Drug delivery systems in cancer therapy / edited by Dennis M. Brown.

Format:

Book

Contributor:

Brown, Dennis M., 1949-

Series:

Cancer drug discovery and development

Language:

English

Subjects (All):

Antineoplastic agents--Administration.

Antineoplastic agents.

Drug delivery systems.

Drug Delivery Systems--methods.

Neoplasms--drug therapy.

Antineoplastic Agents--administration & dosage.

Drug Delivery Systems--trends.

Medical Subjects:

Drug Delivery Systems--methods.

Neoplasms--drug therapy.

Antineoplastic Agents--administration & dosage.

Drug Delivery Systems--trends.

Physical Description:

x, 390 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2004]

Summary:

A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's chemotherapeutic cancer agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies -- including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect -- that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules. Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today.

Contents:

Part I Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine

1 Systemically Administered Drugs / Reginald B. Ewesuedo, Mark J. Ratain 3

2 Regional Administration of Antineoplastic Drugs / Maurie Markman 15

3 Theoretical Analyses and Simulations of Anticancer Drug Delivery / Ardith W. El-Kareh, Timothy W. Secomb 25

Part II Technologies Available for Use in Cancer Drug Delivery Systems

4 Biopolymers for Parenteral Drug Delivery in Cancer Treatment / Wolfgang Friess 47

5 Hydrogels in Cancer Drug Delivery Systems / Sung-Joo Hwang, Namjin Baek, Haesun Park, Kinam Park 97

6 Microparticle Drug Delivery Systems / Duane T. Birnbaum, Lisa Brannon-Peppas 117

7 Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future / Robert G. L. Shorr, Michael Bentley, Simon Zhsao, Richard Parker, Brendan Whittle 137

8 Emulsions As Anticancer Delivery Systems / S. Esmail Tabibi 175

Part III Current Applications: Products Approved or in Advanced Clinical Development

9 Liposomal Drug Delivery Systems for Cancer Therapy / Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, Keelung Hong 191

10 Gliadel: A New Method for the Treatment of Malignant Brain Tumors / Francesco DiMeco, Henry Brem, Jon D. Weingart, Alessandro Olivi 215

11 Intralesional Chemotherapy with Injectable Collagen Gel Formulations / Elaine K. Orenberg 229

12 Sustained-Release Drug Delivery with DepoFoam / Sankaram B. Mantripragada, Stephen B. Howell 247

13 Cancer Vaccines / Susanne Osanto 263

Part IV Future Directions: Novel Cancer Drug Targets and Delivery Systems

14 Gene Therapy of Cancer / Susanne Osanto 287

15 Progress in Antisense Technology / Stanley T. Crooke 311

16 Tumor Vaccines / Francesco M. Marincola 347

17 Diagnosis and Treatment of Human Disease Using Telomerase As a Novel Target / Lynne W. Elmore, Shawn E. Holt 361.

Notes:

Includes bibliographical references and index.

ISBN:

0896038882

OCLC:

51810461