Suicide gene therapy : methods and reviews / edited by Caroline J. Springer.

Format:

Book

Contributor:

Springer, Caroline J.

Series:

Methods in molecular medicine

Language:

English

Subjects (All):

Cancer--Gene therapy.

Cancer.

Neoplasms--therapy.

Genetic Therapy--methods.

Medical Subjects:

Neoplasms--therapy.

Genetic Therapy--methods.

Physical Description:

xiv, 555 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Totowa, N. J. : Humana Press, [2004]

Summary:

Suicide gene therapy has become a major element in anticancer gene therapy and holds great promise for the future. In Suicide Gene Therapy: Methods and Reviews, prominent researchers and clinicians comprehensively detail the theory and practice of this exciting and elegant therapeutic approach. In their multidisciplinary treatment, the authors cover all the major aspects of suicide gene therapy, including the design and use of vectors in gene transduction, various enzyme and prodrug systems, the mechanistic analysis of the bystander effect, the design and synthesis of prodrugs, the immunological implications, and its clinical impact. They also describe and expound upon all the cutting-edge methods needed to explore, study, and advance understanding of the basic biology underlying gene therapy. Each fully tested method includes step-by-step instructions, a discussion of the principle behind the technique, equipment and reagent lists, tips on troubleshooting and avoiding pitfalls, and notes on the interpretation and use of results. Authoritative and up-to-date, Suicide Gene Therapy: Methods and Reviews not only summarizes our knowledge of suicide gene therapy today, but also provides the experimental means to advance its future development and therapeutic applications.

Contents:

1 Introduction to the Background, Principles, and State of the Art in Suicide Gene Therapy / Ion Niculescu-Duvaz, Caroline J. Springer 1

2 Introduction to Vectors for Suicide Gene Therapy / Caroline J. Springer 29

3 Construction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Humans / Kenneth Brooks Low, Martina Ittensohn, Xiang Luo, Li-Mou Zheng, Ivan King, John M. Pawelek, David Bermudes 47

4 Nonreplicating DNA Viral Vectors for Suicide Gene Therapy: The Adenoviral Vectors / Masato Yamamoto, David T. Curiel 61

5 Replication-Selective Oncolytic Adenoviruses / Gunnel Hallden, Stephen H. Thorne, Jingping Yang, David H. Kirn 71

6 Retroviral Vectors for Suicide Gene Therapy / Colin Porter 91

7 Nonviral Liposomes / Andrew D. Miller 107

8 Peptide- and Polymer-Based Gene Delivery Vehicles / Richard Brokx, Jean Gariepy 139

9 Design of Prodrugs for Suicide Gene Therapy / Dan Niculescu-Duvaz, Ion Niculescu-Duvaz, Caroline J. Springer 161

10 Cytochrome P450-Based Gene Therapies for Cancer / E. Antonio Chiocca, David J. Waxman 203

11 Tumor Sensitization to Purine Analogs by E. coli PNP / Kimberly V. Curlee, William B. Parker, Eric J. Sorscher 223

12 Enzyme

Prodrug Systems: Carboxylesterase/CPT-11 / Mary K. Danks, Philip M. Potter 247

13 Enzyme

Prodrug Systems: Thymidine Phosphorylase/5'-Deoxy-5-Fluorouridine / Alexandre Evrard, Joseph Ciccolini, Pierre Cuq, Jean-Paul Cano 263

14 Methods to Improve Efficacy in Suicide Gene Therapy Approaches: Targeting Prodrug-Activating Enzymes Carboxypeptidase G2 and Nitroreductase to Different Subcellular Compartments / Silke Schepelmann, Robert Spooner, Frank Friedlos, Richard Marais 279

15 Extracellular [beta]-Glucuronidase for Gene-Directed Enzyme

Prodrug Therapy / Sabine Brusselbach 303

16 Enhancement of Suicide Gene Prodrug Activation by Random Mutagenesis / Jean-Emmanuel Kurtz, Margaret E. Black 331

17 Combination Suicide Gene Therapy / Wolfgang Uckert, Brian Salmons, Christian Beltinger, Walter H. Gunzburg, Thomas Kammertons 345

18 Immune Response to Suicide Gene Therapy / Shigeki Kuriyama, Hirohisa Tsujinoue, Hitoshi Yoshiji 353

19 Targeting Cancer With Gene Therapy Using Hypoxia as a Stimulus / Gabi U. Dachs, Olga Greco, Gillian M. Tozer 371

20 Radiation-Activated Antitumor Vectors / Simon D. Scott, Brian Marples 389

21 In Vitro and In Vivo Models for the Evaluation of GDEPT: Quantifying Bystander Killing in Cell Cultures and Tumors / William R. Wilson, Susan M. Pullen, Alison Hogg, Stephen M. Hobbs, Frederik B. Pruijn, Kevin O. Hicks 403

22 Suicide Gene Therapy in Liver Tumors / Long R. Jiao, Roman Havlik, Joanna Nicholls, Steen Lindkaer Jensen, Nagy A. Habib 433

23 Clinical Trials With GDEPT: Cytosine Deaminase and 5-Fluorocytosine / Nicola L. Brown, Nicholas R. Lemoine 451

24 The Nitroreductase/CB 1954 Enzyme

Prodrug System / Nicola K. Green, David J. Kerr, Vivien Mautner, Peter A. Harris, Peter F. Searle 459

25 Side Effects of Suicide Gene Therapy / Marjolijn M. van der Eb, Bertie de Leeuw, Alex J. van der Eb, Rob C. Hoeben 479

26 Antibody-Directed Enzyme

Prodrug Therapy / R. Barbara Pedley, Surinder K. Sharma, Robert E. Hawkins, Kerry A. Chester 491

27 Bioreductive Prodrugs for Cancer Therapy / Beatrice Seddon, Lloyd R. Kelland, Paul Workman 515.

Notes:

Includes bibliographical references and index.

ISBN:

0896039714

OCLC:

52514368