Development of the cardiac conduction system.

Format:

Book

Conference/Event

Contributor:

Chadwick, Derek.

Goode, Jamie.

Novartis Foundation.

Conference Name:

Symposium on Development of the Cardiac Conduction System (2002 : Novartis Foundation)

Series:

Novartis Foundation symposium ; 250.

Novartis Foundation symposium ; 250

Language:

English

Subjects (All):

Heart conduction system--Congresses.

Heart conduction system.

Heart--Growth--Congresses.

Heart.

Heart Conduction System--anatomy & histology.

Heart--Growth.

Heart Conduction System--physiology.

Myocardium--cytology.

Medical Subjects:

Heart Conduction System--anatomy & histology.

Heart Conduction System--physiology.

Myocardium--cytology.

Genre:

Conference papers and proceedings.

Physical Description:

ix, 289 pages : illustrations ; 24 cm.

Place of Publication:

Chichester, UK ; Hoboken, NJ : Wiley, 2003.

Summary:

The heart beats an estimated three billion times during the lifespan of the average person. Each of these cycles of contraction depends on specialized cardiac tissues involved in the rhythmic generation and coordinated spread of electrical excitation. Collectively, these tissues are known as the pacemaking and conduction system -- the PCS. Since the PCS is vital for generating and synchronizing the heartbeat, its dysfunction can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. Recent advances have meant that the cellular and molecular mechanisms governing the development of the PCS in tissues are now starting to be understood. This book brings together a group of leading researchers to discuss emerging concepts in this exciting field. In particular, the new understanding of the cellular origin and the molecular induction of PCS tissues during embryogenesis, together with the burgeoning technology of stem cell manipulation, provides the foundation for tissue engineering, replacement and repair of PCS tissues in humans. The book also identifies therapeutic targets arising from basic discoveries in the developmental biology of cardiac pacemaking and conduction tissues.

Contents:

The morphology of the cardiac conduction system / Robert H. Anderson, Siew Yen Ho 6

Development of the cardiac conduction system: a matter of chamber development / Antoon F. M. Moorman, Vincent M. Christoffels 25

Mouse models for cardiac conduction system development / Andy Wessels, Aimee Phelps, Thomas C. Trusk, Dorene L. Davis, Angela V. Edwards, John B. E. Burch, Amy L. Juraszek 44

Developmental transitions in cardiac conduction / Michiko Watanabe, Emil Thomas Chuck, Florence Rothenberg, David S. Rosenbaum 68

Gap junctional connexins in developing mouse cardiac conduction system / L. Miquerol, L. Dupays, M. Theveniau-Ruissy, S. Alcolea, T. Jarry-Guichard, P. Abran, D. Gros 80

His

Purkinje lineages and development / Robert G. Gourdie, Brett S. Harris, Jacqueline Bond, Angela M. Edmondson, Gang Cheng, David Sedmera, Terrence X. O'Brien, Takashi Mikawa, Robert P. Thompson 110

The role of neural crest and epicardium-derived cells in conduction system formation / Adriana C. Gittenberger-de Groot, Nico M. Blom, Naoyoshi Aoyama, Henri Sucov, Arnold C. G. Wenink, Robert E. Poelmann 125

Induction and patterning of the Purkinje fibre network / Takashi Mikawa, Robert G. Gourdie, Kimiko Takebayashi-Suzuki, Nobuyuki Kanzawa, Jeanette Hyer, David J. Pennisi, Clifton P. Poma, Maxim Shulimovich, Kevin G. Diaz, John Layliev, Aparna Prasad 142

The oldest, toughest cells in the heart / Robert P. Thompson, Maria Reckova, Angela de Almeida, Michael R. Bigelow, Chiffvon P. Stanley, Joshua B. Spruill, Thomas T. Trusk, David Sedmera 157

Transcriptional regulation in the mouse atrioventricular conduction system / Angela V. Edwards, Dorene L. Davis, Amy L. Juraszek, Andy Wessels, John B. E. Burch 177

Patterning of the mouse conduction system / Stacey Rentschler, Gregory E. Morley, Glenn I. Fishman 194

Clinical pathology of the cardiac conduction system / Siew Yen Ho 210

Cardiac conduction and arrhythmia: insights from Nkx2.5 mutations in mouse and humans / Patrick Y. Jay, Charles I. Berul, Makoto Tanaka, Masao Ishii, Yoshihisa Kurachi, Seigo Izumo 227

The genetic origin of atrioventricular conduction disturbance in humans / D. Woodrow Benson 242

Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease / Tara R. St. Amand, Jonathan T. Lu, Kenneth R. Chien 260.

Notes:

"Symposium on Development of the Cardiac Conduction System, held at the Novartis Foundation, London, May 21-23, 2002"--Contents p.

"Editors, Derek J. Chadwick (organizer) and Jamie Goode"--Contents p.

Includes bibliographical references and indexes.

ISBN:

0470850353

OCLC:

52127988