Genes, development and cancer : the life and work of Edward B. Lewis / edited with commentary by Howard D. Lipshitz.

Format:

Book

Author/Creator:

Lewis, Edward B., 1918-2004.

Contributor:

Lipshitz, Howard D.

Rosengarten Family Fund.

Language:

English

Subjects (All):

Lewis, Edward B., 1918-2004--Awards.

Lewis, Edward B.

Lewis, Edward B., 1918-2004.

Nobel Prizes.

Geneticists--United States--Biography.

Geneticists.

Genes--Miscellanea.

Genes.

Developmental genetics--Miscellanea.

Developmental genetics.

Radiation carcinogenesis--Genetic aspects--Miscellanea.

Radiation carcinogenesis.

Radiation carcinogenesis--Genetic aspects.

Awards.

United States.

Genre:

Trivia and miscellanea.

Biographies.

Physical Description:

xvi, 557 pages : illustrations (some color) ; 25 cm

Place of Publication:

Boston : Kluwer Academic Publishers, [2004]

Contents:

Section I Genes: Lewis and the Nature of the Gene 13

Invention of the cis-trans test for position effects 14

Position pseudoalleles 16

The bithorax pseudoalleles and the concept of developmental control 18

Gene evolution by tandem duplication 21

From cisvection to transvection 22

Extending the bithorax pseudoalleleic series 23

Genetic versus functional models 25

From genes to gene complexes 26

Star-recessive, a spontaneous mutation in Drosophila melanogaster. Proceedings of the Minnesota Academy of Science 7:23-26 (1939) / E. B. Lewis 31

Another case of unequal crossing over in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 27:31-34 (1941) / E. B. Lewis 35

The relation of repeats to position effect in Drosophila melanogaster. Genetics, 30:137-166 (1945) / E. B. Lewis 39

The pseudoallelism of white and apricot in Drosophila melanogaster. Proceedings of the National Academy of Sciences USA 38:953-961 (1952) / E. B. Lewis 69

Pseudoallelism and gene evolution. Cold Spring Harbor Symposia on Quantitative Biology, 16:159-174 (1951) / E. B. Lewis 77

The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. American Naturalist 88:225-239. (1954) / E. B. Lewis 99

Some aspects of position pseudoallelism. American Naturalist 89:73-89 (1955) / E. B. Lewis 113

Genes and gene complexes. Heritage from Mendel, pp. 17-47. Edited by R. A. Brink. University of Wisconsin Press, Madison, Wisconsin. (1967) / E. B. Lewis 129

Section II Genes and Development: Lewis and the Genetic Control of Development 157

Developmental genetics 157

Gain-of-function and loss-of-function bithorax alleles, and the operon model 159

Genetic mosaics: spatial and temporal aspects of bithorax function 162

The 1978 paper: A paradigm for the genetic control of development 163

Trans-acting regulators: positive and negative control of the homeotic complexes 168

Cis-regulation within the BX-C: the rules of engagement 169

Genes and developmental pathways. American Zoologist, 3:33-56 (1963) / E. B. Lewis 175

A gene complex controlling segmentation in Drosophila. Nature, 276:565-570 (1978) / E. B. Lewis 205

Genetic control of body segment differentiation in Drosophila. In: Developmental Order: Its Origin and Regulation. 40th Annual Symposium of the Society for Developmental Biology, Boulder, Colorado, June 1981. Edited by S. Subtelny and P. B. Green. Alan R. Liss, Inc., New York, 1982, pp. 533-554. (1982) / Ian Duncan, E. B. Lewis 219

Control of body segment differentiation in Drosophila by the bithorax gene complex. In: Embryonic Development, Part A: Genetic Aspects. Edited by M. M. Burger and R. Weber. Alan R. Liss, New York., pp. 269-288 (1982) / E. B. Lewis 239

Regulation of the genes of the bithorax complex in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 50:155-164 (1985) / E. B. Lewis 255

Section III Molecules and Development: Lewis and the Molecular Control of Development 275

