Stem cell transplantation for hematologic malignancies / edited by Robert J. Soiffer.

Format:

Book

Contributor:

Soiffer, Robert J.

Series:

Contemporary hematology

Language:

English

Subjects (All):

Hematopoietic stem cells--Transplantation.

Hematopoietic stem cells.

Lymphomas--Treatment.

Lymphomas.

Multiple myeloma--Treatment.

Multiple myeloma.

Leukemia--Treatment.

Leukemia.

Leukemia--therapy.

Hematopoietic Stem Cell Transplantation.

Lymphoma--therapy.

Medical Subjects:

Leukemia--therapy.

Hematopoietic Stem Cell Transplantation.

Lymphoma--therapy.

Physical Description:

x, 486 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2004]

Summary:

Over the past several years, fundamental notions about transplantation have changed to such a degree that even the once familiar term, bone marrow transplant, is becoming increasingly outdated. In Stem Cell Transplantation for Hematologic Malignancies, leading investigators and physicians/clinicians comprehensively survey the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic graft-vs-host disease (VGHD), delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation. Also discussed are the role of donor lymphocyte infusions in the treatment and prevention of relapse after stem cell transplantation and their influence on the development of nonmyeloablative transplantation. Comprehensive and state-of-the-art, Stem Cell Transplantation for Hematologic Malignancies outlines the many exciting advances that are working toward realization today while fully explaining the process of stem cell transplantation for malignant disease.

Contents:

Part I. Transplant for Malignant Disease

1 Allogeneic and Autologous Stem Cell Transplantation for Acute Leukemia and Myelodysplasia in the Adult / Sandra Cohen, Stephen J. Forman 3

2 Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia / Humberto Caldera, Sergio Giralt 25

3 Stem Cell Transplantation for Hodgkin's and Non-Hodgkin's Lymphomas / Thomas J. Kenney, John W. Sweetenham 47

4 Autologous and Allogeneic Transplantation for Multiple Myeloma / Faith E. Davies, Kenneth C. Anderson 85

5 Hematopoietic Progenitor Cell Transplantation for Breast Cancer / Yago Nieto, Elizabeth J. Shpall 99

Part II. Complications of Transplantation

6 Pathophysiology of Acute Graft-vs-Host Disease / Takanori Teshima, James L. M. Ferrara 135

7 Acute Graft-vs-Host Disease / Uwe Platzbecker, H. Joachim Deeg 159

8 Chronic Graft-vs-Host Disease After Transplantation / Georgia B. Vogelsang, Colleen H. McDonough 185

9 Immune Reconstitution After Allogeneic Transplantation / Carolyn A. Keever-Taylor 201

10 Infection in the Hematopoietic Stem Cell Transplant Recipient / Lindsey Baden, Robert H. Rubin 237

11 EBV Lymphoproliferative Disease After Transplantation / Stephen Gottschalk, Cliona M. Rooney, Helen E. Heslop 259

12 Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation / Kenneth R. Cooke 271

13 Hepatic Veno-Occlusive Disease / Paul G. Richardson 297

14 Quality-of-Life Issues Posttransplantation / Stephanie J. Lee 315

Part III. Sources of Donor Stem Cells

15 Stem Cell Sources: Peripheral Blood Stem Cells and Bone Marrow for Allogeneic Transplantation / Corey Cutler, Joseph H. Antin 337

16 Allogeneic Unrelated Donor Blood and Marrow Transplantation / Daniel Weisdorf 357

17 Haploidentical Stem Cell Transplantation / P. Jean Henslee-Downey 373

18 Umbilical Cord Hematopoietic Stem Cell Transplantation / Timothy F. Goggins, Nelson J. Chao 391

Part IV. Graft Engineering

19 Tumor Contamination of Stem Cell Products: The Role of Purging / John G. Gribben 417

20 T-Cell Depletion to Prevent Graft-vs-Host Disease / Vincent Ho, Robert J. Soiffer 431

Part V. Graft-Vs-Tumor Effect

21 Donor Lymphocyte Infusions: Clinical Applications and the Graft-vs-Leukemia Effect / Edwin P. Alyea III 453

22 Nonmyeloablative Transplantation / Lyle C. Feinstein, Brenda M. Sandmaier 469.

Notes:

Includes bibliographical references and index.

ISBN:

1588291804

OCLC:

52471418