Textbook of biological psychiatry / edited by Jaak Panksepp.

Format:

Book

Contributor:

Panksepp, Jaak, 1943-2017.

Language:

English

Subjects (All):

Biological psychiatry.

Biological Psychiatry.

Medical Subjects:

Biological Psychiatry.

Physical Description:

xxiii, 699 pages : illustrations ; 26 cm

Place of Publication:

Hoboken, N.J. : Wiley-Liss, [2004]

Summary:

Not until the publication of the Textbook of Biological Psychiatry has the science of psychiatric disorders and clinical practice been seamlessly integrated in a modern text. In this landmark volume, editor Jaak Panksepp assembles the perspectives of top scientists and clinicians who apply contemporary neuroscience to psychiatric issues. In each chapter, the book draws on a range of cutting-edge research areas -- such as the biochemistry of neurotransmission, behavioral pharmacology, and the clinical aspects of psychiatric problems -- to give you the most informed, practical overview of biological psychiatry available. Featuring a cohesive, three-part organization, the Textbook of Biological Psychiatry begins with an incisive look at core concepts, from the role of stress, sleep, and sexuality in psychiatric disorders to the use of neuroimaging in psychiatry. The Textbook then considers the biological mechanisms and treatment of those disorders that pose major psychiatric challenges. Just as it distinguishes itself through a one-of-a-kind clinical approach to psychiatry, the Textbook of Biological Psychiatry also offers a unique outlook on the future of the field. Compiled here are the latest, forward-thinking insights in the treatment of anxiety and mood disorders, somatic treatments, sociophysiology, and more. Taken together, the Textbook of Biological Psychiatry is more than the only new psychopharmacology reference that integrates the study of the human mind and brain with psychiatric clinical practice. It is an essential, accessible collection of insights from the field's preeminent researchers -- one that covers the full are of the discipline: past, present, and future.

Contents:

1 Biological Psychiatry Sketched

Past, Present, and Future / Jaak Panksepp 3

Historical Overview 5

Three Giants of the First Half of the 20th Century 7

Three Great Phases of 20th-Century American Psychiatry 9

About 1910-1940: The Meyerian Synthesis of a Holistic Psychobiology 9

World War II through the 1970s: The Psychoanalytic Era 10

Ultrapositivistic Psychopharmacology Era (1970-Present) 12

Dilemma of Psychiatric Diagnostics: DSMs and Beyond 17

Functions of Diagnostics 19

From Pathophysiology to Pathogenesis 20

Perennial Problem: Distinguishing Affective and Cognitive Processes 24

Coda: Intersection of 20th-Century Forces Leading to a 21st-Century Synthesis 28

2 Imaging Human Emotions and Affective Feelings: Implications for Biological Psychiatry / Mario Liotti, Jaak Panksepp 33

On the Nature of Emotions 33

Emotional Changes Following Brain Damage 36

Neuroimaging Studies of Emotion 39

Brain Changes as a Function of Emotional States 44

Reciprocity of Human Cortico-Limbic Activity 50

Basic Emotional Operating Systems of the Brain: Animal Studies 51

Generating Emotional Feelings through Upper Brainstem-Limbic and Cortical Interactions 59

Conclusions and Some Psychiatric Implications 65

3 Neural Substrates of Consciousness: Implications for Clinical Psychiatry / Douglas F. Watt, David I. Pincus 75

Dualism versus Emergent Properties 77

Nosology: Core versus Extended Consciousness 78

Classical Work on the Neural Substrates of Consciousness 79

Recent Work on the Neural Substrates of Consciousness: Brief Overview of Anatomical, Connectivity, Neuromodulatory, and Neurodynamic Aspects 80

