powell, Gerhard W. Hacker 353

23.2 Immunogold-Silver Staining: A History 354

23.3 Combined Fluorescent and Gold Probes 356

23.4 Methodology 357

23.5 Applications for the Microscopical Detection of Antigens 359

23.6 Detection of Nucleic Acid Sequences 360

23.7 Applications for Microscopical Detection of Nucleic Acids 361

23.8 Technical Guidelines and Laboratory Protocols 362

23.9 Gold Derivatives of Other Biomolecules 362

23.10 Larger Covalent Particle Labels 366

23.11 Gold Targeted to His Tags 367

23.12 Enzyme Metallography 368

23.13 Gold Cluster Nanocrystals 369

23.14 Gold Cluster-Oligonucleotide Conjugates: Nanotechnology Applications 369

23.15 Other Metal Cluster Labels 372

24 Surface Biology: Analysis of Biomolecular Structure by Atomic Force Microscopy and Molecular Pulling / Emin Oroudjev, Signe Danielsen, Helen G. Hansma 387

24.2 Recent Results 388

25 Force Spectroscopy / Markus Seitz 404

26 Biofunctionalized Nanoparticles for Surface-Enhanced Raman Scattering and Surface Plasmon Resonance / Mahnaz El-Kouedi, Christine D. Keating 429

27 Bioconjugated Silica Nanoparticles for Bioanalytical Applications / Timothy J. Drake, Xiaojun Julia Zhao, Weihong Tan 444

27.2 Methods 445

27.3 Outlook 454.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

3527306587

OCLC:

53709491