The macrophage as therapeutic target / editor, Siamon Gordon ; contributors, J.M. Aerts ... [and others]

Format:

Book

Contributor:

Gordon, Siamon.

Series:

Handbook of experimental pharmacology ; v. 158.

Language:

English

Subjects (All):

Macrophages.

Drug targeting.

Macrophages--immunology.

Antigen Presentation--drug effects.

Drug Delivery Systems.

Drug Therapy--methods.

Phagocytosis--drug effects.

Medical Subjects:

Macrophages--immunology.

Antigen Presentation--drug effects.

Drug Delivery Systems.

Drug Therapy--methods.

Phagocytosis--drug effects.

Physical Description:

x, 496 pages : illustrations ; 24 cm.

Place of Publication:

Berlin ; New York : Springer, [2003]

Contents:

The Macrophage as a Validated Pharmaceutical Target / H. Rosen 3

Transcription Factors that Regulate Macrophage Development and Function / D.A. Hume, S.R. Himes 11

Exploitation of Macrophage Clearance Functions In Vivo / S.M. Moghimi 41

Reaching the Macrophages: Routes of Delivery / G. Kraal, N. van Rooijen 55

Antigen Presenting Cells and Vaccine Design / L. Martinez-Pomares, S. Wong 67

Macrophage-Specific Gene Targeting In Vivo / D.R. Greaves, S. Gordon 89

Part 2. Macrophage Targets in Inflammation

Integrins of Macrophages and Macrophage-Like Cells / E.J. Brown 111

Macrophage Targets in Inflammation: Purinergic Receptors / F. Di Virgilio, D. Ferrari 131

Macrophage Lipid Uptake and Foam Cell Formation / W.J.S. de Villiers, D.R. van der Westhuyzen 147

Dietary Fatty Acids and Macrophages / P.C. Calder, P. Yaqoob 173

Macrophages as Therapeutic Targets in Lysosomal Storage Disorders / J.M. Aerts, C. Hollak, R. Boot, A. Groener 193

Nuclear Receptors as Regulators of Macrophage Homeostasis and Function / J.S. Welch, C.K. Glass 209

Relationships between Reactive Oxygen Species and Reactive Nitrogen Oxide Species Produced by Macrophages / M.G. Espey 227

Proteases / J.A. Mahoney 253

Targeting the Chemokine System / Z. Johnson, A. Frauenschuh, A. Proudfoot 269

Antimicrobial Peptides / T. Ganz, R.I. Lehrer 295

Macrophage Phospholipid Products / P.M. Henson 305

Part 3. Modulation of Specialised Macrophage Activities

Dendritic Cells Versus Macrophages as Antigen-Presenting Cells: Common and Unique Features / S. Vuckovic, D.N.J. Hart 337

The Osteoclast / T.J. Chambers 353

Macrophages in the Central and Peripheral Nervous System / V.H. Perry 373

Innate Recognition of Viruses by Macrophage and Related Receptors: Potential Ligand for Antiviral Agents / J.L. Miller, S. Gordon 385

Macrophage Immunity and Mycobacterium Tuberculosis / J.D. MacMicking, J.D. McKinney 409

Detection and Control of Fungi by Macrophages: The Role of Carbohydrates and Antifungal Agents / J.A. Willment, S. Gordon, G.D. Brown 459.

Notes:

Includes bibliographical references and index.

ISBN:

3540442502

OCLC:

51992226