Case Study 1: Delirium

A Common Disorder of Attentional Function and Working Memory 84

Neuroanatomical Systems and Consciousness

Basic Lesion/Functional Correlates 88

Thalamic Systems 92

Cortical Systems 94

Two Case Studies of Mesodiencephalic Lesions 98

Neurodynamic Aspects of Consciousness 102

Summary Heuristics/Questions for Future Research 105

4 Stress, Sleep, and Sexuality in Psychiatric Disorders / Terrence Deak, Jaak Panksepp 111

Theoretical Framework for Understanding Stress Responsive Systems 112

Diathesis-Stress Models 114

Stress Responsive Systems 115

Integrative Role for Brain Cytokines 122

Sexuality and the Passions of the Brain 124

Sleep, Stress and the Restoration of Brain and Mind 130

5 Psychobiology of Personality Disorders / Brian Knutson, Andreas Heinz 145

What Is Personality? 150

How Are Personality Disorders And Personality Related? 152

What Leads to "Disordered Personality"? 153

How Can "Disordered Personality" Be Treated? 157

Postscript: A View to the Future 159

6 Functional Neuroimaging in Psychiatry / Johannes Tauscher, Nikolas Klein, Shitij Kapur 167

Magnetic Resonance Imaging 168

PET and SPECT 169

Studies of Cerebral Metabolism and Blood Flow 171

Neurotransmitter Imaging Studies 177

Future Directions and Challenges 186

Part II Core Psychiatric Challenges 195

7 Depression: A Neuropsychiatric Perspective / Helen S. Mayberg 197

Diagnostic and Clinical Features 197

Treatment Options 201

Syndromal Markers 203

Biochemical Markers 206

Animal Models 208

Regional Brain Markers 208

8 Treatment of Mood Disorders / Pedro L. Delgado, Paul Zarkowski 231

Classification 232

General Treatment Principles 235

Antidepressants 239

Somatic Treatments for Major Depression 250

Antimanic and Mood Stabilizers 252

9 Neuroscience of Schizophrenia / Christine Pesold, Rosalinda C. Roberts, Brian Krikpatrick 267

Diagnosis and Classification of Schizophrenia 268

Etiology 270

Environmental Risks 274

Course of Illness 276

Neuropathological Abnormalities 277

Neurocognitive Problems 285

Neuropsychiatric Syndromes 287

Neurochemical Abnormalities 287

Animal Models 289

10 Pharmacological Treatment of Schizophrenia / Rajiv Tandon, Michael D. Jibson 299

Targets of Pharmacological Treatment 300

Course of Treatment 306

Combining Several Medications 309

Future Trends 311

11 Psychobiology of Posttraumatic Stress Disorder / Bessel A. van der Kolk 319

Psychophysiological Effects of Trauma 325

Lessons from Neuroimaging 330

Implications for Treatment 335

12 Nature and Treatment of Panic Disorder / Fredric N. Busch, Barbara L. Milrod 345

Course of Panic Disorder 347

Basic Models of the Etiology of Panic Disorder 348

Treatment of Panic Disorder 354

Long-Term Outcome of Treatment Trials for Panic Disorder 359

13 Nature and Treatment of Obsessive-Compulsive Disorder / Lisa A. Snider, Susan E. Swedo 367

Epidemiology 368

Clinical Presentation 370

Comorbidity 372

The OCD Spectrum 373

Neurobiology 375

Treatment 382

14 Biological Basis of Childhood Neuropsychiatric Disorders / Bradley S. Peterson, Jaak Panksepp 393

Pervasive Developmental Disorders and Specific Genetic Syndromes 394

Childhood-Onset Schizophrenia 408

Disorders of Impulse Control 409

15 Aging and Dementia / Mark T. Wright, A. John McSweeny, Amy Kieswetter 437

History 437

Cognition and Memory in Normal Aging 439

Mild Cognitive Impairment 443

Diagnosis of Dementia 450

Some Major Causes of the Syndrome of Dementia 451

Alzheimer's Disease 452

Frontotemporal Dementia 461

Vascular Dementia 467

Dementia with Lewy Bodies 471

Part III Future Prospects 487

16 Emerging Neuroscience of Fear and Anxiety: Therapeutic Practice and Clinical Implications / Jaak Panksepp 489

Subcortical FEAR System of the Mammalian Brain: The "Royal Road" to Understanding the Nature of Angst 492

Treatment of Anxiety in Clinical Practice 499

Dispersion and Functions of Fear Systems in the Brain: Continuing Studies of the Neuroanatomy of FEAR 505

Experiential-Affective Attributes of Fear and Anxiety 506

17 Somatic Treatments in Psychiatry / Ziad Nahas, Jeffrey P. Lorberbaum, Frank A. Kozel, Mark S. George 521

Electroconvulsive Therapy 522

Magnetic Seizure Therapy 525

Transcranial Magnetic Stimulation 526

Vagus Nerve Stimulation 532

Deep Brain Stimulation 536

Psychiatric Neurosurgery 537

Future Directions 539

18 Psychoanalysis and Psychopharmacology: Art and Science of Combining Paradigms / Marcia Kaplan 549

Definition of Psychoanalytic Concepts 550

Challenge of Combining Paradigms 552

Future Prospects 566

19 Depth Psychological Consequences of Brain Damage / Oliver H. Turnbull, Mark Solms 571

Depth Neuropsychology and Issues of Methodology 573

Prevalence of Psychological Changes in Neurological Patients 575

Lesions to the Left Convexity 576

Ventromesial Frontal Lobes 579

Confabulation and the Neurobiology of Emotion Systems 582

Lesions to the Right Convexity 585

20 Sociophysiology and Evolutionary Aspects of Psychiatry / Russell Gardner, Jr., Daniel R. Wilson 597

Relevant Evolutionary Concepts 598

Sociobiological Factors of Ultimate Causation 604

Psychiatric Pathogenesis as Communicational Disorder 607

Research on Substance Abuse and Social Rank Hierarchy 613

Preliminary Treatment Implications 618

21 Future of Neuropeptides in Biological Psychiatry and Emotional Psychopharmacology: Goals and Strategies / Jaak Panksepp, Jaanus Harro 627

Neuropeptide Medicines: Still Waiting in the Wings 630

Emotional Foundations of Psychiatric Disorders 632

Neuropeptides in Psychiatric Disorders 634

Affective Foundations of Psychiatric Disorders and the Neurochemical Coding of Emotions 636

Two Childhood Disorders: Debatable Examples of Neuropeptide and Neurobehavioral Approaches 645

Neurotrophins and Psychiatric Disorders 647

Appendix A Pharmacodynamics and Pharmacokinetics / Jaanus Harro 661

Pharmacodynamics: What Can the Drug Do to the Body? 662

Pharmacokinetics: What Can Happen to a Drug in the Body? 670

Drug interactions, Tolerance, and Dependence 678.

Notes:

Includes bibliographical references and index.

ISBN:

0471434787

OCLC:

51924183

Online:

Publisher description