Intracellular pathogens in membrane interactions and vacuole biogenesis / [edited by] Jean-Pierre Gorvel.

Format:

Book

Contributor:

Gorvel, Jean-Pierre.

Series:

Molecular biology intelligence unit (Unnumbered)

Molecular biology intelligence unit

Language:

English

Subjects (All):

Endocytosis.

Host-bacteria relationships.

Cytoplasmic Vesicles--immunology.

Immunity, Innate--physiology.

Bacterial Infections--physiopathology.

Bacterial Proteins--immunology.

Cell Membrane Structures--immunology.

Membrane Transport Proteins--immunology.

Medical Subjects:

Cytoplasmic Vesicles--immunology.

Immunity, Innate--physiology.

Bacterial Infections--physiopathology.

Bacterial Proteins--immunology.

Cell Membrane Structures--immunology.

Membrane Transport Proteins--immunology.

Physical Description:

301 pages : illustrations ; 24 cm.

Place of Publication:

Georgetown, Tex. : Landes Bioscience/Eurekah.com ; New York : Kluwer Academic/Plenum, [2004]

Contents:

1. Membrane Traffic in the Endocytic Pathway / Jean-Michel Escola, Jean Gruenberg 1

Membrane Trafficking in Eukaryotic Cells 1

Ways of Entry into the Cell 1

The Endocytic Pathway 3

Coat Components 5

SNAREs and Rab Proteins 7

Lipids and Protein-Lipid Microdomains 8

2. Lysosomes / Steve Caplan, Juan S. Bonifacino 16

Function and Composition 16

Morphology 16

Pathways to the Lysosome 18

Models for the Biogenesis of Lysosomes 28

Human Diseases Involving Lysosomes 30

3. Lipid Rafts and Host Cell-Pathogen Interactions / Lorena Perrone, Chiara Zurzolo 34

Rafts Organization 34

Rafts, Caveolae and Caveolae-Like Structures 35

Rafts Detection 35

Rafts Functions 36

Rafts and Pathogens 40

4. Endosome-Phagosome Interactions in Pathogenesis / Carmen Alvarez-Dominguez, Carla Pena-Macarro, Amaya Prada-Delgado 51

Factors Involved in Phagosome-Endosome/Lysosome Fusion 51

Pathogen Interference with Trafficking and Immune Response 54

Cytokines and Phagosome-Endosome/Lysosome Interactions 60

Future Applications 61

5. Macrophages: Agents of Immunological Surveillance or Targets for Pathogens? / Rosangela P. da Silva, Sigrid Heinsbroek, Bongi Ntolosi, Siamon Gordon 65

Macrophage Phagocytic Receptors 66

Non-Opsonic Receptors 72

6. Intestinal Epithelial Cells: A Route of Entry for Entero-Invasive Pathogens / Philippe J. Sansonetti, Guy Tran Van Nhieu 85

Functional Anatomy of the Intestinal Epithelial Barrier 85

Categories of Pathogens with Regard to Their Interaction with the Intestinal Epithelial Barrier 86

Cellular Routes of Invasion by Enteric Pathogens (M Cells vs. Villous Epithelial Cells vs. CD18-Mediated Pathways) 86

Molecular and Cellular Mechanisms of Epithelial Cell Invasion 91

7. Life and Death of Brucella within Cells / Edgardo Moreno, Javier Pizarro-Cerda 99

Brucella Is Translocated by M Cells 99

Brucella Binds and Penetrates Host Cells 99

Survival within Polymorphonuclear Neutrophils 103

Life within Non-Professional Phagocytes 103

Life Cycle within Macrophages 106

Cellular Functions during Infection 108

Brucella Virulence Mechanisms 108

Control of the Intracellular Infection 117

8. Biogenesis of Salmonella-Containing Vacuoles in Eukaryotic Cells / Olivia Steele-Mortimer, Stephane Meresse 130

Life in a Vacuole 130

Virulence Factors 130

The Intracellular Environment 131

Bacterial Effectors Involved in SCV Biogenesis 134

9. Evasion of Phagosome Lysosome Fusion and Establishment of a Replicative Organelle by the Intracellular Pathogen Legionella pneumophila / Craig R. Roy, Jonathan C. Kagan 142

The L. pneumophila dot/icm Genes Encode a Type IVB Transporter Required for Host Cell Pathogenesis 143

The Dot/Icm Transporter Plays an Essential Role in Biogenesis of a Replicative Organelle 144

