Immunobiology of carbohydrates / [edited by] Simon Y.C. Wong, Gemma Arsequell.

Format:

Book

Contributor:

Wong, Simon Y. C.

Arsequell, Gemma.

Series:

Molecular biology intelligence unit (Unnumbered)

Molecular biology intelligence unit

Language:

English

Subjects (All):

Carbohydrates--Immunology.

Carbohydrates.

Antigen-antibody reactions--Physiological effect.

Antigen-antibody reactions.

Carbohydrates--immunology.

Immunity, Cellular.

Receptors, Immunologic--physiology.

Medical Subjects:

Carbohydrates--immunology.

Immunity, Cellular.

Receptors, Immunologic--physiology.

Physical Description:

315 pages : illustrations ; 24 cm.

Place of Publication:

Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York : Kluwer Academic/Plenum, [2003]

Contents:

1. Carbohydrate Blood Group Antigens and Tumor Antigens / Reiji Kannagi 1

ABO(H) Blood Group Antigens 1

I and i Antigens 5

P Blood Group Antigens 9

Lewis Blood Group Antigens 12

Differentiation and Developmental Carbohydrate Determinants, Lewisx, Lewisy, Sialyl Lewisx and Related Antigens 16

Heterophile Antigens 24

2. Structural Basis for Mannose-Binding Protein Function in Innate Immunity / Russell Wallis 34

Structural Organization of MBP 35

Gene Organization of MBP 36

Sugar Recognition by MBP 37

MBP/MASP Complexes 38

Mechanism of Complement Activation by MBP 39

MBP-Associated Immunodeficiency 40

Complement Activation and Disease 41

MBP and Opsonization 42

MBP As a Therapeutic Agent 42

3. C-Reactive Protein: Structure, Synthesis and Function / Terry W. Du Clos, Carolyn Mold 46

History 46

Synthesis 47

Structure 48

Ligand Binding 48

Receptor Interactions 50

CRP and the Complement System 52

CRP and Infection 52

CRP and Autoimmunity 54

CRP and Cardiovascular Disease 55

CRP and Inflammation 56

CRP and Cytokine Production 57

4. Complement: A Major Humoral Effector System in Innate and Acquired Immunity / Philippe Gasque, B. Paul Morgan 62

Molecular Elements of the Innate Immune Response Involved in the Recognition of Pathogens and Toxic Cell Debris: A Common Ancestral Scavenging System 62

The Complement System and Complement-Associated Proteins: Routes of Activation against Pathogens 63

The C System and C-Associated Proteins: Clearance of Apoptotic Cells 65

The Proposed C1q Receptor Involved in Phagocytosis and/or Signaling Events 67

Other C1q and Defense Collagen Receptors (CR1, Cc1qr, CD91, Gc1qr) 67

C Receptors Involved in Phagocytosis and Cell Recruitment (Chemotaxis) 67

CR2(CD21): The Link Between Innate and Acquired Immune Responses 69

The Opsonic Ancestral Element 69

C and Other Innate Immune Signaling Pathways: An Ancestral Innate Immune Signaling Pathway 69

5. Carbohydrate Recognition Receptors on Antigen Presenting Cells / Philip R. Taylor, Gordon D. Brown, Luisa Martinez-Pomares, Siamon Gordon 74

