TOR : Target of Rapamycin / G. Thomas, D. M. Sabatini, M.N. Hall (eds.).

Format:

Book

Contributor:

Thomas, G. (George), 1947-

Sabatini, D. M. (David M.)

Hall, M. M.

Series:

Current topics in microbiology and immunology ; v. 279.

Current topics in microbiology and immunology ; v. 279

Language:

German

Subjects (All):

Rapamycin.

Sirolimus.

Medical Subjects:

Sirolimus.

Physical Description:

x, 264 pages : 56 illustrations (9 color). ; 24 cm.

Other Title:

Target of Rapamycin

Place of Publication:

Berlin ; New York : Springer, 2004.

Summary:

TOR, the Target of Rapamycin, is an atypical protein kinase discovered a little over ten years ago in S. cerevisiae by a genetic selection for mutants resistant to the anti-mycotic effects of rapamycin. Since that time, orthologues have been identified in all eukaryotes examined, including humans. Recent studies have placed TOR in signalling pathways that link nutrient sensing and the regulation of major anabolic and catabolic responses. Thus, TOR is a central controller of cell growth. The significance of understanding the molecular mechanisms that control TOR function has been underscored by current clinical trials showing that rapamycin is therapeutically important not only as an immunosuppressant, but also as an efficacious drug in the treatment of several pathological conditions, including cancer, inflammation, and restenosis. Given its fundamental role in cell growth control and human disease, a great deal of attention has been drawn to TOR. Here we have gathered the leading figures in the field to summarize their own contributions to uncovering TOR function, and to speculate where the field will be moving in the next few years.

Contents:

TOR: The First Ten Years / A. Lorberg, M.N. Hall 1

The Role of Phosphatases in TOR Signaling in Yeast / K. Duvel, J.R. Broach 19

Yeast TOR Signaling: A Mechanism for Metabolic Regulation / T. Powers, I. Dilova, C.-Y. Chen, K. Wedaman 39

Nutrient Signaling Through TOR Kinases Controls Gene Expression and Cellular Differentiation in Fungi / J.R. Rohde, M.E. Cardenas 53

Autophagy in Yeast: A TOR-Mediated Response to Nutrient Starvation / Y. Kamada, T. Sekito, Y. Ohsumi 73

The Fission Yeast TOR Proteins and the Rapamycin Response: an Unexpected Tale / R. Weisman 85

Plant Growth and the TOR Pathway / B. Menand, C. Meyer, C. Robaglia 97

TOR Action in Mammalian Cells and in Caenorhabditis elegans / X. Long, F. Muller, J. Avruch 115

Genetic Analysis of TOR Signaling in Drosophila / Th.P. Neufeld 139

Interplay Between Growth Factor and Nutrient Signaling: Lessons from Drosophila TOR / E. Hafen 153

mTOR Signaling to Translation / A.-C. Gingras, B. Raught, N. Sonenberg 169

Modulation of the Protein Kinase Activity of mTOR / J.C. Lawrence, Jr., T.-A. Lin, L.P. McMahon, K.M. Choi 199

Role of mTOR Signaling in the Control of Translation Initiation and Elongation by Nutrients / C.G. Proud 215

Novel Regulatory Mechanisms of mTOR Signaling / J. Chen 245

Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex / D.H. Kim, D.M. Sabatini 259

Kinase Activities Associated with mTOR / K. Yonezawa, K.-I. Yoshino, C. Tokunaga, K. Hara 271

mTOR: A Mediator of Intracellular Homeostasis / A. Jaeschke, P.B. Dennis, G. Thomas 283

mTOR as a Positive Regulator of Tumor Cell Responses to Hypoxia / R.T. Abraham 299

Retroviral Oncogenes and TOR / M. Aoki, P.K. Vogt 321

mTOR as a Target for Cancer Therapy / P.J. Houghton, S. Huang 339.

Notes:

Includes bibliographical references and index.

ISBN:

354000534X

OCLC:

53840039