Therapeutic oligonucleotides : antisense, RNAi, triple-helix, gene repair, enhancer decoys, CpG, and DNA chips / edited by Y.S. Cho-Chung, A.M. Gewirtz, and C.A. Stein.

Format:

Book

Conference/Event

Contributor:

Cho-Chung, Yoon S.

Gewirtz, A. M. (Alan M.)

Stein, Cy A.

National Institutes of Health (U.S.). Therapeutic Oligonucleotide Interest Group.

Conference Name:

NIH Symposium on Therapeutic Oligonucleotides (6th : 2002 : Warren Grant Magnuson Clinical Center)

Series:

Annals of the New York Academy of Sciences ; v. 1002.

Annals of the New York Academy of Sciences ; v. 1002

Language:

English

Subjects (All):

Oligonucleotides--Therapeutic use--Congresses.

Oligonucleotides.

Antisense nucleic acids--Therapeutic use--Congresses.

Antisense nucleic acids.

Oligonucleotides--therapeutic use.

Antisense nucleic acids--Therapeutic use.

Oligonucleotides--Therapeutic use.

Medical Subjects:

Oligonucleotides--therapeutic use.

Genre:

Conference papers and proceedings.

Physical Description:

xii, 274 pages ; 24 cm.

Place of Publication:

New York, N.Y. : New York Academy of Sciences, 2003.

Contents:

Part I Antisense: Chemistry, Sequence Specificity, and Prodrug

Conceptual "Heat-Driven" Approach to the Synthesis of DNA Oligonucleotides on Microarrays / A. Grajkowski, J. Cieslak, M.K. Chmielewski, V. Marchan, L.R. Phillips, A. Wilk, S.L. Beaucage 1

Reading, Writing, and Modulating Genetic Information with Boranophosphate Mimics of Nucleotides, DNA, and RNA / Barbara Ramsay Shaw, Mikhail Dobrikov, Xin Wang, Jing Wan, Kaizhang He, Jin-Lai Lin, Ping Li, Vladimir Rait, Zinaida A. Sergueeva, Dmitri Sergueev 12

Modulation of Toll-like Receptor 9 Responses through Synthetic Immunostimulatory Motifs of DNA / Sudhir Agrawal, Ekambar R. Kandimalla 30

Part II Interference RNA and Gene Repair

The Effect of Hydroxyurea and Trichostatin A on Targeted Nucleotide Exchange in Yeast and Mammalian Cells / Hetal Parekh-Olmedo, Julia U. Engstrom, Eric B. Kmiec 43

Short Interfering RNA (siRNA)-Mediated RNA Interference (RNAi) in Human Cells / Natasha J. Caplen, Spyro Mousses 56

RNA-Mediated Inhibition of HIV in a Gene Therapy Setting / Alessandro Michienzi, Daniela Castanotto, Nancy Lee, Shirley Li, John A. Zaia, John J. Rossi 63

Part III Antisense Delivery and Gene Therapy

Therapeutic Potentialities of EWS-Fli-1 mRNA-Targeted Vectorized Antisense Oligonucleotides / A. Maksimenko, G. Lambert, J.R. Bertrand, E. Fattal, P. Couvreur, C. Malvy 72

HER-2-Targeted Antisense Oligonucleotide Results in Sensitization of Head and Neck Cancer Cells to Chemotherapeutic Agents / Antonina S. Rait, Kathleen F. Pirollo, David Ulick, Kevin Cullen, Esther H. Chang 78

Antisense to Apoptosis Inhibitors Facilitates Chemotherapy and TRAIL-Induced Death Signaling / Uwe Zangemeister-Wittke 90

Clusterin and IGFBPs as Antisense Targets in Prostate Cancer / Martin Gleave, Burkhard Jansen 95

Part IV CpG Immune Modulators

The Therapeutic Potential of Antigen-Oligonucleotide Conjugates / Sandip K. Datta, Kenji Takabayashi, Eyal Raz 105

Regulation of CpG-Induced Immune Activation by Suppressive Oligodeoxy-nucleotides / Dennis M. Klinman, Rainald Zeuner, Hiroshi Yamada, Mayda Gursel, Debbie Currie, Ihsan Gursel 112

Part V DNA Chips, Enhancer Decoys, Triple-Helix, Imaging Gene Expression, and Morpholino Antisense

CRE-Enhancer DNA Decoy: A Tumor Target-Based Genetic Tool / Yoon S. Cho-Chung 124

Antigene Radiotherapy: Targeted Radiodamage with [superscript 125]I-Labeled Triplex-Forming Oligonucleotides / I.G. Panyutin, O.A. Sedelnikova, V.N. Karamychev, R.D. Neumann 134

Gene Targeting by Triple Helix-Forming Oligonucleotides / Alokes Majumdar, Nitin Puri, Nicholas McCollum, Sally Richards, Bernard Cuenoud, Paul Miller, Michael M. Seidman 141

Potent Inhibition of HhaI DNA Methylase by the Aglycon of 2-(1H)-Pyrimidinone Riboside (Zebularine) at the GCGC Recognition Domain / Victor E. Marquez, Ramon Eritja, James A. Kelley, Dana Vanbemmel, Judith K. Christman 154

Imaging Oncogene Expression / Xiaobing Tian, Mohan R. Aruva, Ponugoti S. Rao, Wenyi Qin, Paul Read, Edward R. Sauter, Mathew L. Thakur, Eric Wickstrom 165

Custom Cancer Therapies: Safe and Effective Treatments for Most or All Cancers / James E. Summerton 189

Part VI Antisense Targets and Combination Strategies

Antisense to the Early Growth Response-1 Gene (Egr-1) Inhibits Prostate Tumor Development in TRAMP Mice / Veronique Baron, Stephan Duss, Johng Rhim, Dan Mercola 197

Chemosensitization and Radiosensitization of Human Cancer by Antisense Anti-MDM2 Oligonucleotides: In Vitro and in Vivo Activities and Mechanisms / Hui Wang, Patsy Oliver, Zhuo Zhang, Sudhir Agrawal, Ruiwen Zhang 217

Antisense Targeting Protein Kinase A Type I as a Drug for Integrated Strategies of Cancer Therapy / Giampaolo Tortora, Fortunato Ciardiello 236

Part VII Antisense Drug Development

Applying Antisense Technology: Affinitak and Other Antisense Oligonucleotides in Clinical Development / Jon T. Holmlund 244

Clinical Studies in Patients with Solid Tumors Using a Second-Generation Antisense Oligonucleotide (GEM 231) Targeted against Protein Kinase A Type I / S. Mani, S. Goel, M. Nesterova, R.M. Martin, J.M. Grindel, M.L. Rothenberg, R. Zhang, G. Tortora, Y.S. Cho-Chung 252

Targeting Protein Kinase C-alpha (PKC-[alpha]) in Cancer with the Phosphorothioate Antisense Oligonucleotide Aprinocarsen / Michael Lahn, Karen Sundell, Stephanie Moore 263.

Notes:

Papers from the Sixth NIH Symposium on Therapeutic Oligonucleotides hosted by the NIH Therapeutic Oligonucleotides Interest Group, sponsored by the National Cancer Institute, National Institutes of Health, and held Dec. 16-17, 2002, Bethesda, MD.

Includes bibliographical references and index.

ISBN:

1573314706

1573314714

OCLC:

52937984