Brain hypothermia treatment / N. Hayashi, D. W. Dietrich.

Format:

Book

Author/Creator:

Hayashi, N. (Nariyuki)

Contributor:

Dietrich, D. W. (Dalton W.), 1952-

Language:

English

Subjects (All):

Brain damage--Treatment.

Brain damage.

Cold--Therapeutic use.

Cold.

Hypothermia, Induced.

Brain Injuries--therapy.

Medical Subjects:

Hypothermia, Induced.

Brain Injuries--therapy.

Physical Description:

xv, 325 pages : illustrations ; 29 cm

Place of Publication:

Tokyo ; New York : Springer, 2004.

Summary:

Recent breakthroughs in understanding the effectiveness of brain hypothermia treatment have been brought about by rapid progress in experimental gene studies along with new findings in the areas of brain-injury mechanisms, brain thermo-pooling, hemoglobin dysfunction, insulin-resistant hyperglycemia, radical damage involving states of consciousness, management of lipid-dominant metabolism in the intensive care unit (ICU), and management of immune crises under conditions of hypothermia. This book explains the mechanism of brain hypothermia and presents advanced techniques for ICU management of brain hypothermia for critically brain-injured patients. Especially useful for bedside care in the ICU are the easy-reference care-management "cards" in the appendix of the book. Brain Hypothermia Treatment provides a valuable resource and practical guide for professionals in the fields of neurosurgery and emergency and critical care medicine.

Contents:

Basic Research / D.W. Dietrich

1. Global and Focal Cerebral Ischemia 7

2. Limitations of Postischemic Hypothermia 9

3. The Importance of Chronic Outcome Measures in Assessing Neuroprotective Strategies 10

4. Traumatic Brain Injury 12

5. Traumatic Axonal Injury 14

6. Behavioral Improvements with Posttraumatic Hypothermia 16

7. Brain Tissue Temperature Measurements in Clinical Setting 18

8. Traumatic and Ischemic Hyperthermia 19

9. Rewarming Phase 20

10. Therapeutic Hypothermia in Complicated Models of Traumatic Brain Injury 21

11. Mechanisms of Hypothermic Protection 22

12. Excitotoxicity 23

13. Free Radical Production 24

14. Decrease of Vascular Permeability 25

15. Nitric Oxide 26

16. Cerebral Blood Flow 27

17. Inflammation 28

18. Gene Expression and Apoptosis 30

19. Summary and Future Directions 32

Clinical Management / N. Hayashi

II. Overview of Clinical Development of Brain Hypothermia Treatment

20. Mechanism of Brain Damage and Management of Severe Brain Injury Based on Laboratory Studies 43

21. History of Clinical Trials of Hypothermia Treatment of Severe Brain Injury 51

22. Secondary Brain Injury Mechanism of Hypothalamus

Pituitary

Adrenal Axis Neurohormonal Activation in Severely Brain-Injured Patients 55

23. Clinical Failures of Previous Hypothermia Management 68

24. The Difference in Brain Injury Mechanism in Experimental Laboratory Models and Human Patients 74

25. The Regulatory Mechanism of Brain Tissue Temperature and Brain Thermo-pooling 76

26. The Target of Treatment of Severe Brain Injury in the Acute Stage 78

27. New Concept of Brain Hypothermia Treatment 85

III. Approach to Brain Hypothermia Treatment

28. Contraindications 95

29. Indications 97

30. Beyond Indication and Contraindication 98

IV. The Technique of Brain Hypothermia Treatment

31. Induction of Brain Hypothermia 103

32. The Protocol for Brain Hypothermia Treatment 106

33. Mistakes and Pitfalls of Brain Hypothermia Treatment 110

34. Concepts in Brain Tissue Temperature Control 120

35. Management of Brain Tissue Temperature 125

36. Intensive Care Unit Bed Design for Brain Hypothermia 132

37. Design of the Intensive Care Unit for Brain Hypothermia Treatment 133

38. Preparation for Management of Brain Hypothermia 134

39. Noninvasive Monitoring of Brain Damage 137

40. Neuron Protection in Injured Brain Tissue During Surgery 141

41. Prolonged Anesthesia for Brain Hypothermia Treatment in ICU 145

42. Imaging and Monitoring for Brain Hypothermia Management 147

43. Induction of Brain Hypothermia Treatment 165

44. Management During the Cooling Stage 175

45. Timing of Rewarming 217

46. Preconditioning for Rewarming 219

47. Management of Rewarming 224

V. Prevention of Memory Disturbances and Vegetative State

48. Clinical Issues in the Management of Unconsciousness and Vegetative State Patients 235

49. The New Concept of Unconsciousness and Mechanism of Vegetation 237

50. Diagnosis of Reversibility of the Vegetative State 241

51. Management of Complicated Neuronal Dysfunction: Emotion, Memory, Cognition, and Behavior 243

52. Surgical Management After Brain Hypothermia Treatment to Prevent Vegetation and Memory Disturbance 245

53. Indications and Criteria for Dopamine Replacement Therapy 246

VI. Specific Consideration for Disease: Cardiac Arrest, Occlusive Cerebral Stroke, and Subarachnoid Hemorrhage

54. Brain Hypothermia After Resuscitation from Cardiopulmonary Arrest 249

55. Brain Hypothermia for Occlusive Cerebral Stroke 254

56. Special Consideration of Brain Hypothermia Treatment for Subarachnoid Hemorrhage 258

VII. Clinical Outcome of Brain Hypothermia Treatment

57. Severe Brain Trauma 269

58. Cardiac Arrest 272

VIII. Clinical Protocol for Application of Brain Hypothermia

59. Critical Path of Brain Hypothermia Treatment 277.

Notes:

Includes bibliographical references and index.

ISBN:

4431404465

OCLC:

53183648