Mathematical modeling in nutrition and the health sciences / edited by Janet A. Novotny, Michael H. Green, and Ray C. Boston.

Format:

Book

Conference/Event

Contributor:

Novotny, Janet A. (Janet Anne), 1964-

Green, Michael H.

Boston, Ray C.

Conference Name:

Conference on Mathematical Modeling in Nutrition and the Health Sciences (7th : 2000 : Pennsylvania State University)

Series:

Advances in experimental medicine and biology ; v. 537.

Advances in experimental medicine and biology ; v. 537

Language:

English

Subjects (All):

Nutrition--Mathematical models--Congresses.

Nutrition.

Medical sciences--Mathematical models--Congresses.

Medical sciences.

Mathematical models.

Nutrition--Mathematical models.

Models, Theoretical.

Medical Subjects:

Nutrition.

Models, Theoretical.

Genre:

Conference papers and proceedings.

Physical Description:

xxiv, 420 pages : illustrations ; 26 cm.

Place of Publication:

New York : Kluwer Academic/Plenum Publishers, [2003]

Summary:

This volume is the proceedings of the 7th Mathematical Modeling in Experimental Nutrition Conference held at Penn State University July 29 until August 1, 2000. The book addresses the determination of optimal intakes of nutrients and food components to provide lifelong health and reduce incidence of disease. Mathematical modelling provides a means of rigorously defining the functions of a system and using a variety of conditions to stimulate responses. This volume presents the newest advances in modelling and related experimental techniques required to meet the new challenges currently facing nutrition and biological science.

Contents:

Historical Perspectives and Future Directions

The Minimal Model of Glucose Regulation: A Biography / Richard N. Bergman 1

Cornerstones to Shape Modeling for the 21st Century: Introducing the Aka-Glucose Project / Raymond C. Boston, Darko Stefanovski, Peter Moate, Oscar Linares, Peter Greif 21

Development and Use of Mathematical Models

Aspects of Effective Modeling / Judah Rosenblatt 43

Fitting a Mathematical Model to Biological Data: Intracellular Trafficking in Niemann-Pick C Disease / Meryl E. Wastney, Peter G. Pentchev, Edward B. Neufeld 63

A Saturation Kinetic Model to Teach Balance of Essential Fatty Acids in Nutrition Education / James L. Hargrove, Jinah Hwang, Diane K. Hartle 77

Theoretical Modeling Issues

Modeling Processes from Probabilities / James H. Matis, Thomas R. Kiffe 87

Understanding the Relationship Between Carcinogen-Induced Dna Adduct Levels in Distal and Proximal Regions of the Colon / Jeffrey S. Morris, Naisyin Wang, Joanne R. Lupton, Robert S. Chapkin, Nancy D. Turner, Mee Young Hong, Raymond J. Carroll 105

Experimental Aspects of Kinetic Data

Methodological Issues in Stable Isotope- Based Kinetic Studies in Children / Ian J. Griffin, Steven A. Abrams 117

Intrinsic Labeling of Plants for Bioavailability Studies / Janet A. Novotny, Steven Britz, Frances Caulfield, Gary Beecher, Beverly Clevidence 131

Elemental Mass Spectrometry for Compartmental Biological Modeling / Assad Al-Ammar, Ramon M. Barnes 141

Modeling of Vitamins, Minerals, and Cholesterol

The Use of Model-Based Compartmental Analysis to Study Vitamin a Metabolism in a Non-Steady State / Michael H. Green, Joanne Balmer Green 159

Modeling Short (7 Hour)- and Long (6 Week)-Term Kinetics of Vitamin B-6 Metabolism with Stable Isotopes in Humans / Stephen P. Coburn, Douglas W. Townsend, Karen L. Ericson, Robert D. Reynolds, Paula J. Ziegler, David L. Costill, J. Dennis Mahuren, Wayne E. Schaltenbrand, Thomas A. Pauly, Yao Wang, William J. Fink, David R. Pearson, David L. Hachey 173

Calcium Utilization in Young Women: New Insights from Modeling / Meryl E. Wastney, Berdine R. Martin, Rebecca J. Bryant, Connie M. Weaver 193

Modeling Cholesterol in Humans: Update and Dealing with the Problem of Exchange in Vivo Using the Blood Cell-Lipoprotein Paradigm / Charles C. Schwartz, Julie M. VandenBroek, Patricia S. Cooper 207

Modeling of Protein Metabolism, Energy, and Growth

Challenging the Assumptions in Estimating Protein Fractional Synthesis Rate Using a Model of Rodent Protein Turnover / Heidi A. Johnson, Chris C. Calvert, Kirk C. Klasing 221

Simulating Patterns of Change in Rates of Secretion of Protein into Milk / John Cant 239

Mechanistic Equations to Represent Digestion and Fermentation / Richard A. Kohn 253

Modeling Growth of Cattle for Application Within the Structure of the Cornell Net Carbohydrate and Protein System / Danny G. Fox, Michael E. Van Amburgh 267

Modeling to Explore Disease

Mathematical Models of Tumor Growth: From Empirical Description to Biological Mechanism / John A. Adam 287

A Systems Modeling Approach to the Study of Retinoid Function: Implications for Evaluation of Retinoids in Cancer Chemoprevention and/or Chemotherapy / Kevin C. Lewis, James F. Hochadel, Loren A. Zech Jr. 301

Glutamate Metabolism in Primary Cultures of Rat Brain Astrocytes: Rationale and Initial Efforts Toward Developing a Compartmental Model / Mary C. McKenna 317

State-of-the-Art Modeling Software

WinSAAM: Application and Explanation / Janet A. Novotny, Peter Greif, Raymond C. Boston 343

Stata: A Statistical Analysis System for Examining Biomedical Data / Raymond C. Boston, Anne E. Sumner 353

Using Advanced Continuous Simulation Language (ACSL) to Simulate, Solve, and Fit Mathematical Models in Nutrition / Heidi A. Johnson 371

Solving and Fitting France's Rumen Model with Mlab / Gary Knott, Daniel Kerner 389

Stella Research Software for Teaching Concepts of Nutrient Dynamics in the Undergraduate Classroom / James L. Hargrove 401

A Review of 'Scientist' Software / E. Paul Wileyto 407.

Notes:

"The 7th Conference on Mathematical Modeling in Nutrition and the Health Sciences held at the Pennsylvania State University from July 29 to August 1, 2000"--Acknowledgments.

Includes bibliographical references and index.

ISBN:

0306478811

OCLC:

52902555