Molecular staging of cancer / H. Allgayer, M. M. Heiss, F. W. Schildberg (eds.) ; with 24 figures and 25 tables.

Format:

Book

Conference/Event

Contributor:

Allgayer, H. (Heike), 1969-

Heiss, M. (Markus), 1956-

Conference Name:

International Meeting on Molecular Staging on Cancer (1st : 2001 : Klinicum Grosshadern)

Series:

Recent results in cancer research 0080-0015 ; 162.

Recent results in cancer research, 0080-0015 ; 162

Language:

English

Subjects (All):

Tumors--Classification--Congresses.

Tumors.

Tumors--Classification.

Cancer--Molecular aspects--Congresses.

Cancer.

Cancer--Molecular aspects.

Neoplasms--diagnosis.

Neoplasms--ultrastructure.

Models, Molecular.

Neoplasm Staging.

Medical Subjects:

Neoplasms--diagnosis.

Neoplasms--ultrastructure.

Models, Molecular.

Neoplasm Staging.

Genre:

Conference papers and proceedings.

Physical Description:

xi, 217 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Berlin ; New York : Springer-Verlag, [2003]

Summary:

An explosion of information has occurred since scientists began to define the molecular events that describe the malignant transformation and progression of cells and their development towards a life-threatening metastatic disease. The First International Congress on Molecular Staging of Cancer, held in Munich in December 2001, aimed to establish an international platform of exchange among molecular biologists, cell biologists, tumor immunologists, and clinical and surgical oncologists. This network approach should be fruitful for both clinicians and researchers. The highlighted topics included tumor-associated proteolysis, minimal residual disease, new approaches for molecular diagnosis and targeting, and the first molecular staging models. One session focused on technology transfer, opening up a new field of funding for innovative concepts. Finally, the impact of molecular staging on clinical strategies was discussed.

Contents:

The Urokinase Receptor (uPAR, CD87) as a Target for Tumor Therapy: uPA-Silica Particles (SP-uPA) as a New Tool for Assessing Synthetic Peptides to Interfere with uPA/uPA-Receptor Interaction / E. Guthaus, N. Schmiedeberg, M. Burgle, V. Magdolen, H. Kessler, M. Schmitt 3

Molecular Regulation of Urokinase-Receptor Gene Expression as One Potential Concept for Molecular Staging and Therapy / H. Allgayer 15

Stromal Cell Involvement in Cancer / K. Almholt, M. Johnsen 31

Inhibition of the Tumor-Associated Urokinase-Type Plasminogen Activation System: Effects of High-Level Synthesis of Soluble Urokinase Receptor in Ovarian and Breast Cancer Cells In Vitro and In Vivo / V. Magdolen, A. Kruger, S. Sato, J. Nagel, S. Sperl, U. Reuning, P. Rettenberger, U. Magdolen, M. Schmitt 43

Molecular Mechanisms of Carcinogenesis in Gastric Cancer / H. Hofler, K.-F. Becker 65

Clinical Implications of Molecular Diagnosis in Hereditary Nonpolyposis Colorectal Cancer / G. Moslein 73

Minimal Residual Disease in Gastric Cancer / H. Seeliger, H. Spatz, K.-W. Jauch 79

Minimal Residual Disease in Breast Cancer and Gynecological Malignancies: Phenotype and Clinical Relevance / F. Roggel, S. Hocke, K. Lindemann, S. Sinz, A. Welk, M. Bosl, M. Pabst, N. Nusser, S. Braun, M. Schmitt, N. Harbeck 89

Advanced Statistical Methods for the Definition of New Staging Models / R. Kates, M. Schmitt, N. Harbeck 101

Clinical Implications of the EGF Receptor/Ligand System for Tumor Progression and Survival in Gastrointestinal Carcinomas: Evidence for New Therapeutic Options / R. Kopp, E. Rothbauer, M. Ruge, H. Arnholdt, J. Spranger, M. Muders, D.G. Pfeiffer, F.W. Schildberg, A. Pfeiffer 115

2 Original Papers

Minimal Residual Disease in Bone Marrow and Peripheral Blood of Patients with Metastatic Breast Cancer / J. Bischoff, R. Rosenberg, M. Dahm, W. Janni, K. Gutschow 135

Estrogen Receptor Expression Profile of Disseminated Epithelial Tumor Cells in Bone Marrow of Breast Cancer Patients / N. Ditsch, B. Mayer, M. Rolle, M. Untch, F.W. Schildberg, I. Funke 141

Detection of Circulating Tumor Cells in Blood Using an Optimized Density Gradient Centrifugation / R. Gertler, R. Rosenberg, K. Fuehrer, M. Dahm, H. Nekarda, J.R. Siewert 149

Antitumoral and Antimetastatic Effects of Continuous Particle-Mediated Cytokine Gene Therapy / A. Dietrich, K. Kraus, U. Brinckmann, C. Stockmar, A. Muller, U.G. Liebert, M. Schonfelder 157

Genetic Subtyping of Renal Cell Carcinoma by Comparative Genomic Hybridization / K. Junker, G. Weirich, M.B. Amin, P. Moravek, W. Hindermann, J. Schubert 169

Telomere Length and hTERT Expression in Patients with Colorectal Carcinoma / R. Rosenberg, R. Gertler, D. Stricker, S. Lassmann, M. Werner, H. Nekarda, J.R. Siewert 177

Estimation of Concentration of Chosen Adhesive Factors in Suprarenal Tumours of "Incidentaloma" Type / K. Kolomecki, H. Stepien, T. Stepien, Z. Pasieka, K. Kuzdak 183

Evaluation of the Levels of bFGF, VEGF, sICAM-1, and sVCAM-1 in Serum of Patients with Thyroid Cancer / Z. Pasieka, H. Stepien, J. Komorowski, K. Kolomecki, K. Kuzdak 189

Molecular Whole-Body Cancer Staging Using Positron Emission Tomography: Consequences for Therapeutic Management and Metabolic Radiation Treatment Planning / M. Schmucking, R.P. Baum, F. Griesinger, N. Presselt, R. Bonnet, C. Przetak, A. Niesen, J. Leonhardi, E.C. Lopatta, B. Herse, T.G. Wendt 195

Recurrences of Thyroid Cancer After Radical Surgery and Complementary Treatment: Are Macroscopic, Microscopic, Scintigraphic, and Biochemical Criteria Sufficient in the Evaluation of Radicality of Primary Treatment? / L. Pomorski, J. Cywinski, K. Kolomecki, Z. Pasieka, M. Bartos, K. Kuzdak 203

Summary and Congress Report: Molecular Staging of Cancer

Concepts of Today, Therapies of Tomorrow / H. Allgayer, M.M. Heiss, F.W. Schildberg 211.

Notes:

Proceedings of the 1st International Meeting on Molecular Staging of Cancer, held December 6-8, 2001 at the Klinikum Grosshadern, Munich.

Includes bibliographical references.

ISBN:

3540434690

OCLC:

50684437