Positional cloning of the BX-C 275

Completing the bithorax mutant series 277

The molecular basis of developmental control 278

Bithorax and the evolution of sexually dimorphic traits 281

DNA sequence motifs in the cis-regulatory regions of the BX-C 283

Evolution of the HOX complexes 285

Molecular genetics of the bithorax complex in Drosophila melanogaster. Science, 221:23-29 (1983) / W. Bender, M. Akam, F. Karch, P. A. Beachy, M. Peifer, P. Spierer, E. B. Lewis, D. S. Hogness 287

The abdominal region of the bithorax complex. Cell, 43:81-96 (1985) / F. Karch, B. Weiffenbach, M. Peifer, W. Bender, I. Duncan, S. Celniker, M. Crosby, E. B. Lewis 303

Transabdominal, a dominant mutant of the bithorax complex, produces sexually dimorphic segmental transformation of Drosophila. Genes and Development, 1:111-123 (1987) / S. E. Celniker, E. B. Lewis 333

Molecular basis of Transabdominal

a novel sexually dimorphic mutant of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 90:1566-1570 (1993) / S. E. Celniker, E. B. Lewis 357

Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA 92:8403-8407 (1995) / E. B. Lewis, J. D. Knafels, D. R. Mathog, S. E. Celniker 367

Splits in fruitfuly Hox gene complexes. Nature, 380:116 (1966) / G. Von Allmen, I. Hogga, A. Spierer, F. Karch, W. Bender, H. Gyurkovics, E. B. Lewis 377

Evolution of the homeobox complex in the Diptera. Current Biology, 13:R587-R588 (2003) / E. B. Lewis, B. Pfeiffer, D. R. Mathog, S. E. Celniker 381

Section IV Radiation and Cancer: Lewis and the Somatic Effects of Ionizing Radiation 389

Genetic and somatic effects of ionizing radiation 389

The political and social context 390

Leukemia and ionizing radiation 392

Political fallout 395

Thyroid radiation doses from weapons fallout 400

Best estimates of risk: leukemia in populations exposed to low doses of radiation 401

Estimates of lung cancer risk: the Batelle Beagles 403

Leukemia and ionizing radiation. Science, 125:965-972 (1957) / E. B. Lewis 405

Thyroid radiation doses from fallout. Proceedings of the National Academy of Sciences 45:894-897 (1959) / E. B. Lewis 425

Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science, 142:1492-1494 (1963) / E. B. Lewis 429

Ionizing radiation and tumor production. In: Genetic Concepts and Neoplasia, Williams and Wilkins Co, pp. 57-73 (1970) / E. B. Lewis 437

Letters: Leukemia, radiation, and hyperthyroidism. Science, 174:454 (1971) / E. B. Lewis 451

Analysis of lung tumor mortality in the Batelle Beagle Lifespan experiment. In: Health Effects of Alpha-Emitting Particles in the Respiratory Tract, Report of Ad Hoc Committee on "Hot Particles" of the Advisory Committee on the Biological Effects of Ionizing Radiations, National Academy of Sciences-National Research Council. Publ. EPA 520/4-76-013, U.S. Environmental Protection Agency, Washington, DC (1976) / E. B. Lewis 453

Ionizing radiation, cancer induction and radioactive fallout. In: Proceedings of the International Conference. The Discovery of Polonium and Radium

its scientific and philosophical consequences, benefits and threats to mankind. Polish Academy of Sciences, Warsaw, Poland, pp. 227-237 (1998) / E. B. Lewis 465

Section V Historical Perspectives

Homeosis: the first 100 years. Trends in Genetics, 10:341-343 (1994) / E. B. Lewis 475

Remembering Sturtevant. Genetics, 141:1227-1230 (1995) / E. B. Lewis 481

C. B. Bridges' repeat hypothesis and the nature of the gene. Genetics: in press (2003) / E. B. Lewis 487

Autobiographical sketch (unpub) / E. B. Lewis 497

The bithorax complex: the first fifty years. Les Prix Nobel, 1995. Almquist & Wiksell International: Stockholm, Sweden, pp. 233-260 (1996) / E. B. Lewis 503.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

ISBN:

140207591X

OCLC:

53099073