Nuclear envelope dynamics in embryos and somatic cells / [edited by] Philippe Collas.

Format:

Book

Contributor:

Collas, Philippe, 1966-

Series:

Molecular biology intelligence unit ; 23.

Molecular biology intelligence unit ; 23

Language:

English

Subjects (All):

Nuclear membranes.

Membrane proteins.

Physical Description:

174 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Georgetown, Tex., U.S.A. : Landes Bioscience/Eurekah.com ; New York, N.Y., U.S.A. : Kluwer Academic/Plenum Pub., [2002]

Contents:

1. Dynamics of the Vertebrate Nuclear Envelope / Malini Mansharamani, Katherine L. Wilson, James M. Holaska 1

Interphase Nuclear Envelope Structure 1

Nuclear Envelope Disassembly 3

Nuclear Assembly 5

2. Dynamics of Nuclear Envelope Proteins During the Cell Cycle in Mammalian Cells / Jan Ellenberg 15

Why Should Nuclear Envelope Proteins Be Dynamic? 15

What is the Nuclear Envelope Made of? 16

Studying Nuclear Envelope Protein Dynamics 17

Dynamics in Interphase 17

Chromosomes Do not Move Much in Interphase 21

Dynamics in Mitosis 21

INM Proteins: Switching Retention Off and Back On 21

Lamina: Tearing of a Polymer, Dispersion and Re-Import of Monomers 23

Pore Complex Disassembly and Assembly: Many Open Questions 24

Chromosomes: A Complex Template for Nuclear Assembly 25

3. Targeting and Retention of Proteins in the Inner and Pore Membranes of the Nuclear Envelope / Cecilia Ostlund, Wei Wu, Howard J. Worman 29

Targeting of Integral Membrane Proteins to the Inner Nuclear Membrane 29

Targeting and Retention of Integral Membrane Proteins to the Pore Membrane 35

Targeting of Peripheral Membrane Proteins to the Inner Nuclear Membrane 36

4. Dynamic Connections of Nuclear Envelope Proteins to Chromatin and the Nuclear Matrix / Roland Foisner 43

Major Components of the Peripheral Nuclear Lamina 44

Lamina Proteins in the Nuclear Interior 46

Interactions at the Interface Between the Lamina and the Nuclear Scaffold/Chromatin 47

Potential Functions of Lamina Proteins in Interphase 49

Dynamics and Functions of Lamina-Chromatin Interactions During Mitosis 50

Conclusions and Future Prospects 53

5. Role of Ran GTPase in Nuclear Envelope Assembly / Chuanmao Zhang, Paul R. Clarke 61

Control of Nuclear Envelope Assembly by Ran 64

6. Mitotic Control of Nuclear Pore Complex Assembly / Khaldon Bodoor, Brian Burke 73

The Nuclear Lamina 73

The Inner Nuclear Membrane 73

Nuclear Pore Complexes 74

Dynamics of the Nuclear Envelope During Mitosis 76

Nuclear Envelope Breakdown 76

Nuclear Envelope Reformation 77

NPC Assembly 77

When Does the NPC Become Functional? 81

7. Structure, Function and Biogenesis of the Nuclear Envelope in the Yeast Saccharomyces cerevisiae / George Simos 87

Overview of the Yeast NPC and its Function in Transport 88

Composition and Structure-Function Relationships of the Yeast NPC 89

Biogenesis of the Yeast NPCs and Their Role in the Organization of the NE 93

Integral Membrane Proteins of the Yeast NE and Their Function 96

8. Nuclear Envelope Brakdown and Reassembly in C. elegans: Evolutionary Aspects of Lamina Structure and Function / Yonatan B. Tzur, Yosef Gruenbaum 103

The Structure and Protein Composition of the Nuclear Lamina in C. elegans 103

Possible Functions of the Nuclear Lamina in C. elegans 104

Nuclear Dynamics in C. elegans During Mitosis 106

9. Nuclear Envelope Assembly in Gametes and Pronuclei / D. Poccia, T. Barona, P. Collas, B. Larijani 111

Sperm Nuclear Envelope Disassembly 112

Membrane Vesicle Fractions Contributing to the Nuclear Envelope 113

Binding of Egg Cytoplasmic Vesicles to Sperm Chromatin and Nuclear Envelope Remnants 115

Fusion of Nuclear Envelope Precursor Vesicles 117

Completion of Male Pronuclear Envelope Formation 123

Comparison with Other Systems and Speculations 123

Issues for Future Investigation 127

10. Nuclear Envelope Dynamics in Drosophila Pronuclear Formation and in Embryos / Mariana F. Wolfner 131

Drosophila Nuclear Envelopes 131

Developmental Changes in Nuclear Envelopes Around the Time of Fertilization 132

11. The Distribution of Emerin and Lamins in X-Linked Emery-Dreifuss Muscular Dystrophy / G. E. Morris, S. Manilal, I. Holt, D. Tunnah, L. Clements, F.L. Wilkinson, C.A. Sewry, Nguyen thi Man 143

A Brief History of EDMD 143

The Normal Distribution of Emerin and Lamins 145

Distribution of Emerin and Lamins in X-Linked EDMD 148

12. Laminopathies: One Gene, Two Proteins, Five Diseases / Corinne Vigouroux, Gisele Bonne 153

Disorders of Cardiac and/or Skeletal Muscles Linked to LMNA Alterations 154

Lipodystrophies and the Familial Partial Lipodystrophy of the Dunnigan Type (FPLD) 159

Familial Partial Lipodystrophy of the Dunnigan Type (FPLD) 162

Could Some Patients with LMNA Mutations be Affected by Both Skeletal or Cardiac Muscular Symptoms and Lipodystrophy? 163

Experimental Models of Lamin A/C Alterations 163

Nuclear Alterations in Cells Harboring LMNA Mutations 164.

Notes:

Includes bibliographical references and index.

ISBN:

0306474395

OCLC:

50958884