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Genetic recombination in cancer / Gajanan V. Sherbet.
Holman Biotech Commons RC268.4 .S468 2003
Available
- Format:
- Book
- Author/Creator:
- Sherbet, G. V. (Gajanan V.)
- Language:
- English
- Subjects (All):
- Cancer--Genetic aspects.
- Cancer.
- Genetic recombination.
- Neoplasms--genetics.
- Recombination, Genetic.
- Medical Subjects:
- Neoplasms--genetics.
- Recombination, Genetic.
- Physical Description:
- xiv, 245 pages : illustrations ; 24 cm
- Place of Publication:
- Amsterdam ; Boston : Academic Press, 2003.
- Summary:
- The generation of cell variants possessing different genetic traits and varying, often abnormal, cell phenotypes is an important element in the initiation and development of cancer and its progression to the metastatic state. Genomic instability leading to genetic recombination appears to be the primary mechanism of generating genetic diversity and is thus a key contributor to cancer. In this book, Professor Gajanan Sherbet reviews the role of genetic recombination in the generation of intratumoral diversity in the form of cell variants that impinge upon the growth and dissemination of tumours.
- Contents:
- 2 Genetic integrity, DNA repair and recombination 3
- Base excision and nucleotide excision repair system 5
- RAD genes and their operation in DNA replication checkpoint 5
- DNA recombination repair pathway 8
- VDJ recombination, the immune system and haematological malignancy 9
- SET domain proteins in genetic transcription, growth regulation and myeloma 12
- Control of cell proliferation by SET domain proteins 12
- The generation of chimeric transcripts of NSD family genes in multiple myeloma and Wolf-Hirschhorn syndrome 14
- Ku protein in cell function 15
- Regulation of transcription by Ku protein 17
- Ku protein and DNA repair 18
- Ku protein in the maintenance of chromosomal integrity 19
- Ku protein in cell cycle progression and differentiation 19
- Ku protein in cancer 21
- 3 Replication error (RER) and genetic instability 24
- Microsatellite instability and cancer progression 25
- Effects of microsatellite instability on p53 and growth factor gene expression 28
- Influence of microsatellite instability on invasive behaviour of tumours 31
- Microsatellite instability and metastasis suppressor nm23 gene abnormalities 33
- Chromosomal fragile sites and the RER phenotype 34
- Sister chromatid recombination and fragile sites 35
- Microsatellite instability and sister chromatid recombination 39
- Genomic stability and chromosome structural dynamics 39
- 4 DNA repeats, genetic recombination and the pathogenesis of genetic disorders 41
- CAG repeat expansion and genetic instability 42
- Microsatellite dinucleotide repeats in insulin-dependent diabetes mellitus and autoimmune thyroid disease 49
- Alu repeats in genetic recombination 50
- Intrachromosomal recombination in muscular dystrophy and Alzheimer's disease mediated by Alu repeats 51
- Intrachromosomal recombination in tumour suppressor genes in cancer 52
- Alu-mediated alterations of cell cycle regulator genes 55
- Alu-mediated interchromosomal recombination in leukaemias 55
- Alu-mediated interchromosomal recombination in Ewing sarcoma 56
- Alu repeats, DNA mismatch repair gene mutation and genomic instability 57
- Alu elements in genetic transcription 57
- Mode of Alu function in recombination 58
- Functional involvement of Alu with signal recognition particles 61
- LINE repeats in genetic rearrangement 62
- Cognate elements associated with recombination 64
- Translin-binding elements 64
- Chi sequences in DNA repair and recombination 65
- 5 Chromosomal recombination in cancer 67
- Karyotypic abnormalities in cancer 67
- DNA aneuploidy and cancer progression 68
- DNA ploidy, cell proliferation and growth factor expression 70
- Association of DNA ploidy with p53 abnormalities 75
- 6 Chromosomal translocation and its phenotypic effects 76
- Chromosomal translocation and signal transduction 76
- Deregulation of notch signalling by chromosomal translocation 77
- Loss of integrity of notch signalling in leukaemia and lymphoma cells 83
- Genetic abnormalities downstream of notch signal activation 85
- Fibulins, notch signalling and cancer invasion 87
- Chromosomal translocation and the dynamics of cell population expansion in cancer 89
- The modulation of cell proliferation-related gene expression by chromosomal rearrangement 90
- Genetic rearrangement and the regulation of apoptosis by bcl2 gene family 91
- Bcl2 in p53-induced apoptosis 92
- T-cell leukaemia/lymphoma (TCL1) gene in apoptosis 95
- The PI-3 kinase/Akt pathway of signal transduction in cell proliferation, apoptosis and differentiation 96
- Akt in PTEN tumour suppressor function 97
- Akt signalling in cancer growth and invasion 97
- Akt in TCL1 function 100
- Fusion oncoprotein signalling by PI-3 kinase/Akt pathway 100
- Mechanism of transduction of signals by Akt 103
- Chromosomal translocation and genetic transcription 104
- Chromosomal translocation in synovial sarcomas 105
- AML1 fusion proteins in haematopoietic neoplasms 106
- Modulation of retinoic acid receptor function by chromosomal translocation 108
- TEL transcription-related gene rearrangement in leukaemia and lymphoma 109
- Modulation of developmental and transcription factor PAX genes by translocation 111
- The role of HOX genes in development, differentiation and neoplasia 113
- Chromosomal translocation, fusion proteins and tumour vascularisation 117
- Chromosomal translocations, fusion proteins and immunity 119
- The association of chromosomal translocation with fragile sites 120
- Chromosomal fragility, genetic loss and tumour suppressor genes 121
- Fragile histidine triad (FHIT) gene abnormalities in cancer 122
- Tumour suppressor function of von Hippel-Lindau gene 124
- The ras association domain family RASSF1 gene in tumour suppression 126
- Gene amplification and its relationship to genetic instability 126
- Chromosomal fragility and micronuclei 128
- DNA damage and the generation of micronuclei 128
- The involvement of p53 in the formation of micronuclei 129
- Centromeric instability, DNA methylation and micronuclei in ICF syndrome 130
- The nature and constitution of micronuclei 131
- 7 DNA methylation and genetic instability 133
- DNA methylation in normal and neoplastic development 133
- Abnormal DNA methylation in ICF and Rett syndromes 134
- DNA methylation and genetic instability 135
- The CpG Island Methylator Phenotype (CIMP) 136
- Influence of DNA methylation on recombination 139
- Methylation-associated chromosomal recombination and genetic transcription in childhood leukaemias 140
- The dynamics of histone acetylation in cell differentiation, cell proliferation and neoplasia 140
- Histone acetylation dynamics in development and differentiation 141
- Cell proliferation, apoptosis and histone acetylation dynamics 143
- Histone acetylation dynamics and the neoplastic process 144
- Synergistic effects of DNA methylation and histone acetylation dynamics on epigenetic gene silencing 147
- HDAC inhibitors in the treatment of cancer 148
- The effects of p53 methylation on chromosome stability 149
- DNA methylation in fragile X syndrome 151
- FMR1 gene function in the pathogenesis of fragile X syndrome 151
- Epigenetic silencing of FMR1 in fragile X syndrome 152
- 8 Telomeric DNA and genetic instability 154
- Telomeres and cell proliferation, apoptosis and cell senescence 154
- Telomeres in DNA repair 158
- Telomere function and ATM kinase 158
- Telomeric association 159
- The incidence of telomeric association in cancer 159
- Telomeric association and gene expression 161
- Telomere position effect 162.
- Notes:
- Includes bibliographical references (pages [170]-236) and index.
- ISBN:
- 012639881X
- OCLC:
- 156029901
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