Excitotoxicity in neurological diseases : new therapeutic challenge / edited by Carlo Ferrarese and M. Flint Beal.

Format:

Book

Contributor:

Ferrarese, Carlo, 1955-

Beal, M. Flint.

Language:

English

Subjects (All):

Nervous system--Diseases--Treatment.

Nervous system.

Neurotoxic agents.

Nervous system--Degeneration--Treatment.

Neurotoxicology.

Nervous System Diseases--therapy.

Nervous system--Degeneration.

Medical Subjects:

Nervous System Diseases--therapy.

Physical Description:

x, 362 pages : illustrations ; 25 cm

Place of Publication:

Boston : Kluwer Academic, [2004]

Contents:

Part I Basic mechanisms

1. Contribution of astrocyte glutamate release to excitotoxicity / Daniela Rossi, Paola Bezzi, Maria Domercq, Liliana Brambilla, Jacopo Meldolesi, Andrea Volterra 13

2. Glutamate uptake and transporters / Danbolt N.C., Holmseth S., Skar A., Lehre K.P., Furness D.N. 27

3. NMDA receptors / Fabrizio Gardoni, Flaminio Cattabeni, Monica Di Luca 51

4. AMPA receptor and synaptic plasticity / Maria Passafaro, Carlo Sala 65

5. Metabotropic glutamate receptors and neurodegeneration / Valeria Bruno, Giuseppe Battaglia, Ferdinando Nicoletti 79

6. Mechanisms of excitotoxicity and excitoprotection / Mark P. Mattson 103

Part II Acute and chronic neurological disorders

7. Epilepsy and seizures: excitotoxicity or excitotrophicity? / Karen Gale 137

8. Excitotoxicity in cerebral ischemia / Alberto Chiarugi, Elena Meli, Andrea Cozzi, Flavio Moroni, Domenico E. Pellegrini-Giampietro 171

9. Excitotoxicity and traumatic brain injury / Niklas Marklund, John F. Stover, Tracy K. McIntosh 189

10. Excitotoxicity in amyotrophic lateral sclerosis: selective vulnerability of motor neurons / Tiziana Mennini, Caterina Bendotti 217

11. Glutamate transmission in the pathogenesis of Parkinson's disease / Antonio Pisani, Paolo Calabresi 229

12. Excitotoxicity in Huntington's Disease / M. Flint Beal 243

13. The glutamatergic system in Alzheimer's disease brain: dysfunction associated with amyloid [beta]-peptide and oxidative stress / Allan D. Butterfield 251

14. Neurotoxicity and prion disease / Judyth Sassoon, Filmore Banks, David R. Brown 263

15. Glutamate excitotoxicity in multiple sclerosis / David Pitt, Cedric S. Raine 285

16. HIV-1 associated dementia / Marcus Kaul, Stuart A. Lipton 305

17. Markers of excitotoxicity in patients: tool for diagnosis or therapy? / Simone Beretta, Angelo Aliprandi, Carlo Ferrarese 317

18. Anti-excitotoxic therapies in neurological diseases: current evidences and new perspectives / Laura Brighina, Angelo Aliprandi, Simone Beretta, Carlo Ferrarese 339.

Notes:

Includes bibliographical references and index.

ISBN:

1402076800

OCLC:

53084093