Distinct Virulence Traits Are Regulated by Different Icm Proteins 147

The Dot/Icm Transporter Does More than Just Inhibit Maturation of Phagosomes Containing L. pneumophila 148

Subversion of ER Vesicle Trafficking by L. pneumophila Creates a Stable Organelle that Supports Intracellular Growth 148

10. Phagosome Biogenesis in Relation to Intracellular Survival Mechanisms of Mycobacteria / Lutz Thilo, Chantal de Chastellier 153

Intracellular Survival 153

Early Intervention by Mycobacteria Is Required to Prevent Phagosome Maturation 155

11. Molecular Mechanisms Regulating Membrane Traffic in Macrophages: Lessons from the Intracellular Pathogen Mycobacterium spp. / Jean Pieters 170

The Endocytic Pathway 170

The Phagosomal Pathway 171

The Model System: Interaction of Pathogenic Mycobacteria with Macrophages 172

Point of Entry: Crucial Role for Plasma Membrane Cholesterol 173

Survival Inside the Macrophage: How to Avoid Lysosomal Delivery 173

Role of the Coat Protein TACO for Mycobacterial Survival 175

12. Chlamydia / Isabelle Jutras, Agathe Subtil, Benjamin Wyplosz, Alice Dautry-Varsat 179

Chlamydia Entry 181

Maturation of the Chlamydial Inclusion 183

13. Host Cell Signaling Induced by the Pathogenic Neisseria Species / Andreas Popp, Oliver Billker, Thomas F. Meyer 190

Infection of Mucosal Surfaces by Pathogenic Neisseria Species 190

Establishing Attachment via Type IV Pili 191

The Role of Opa Proteins in the Interaction with Host Cells 194

PorB Influence on Host Cell Functions 197

Stress Response Signaling in Epithelial and Endothelial Cells 198

14. Against Gram-Negative Bacteria: The Lipopolysaccharide Case / Ignacio Moriyon 204

LPS Structure, Role in the Outer Membrane (OM) and MP 204

LPS and the Innate Immune System 207

The LPS of Facultative Intracellular Pathogens 214

Sensitivity to Antimicrobial Peptides and Proteins 218

15. Immune Recognition of the Mycobacterial Cell Wall / Steven A. Porcelli, Gurdyal S. Besra 231

Overview of the Mycobacterial Cell Wall Structure 231

Mycobacterial Peptidoglycans and Muramyl Dipeptide 233

Mycolic Acids and Glycosylated Mycolates 234

Lipoarabinomannan and Other Mycobacterial Lipoglycans 237

Other Potentially Immunoreactive Mycobacterial Cell Wall Lipids 240

Cell Wall Associated Proteins of Mycobacteria 242

16. Antigen Presentation by MHC Class II Molecules / Tone F. Gregers, Tommy W. Nordeng, Oddmund Bakke 251

Assembly and Initial Transport of MHC Class II and Invariant Chain 251

Class II Molecules in the Endocytic Pathway 256

Processing Events in the Endocytic Compartment 260

Ii May Regulate Antigen Processing 262

Accessory Molecules in MHC Class Peptide Loading 262

Cells Surface Expression of Class II Molecules 264

Antigen Presentation on Recycling MHC Class II Molecules 265

17. Bacteria-Induced Innate Immune Responses at Epithelial Linings / Fredrik Backhed, Agneta Richter-Dahlfors 279

Why Don't Insects Die from Infections? 279

Adaptive versus Innate Immune Systems 280

Mucosal, Epithelial Surfaces Constitute an Active and Efficient Barrier to the Outside World of Microbes 281

Different Mechanisms for Bacterial Recognition at Epithelial Linings 281

The Repertoire of Pattern Recognition Receptors Expressed on Epithelial Cells Determines Responsiveness towards Bacteria 281

Bacterial Attachment to Epithelial Cells Induces Innate Immune Responses 283

The Bacterially Secreted Toxin [alpha]-Hemolysin Induces Innate Responses via Induction of Intracellular Ca[superscript 2+] Oscillations in Epithelial Cells 284

Indirect Effector Molecules in Innate Immunity

Cytokines 284

Direct Effector Molecules in Innate Immunity

Antimicrobial Peptides 284

Functional Coupling of the Adaptive and the Innate Immune System 285

Bacteria Can Thwart the Innate Immune System by a Variety of Mechanisms 285

18. Pathogens and Hosts: Who Wins? / Jonathan C. Howard 290.

Notes:

Includes bibliographical references and index.

ISBN:

0306478331

OCLC:

52377480