Basic clinical pharmacokinetics / Michael E. Winter.

Format:

Book

Author/Creator:

Winter, Michael E.

Language:

English

Subjects (All):

Pharmacokinetics.

Pharmacokinetics--Problems, exercises, etc.

Pharmacology, Clinical.

Medical Subjects:

Pharmacokinetics.

Pharmacology, Clinical.

Genre:

Problems and exercises.

Physical Description:

xii, 511 pages : illustrations ; 24 cm

Edition:

Fourth edition.

Place of Publication:

Philadelphia : Lippincott Williams & Wilkins, [2004]

Summary:

Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners. Part One provides a basic review of pharmacokinetic principles. Extensive explanations, graphic illustrations, and detailed algorithms teach the principles of bioavailability, volume of distribution, clearance, elimination rate constant, and half-life. Part Two explains the clinical applications of these principles. Solutions to problems commonly encountered in the practice setting are discussed for specific drugs. New to this edition are chapters on tricyclic antidepressants and cyclosporine, an expanded chapter on dialysis, and updated information on choosing equations and interpreting plasma drug concentrations.

Contents:

Bioavailability (F) 2

Administration Rate (R[subscript A]) 8

Desired Plasma Concentration (C) 10

Volume of Distribution (V) 19

Clearance (CI) 27

Elimination Rate Constant (K) and Half-Life (t1/2) 39

Maximum and Minimum Plasma Concentrations 54

Selecting the Appropriate Equation 58

Interpretation of Plasma Drug Concentrations 73

Creatinine Clearance (Cl[subscript Cr]) 97

Dialysis of Drugs 111

Part 2 Drug Monographs

1 Aminoglycoside Antibiotics 130

2 Carbamazepine 172

3 Digoxin 183

4 Ethosuximide 222

5 Immunosuppressants: Cyclosporine, Tacrolimus, and Sirolimus 228

6 Lidocaine 251

7 Lithium 265

8 Methotrexate (MTX) 274

9 Phenobarbitol 294

10 Phenytoin 321

11 Procainamide 364

12 Theophylline 388

13 Tricyclic Antidepressants: Amitriptyline, Desipramine, Imipramine, and Nortriptyline 423

14 Valproic Acid 438

15 Vancomycin 451

Appendix I Nomograms for Calculating Body Surface Area 477

Appendix II Common Equations Used Throughout the Text 479

Appendix III Algorithm for Evaluating and Interpreting Plasma Concentrations 485.

Notes:

Includes bibliographical references and index.

ISBN:

0781741475

OCLC:

52381502