Ceramide signaling / [edited by] Anthony H. Futerman.

Format:

Book

Contributor:

Futerman, Anthony H.

Series:

Molecular biology intelligence unit ; 21.

Molecular biology intelligence unit ; 21

Language:

English

Subjects (All):

Ceramides.

Cellular signal transduction.

Physical Description:

4 unnumbered pages of plates, 162 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Georgetown, Tex. U.S.A. : Landes Bioscience/Eurekah.com ; New York, N.Y., U.S.A. : Kluwer Academic/Plenum Pub., [2002]

Summary:

The volume assembles current information on the role of ceramide as a signalling molecule in 16 chapters written by leading workers in this area. Specific attention is given to mechanisms of analysis of ceramide and its biophysical properties, on enzymes of ceramide metabolism and down-stream targets of ceramide, on the cross-talk of ceramide signalling with other signalling pathways, and on the role of ceramide in neuronal signalling. Finally, the book closes with a section on the therapeutic implications of ceramide action, in the areas of cannabinoid action, chemotherapy, and atherosclerosis, and illustrates the potential medical significance of delineating the roles of ceramide in cell signalling. This is the first volume specifically devoted to ceramide signalling, and will act as an invaluable resource for basic and medical researchers and graduate students wishing to get a state of the art overview of this rapidly moving field.

Contents:

1. Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass Spectrometry / Alfred H. Merrill, Jr., M. Cameron Sullards, Jeremy C. Allegood, Elaine Wang, Stephen C. Linn, Lindsay Andras, Dennis C. Liotta, Michaela Hartl, Hans-Ulrich Humpf 1

Inhibition of Ceramide Synthase 1

Analysis of Sphingolipids in Fumonisin-Treated Cells 2

Analysis of Sphingolipids by Electrospray Tandem Mass Spectrometry 2

Effects of Fumonisin B1 on Sphingolipid Metabolism 3

Additional Findings with Aminopentols and Other Sphingoid Base- Analogs 5

2. Ceramide in Apoptosis: Possible Biophysical Foundations of Action / Paavo K. J. Kinnunen, Juha M. Holopainen 9

Topology of Ceramide Formation 10

Ceramide

From Simple Structure to Complex Behavior 11

Impact of Ceramide on Biomembranes

Further Hypotheses 14

3. Ceramide-Mediated Receptor Clustering / Erich Gulbins, Heike Grassme 21

Ceramide Functions in Sphingolipid Enriched Membrane Rafts 22

Ceramide-Mediated Signaling Platforms as a General Signaling Motif? 24

4. Ceramidases: Regulators of Turnover of Ceramide and Ceramide-Mediated Responses / Cungui Mao, Lina Obeid 29

Acid Ceramidases 31

Neutral/Alkaline Ceramidases 32

Alkaline Ceramidases 35

5. Molecular Evolution of Neutral Ceramidase: From Bacteria to Mammals / Makoto Ito, Nozomu Okino, Motohiro Tani, Susumu Mitsutake, Katsuhiro Kita 41

Classification of Ceramidases 41

Bacterial Ceramidase 42

Neutral Ceramidase in Mammals 45

6. The Role of Serine/Threonine Protein Phosphatases in Ceramide Signaling / Charles E. Chalfant, Yusuf A. Hannun 49

Identification of a Ceramide-Activated Protein Phosphatase (CAPP) 49

In Vitro Regulation of CAPP by Ceramide 50

Selective CAPP Substrates in Cells 51

Role of Endogenous Ceramide in Regulating CAPP Activity 54

General Mechanisms Regulated by Ceramide-Activated Protein Phosphatases 55

Regulation of mRNA Processing as a Specific Pathway Regulated by CAPP 57

7. Kinase Suppressor of Ras as a Ceramide-Activated Protein Kinase / D. Brent Polk, Jose Lozano, Richard N. Kolesnick 63

KSR Structure and Activity 64

Mechanisms of KSR Activation 65

Mechanisms of Raf-1 Activation via KSR 66

Subcellular Localization 67

Role of KSR Phosphorylation Sites 68

Biological Effects of KSR 68

8. Ceramide in Apoptosis: The FAN Thesis, Not a Fantasy / Bruno Segui, Olivier Cuvillier, Sophie Malagarie-Cazenave, Sophie Leveque, Valerie Gouaze, Nathalie Andrieu-Abadie, Thierry Levade 73

Apoptosis, Ceramide and Sphingomyelinases 73

FAN: A Link Between TNF-R1 and Ceramide Production 74

FAN and TNF-R1- and CD40-Mediated Apoptosis 74

FAN and Other Effects 76

Conclusion: Is Ceramide in Apoptosis Still a FANtasy? 78

9. The Cross-Talk Between Nitric Oxide and Ceramide and Its Role in Apoptosis Regulation / Rico Barsacchi, Clara Sciorati, Emilio Clementi 81

Nitric Oxide Regulates Ceramide Generation 82

Ceramide Regulates Nitric Oxide Generation 82

The Cross-Talk Between Nitric Oxide and Ceramide in the Context of Apoptosis 84

10. Crosstalk of Ceramide with Cell Survival Signaling / Toshiro Okazaki, Tadakazu Kondo, Mitsumasa Watanabe, Yoshimitsu Taguchi, Takeshi Yabu 91

Regulation of PI-3 Kinase-Dependent Signaling by Ceramide 94

Regulation of Ceramide-Related Signaling by PI-3 Kinase 95

11. Ceramide in the Regulation of Neuronal Development: Two Faces of a Lipid / Christian Riebeling, Anthony H. Futerman 101

Ceramide and Neuronal Development and Death 101

Neurotrophins as Modulators of Neuronal Survival and Death 102

Sphingomyelinases and their Regulation 103

Downstream Players in the Ceramide Response 104

A Role for de novo Ceramide Synthesis 106

Signaling Through Ceramide Metabolites 106

12. Neurons, Neurotrophins and Ceramide Signaling: Do Domains and Pores Contribute to the Dichotomy? / Rick T. Dobrowsky 113

Influence of Ceramide on Lipid Raft Domains 114

Effect of Ceramides on Sphingomyelin-Cholesterol Poor Membranes 115

Are There any Relationships between Neurotrophins, Ceramide, Lipid Rafts and Neuronal Biology? 117

13. Ceramide Signaling in Cannabinoid Action / Ismael Galve-Roperh, Cristina Sanchez, Teresa Gomez del Pulgar, Guillermo Velasco, Daniel Rueda, Cristina Blazquez, Manuel Guzman 125

Ceramide Generation 127

Ceramide Targets 129

Ceramide Function 129

Therapeutic Implications 130

14. Ceramide Glycosylation and Chemotherapy Resistance / Myles C. Cabot 133

15. Ceramide in Serum Lipoproteins: Function and Regulation of Metabolism / Mariana N. Nikolova-Karakashian 141

Ceramide is a Component of Serum Lipoproteins 142

Secretion of Ceramide in the Form of VLDL by the Liver 142

Generation of Ceramide in LDL Particles 143

Biological Consequences of Elevation of Ceramide Concentrations in LDL 145

16. Therapeutic Implications of Ceramide-Regulated Signaling Cascades / Mark Kester, Jong K. Yun, Tom Stover, Lakshman Sandirasegarane 149

The Bench

Ceramides and Signaling Cascades 149

The Bedside

Ceramides and Cardiovascular Disease 150

Ceramides and Cancer 153

Other Potential Applications for Ceramide-Based Therapeutics 155

Conclusions

Back to the Bench 155.

Notes:

Includes bibliographical references and index.

ISBN:

0306474425

OCLC:

51060183