The Macrophage Mannose Receptor Family 75

Other Receptors with Mannose-Specificity 78

NKCL/Dectin-2 78

[beta]-Glucan Recognition by APCs 80

Galactose Receptors 82

L-Selectin (CD62L) 82

6. Toll-Like Receptor: Specificity and Signaling / Osamu Takeuchi, Tsuneyasu Kaisho, Shizuo Akira 87

Toll-Like Receptor Family and Relatives 88

TLR Signaling Pathway 93

Essential Role of MyD88 in TLR/IL-1 Signaling 94

TLR4-Specific Signaling Pathway 95

7. C-Type Lectin and Lectin-Like Receptors in the Immune System / Sally Rogers, Simon Y. C. Wong 101

CTLDs in the Immune Response

Ligand Binding, Specificity and Function 102

Group II of CTLD-Containing Proteins in the Immune System

Endocytic Type II Transmembrane Proteins 102

Group III of CTLD-Containing Proteins in the Immune System

Pathogen Recognition 105

Group IV of CTLD-Containing Proteins in the Immune System

Leukocyte Adhesion Events 107

Group V CTLD-Containing Proteins in the Immune System

NKC Encoded Receptors 109

Ly49 Receptor Family 111

NKG2 Receptor Family 112

CD69 and NKR-P1 Receptors 113

Group VI CTLD-Containing Proteins in the Immune System

Phagocytosis and Antigen Uptake and Processing 115

8. The Sialic Acid-Binding Siglec Family / Lars Nitschke, Paul R. Crocker 119

Introduction to the Siglec Family 119

CD22: An Example of a Siglec on B Cells with Inhibitory and Adhesion Functions 124

9. Antibody Responses to Polysaccharides / Carola G. Vinuesa, Ian C.M. MacLennan 128

B Cell Activation and Signaling Pathways Triggered by Polysaccharide Antigens 129

The Three Main Sources of Antibodies 130

MZ B Cells and Their Specialized Response to Polysaccharide Antigens 138

Other TI Responses: Critical Costimulation by Toll-Like Receptors 141

10. CD1-Restricted T Cell Responses against Microbial Glycolipids / Steven A. Porcelli, Lynn G. Dover, Gurdyal S. Besra 148

CD1 Genes and the Evolution of the CD1 Family 148

CD1 Protein Structure 150

Cellular Expression and Tissue Distribution of CD1 Proteins 150

T Cell Recognition of CD1 and CD1-Presented Antigens 151

CD1-Presented Antigens 153

Cellular and Molecular Mechanisms of Antigen Presentation by CD1 162

Molecular Basis of Lipid Antigen Interactions with CD1 and TCRs 165

Potential Role of CD1 in Microbial Immunity 165

11. Processing and Presentation of Glycoproteins in the MHC Class I and II Antigen Presentation Pathways / Denise Golgher, Tim Elliott, Mark Howarth 173

Where Does Glycosylation Occur? 174

The MHC Class I Processing Pathway 174

Outline of the Class I Processing Pathway 174

How Does Glycosylation of the Protein Antigen Affect MHC Class I Processing? 174

The MHC Class II Processing Pathway 177

How Does Glycosylation Affect Class II Processing? 178

Glycopeptides As T Cell Epitopes 180

Naturally Processed Glycopeptide Epitopes 182

Crystal Structures of MHC-Glycopeptide Complexes 183

How Does the T Cell Receptor Interact with MHC-Glycopeptide Complexes? 184

Glycosylation in Autoimmune and Anti-Tumor T Cell Responses 185

12. Chemical Synthesis of Bacterial Carbohydrates / Vince Pozsgay 192

Synthesis of Bacterial Oligosaccharides 194

13. Challenges and Opportunities in the Development of New Conjugate Vaccines against Infectious Diseases / P. Moingeon, M. Moreau, A.A. Lindberg 274

The Success of Vaccines Based on Glycoconjugates 274

Conjugate Vaccines in Development 277

New Directions 279

Specific Challenges in the Development of Conjugate Vaccines 282

14. Carbohydrate-Based Targets and Vehicles for Cancer and Infectious Diseases Vaccines / Vasso Apostolopoulos, Magdalena Plebanski, Ian McKenzie 292

Bacterial Carbohydrates As Danger Signals 292

Bacterial Carbohydrates As Human Vaccines 293

Bacterial Carbohydrates As the Basis of Novel Vaccine Approaches 294

Parasite Carbohydrates As Targets of Protective Immunity 294

Parasite Carbohydrates As Immunomodulators 295

Targeting the Mannose Receptor for Vaccine Development 296

Targeting the Mannose Receptor for Drug Therapy 296

Targeting the Mannose Receptor for Antigen Delivery 297

Targeting the Scavenger Receptor for Vaccine Development 298

Future Prospects 298

15. The Interaction between Anti-Gal and the [alpha]-Gal Epitope As an Immunologic Barrier to Xenotransplantation / Uri Galili 302

Elimination of [alpha]-Gal Epitopes 307

Prevention of Anti-Gal Response in Xenograft Recipients 308.

Notes:

Includes bibliographical references and index.

ISBN:

0306478447

OCLC:

52930175