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Erythropoietins and erythropoiesis : molecular, cellular, preclinical, and clinical biology / edited by G. Molineux, M.A. Foote, and S.G. Elliott.
Holman Biotech Commons QP96 .E79 2003
Available
- Format:
- Book
- Series:
- Milestones in drug therapy
- Language:
- English
- Subjects (All):
- Erythropoiesis.
- Erythropoietin.
- Recombinant erythropoietin.
- Anemia--Treatment.
- Anemia.
- Erythropoietin, Recombinant.
- Anemia--therapy.
- Medical Subjects:
- Erythropoiesis.
- Erythropoietin.
- Erythropoietin, Recombinant.
- Anemia--therapy.
- Physical Description:
- xi, 269 pages : illustrations (some color) ; 24 cm.
- Place of Publication:
- Basel ; New York : Birkhäuser Verlag, [2003]
- Summary:
- This volume is a one-source guide to the most current information about red blood cell formation and the action of recombinant human erythropoietins. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia will be covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. It is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.
- Contents:
- I. Background and basic science
- Erythropoiesis: an overview / Lyonel G. Israels, Esther D. Israels 3
- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin / MaryAnn Foote 15
- Structural basis for the signal transduction of erythropoietin / Timothy Osslund, Rashid Syed 25
- Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues / Christof Dame 35
- Erythropoietin receptor signaling processes / Saghi Ghaffari, Lily Jun-shen Huang, Jing Zhang, Harvey F. Lodish 65
- Clinical pharmacokinetic properties of rHuEPO: a review / Anne C. Heatherington 87
- Biology of erythropoietin / Graham Molineux 113
- Commercial production of recombinant erythropoietins / Alice S. Chuck, Rohini R. Deshpande, Adrian R. Distler, Shane A. Sander, James E. Seely 133
- II. Clinical use of recombinant erythropoietins
- Use of recombinant erythropoietins in the setting of renal disease / Iain C. Macdougall 153
- Erythropoietic therapy in the practice of oncology / John Glaspy 163
- Use of recombinant erythropoietins for the treatment of anemia of chronic disease / Robert T. Means, Jr. 185
- Use of erythropoietins in the surgical setting / Fred D. Cushner 197
- Abuse of recombinant erythropoietins by athletes / Don H. Catlin, Caroline K. Hatton, Francoise Lasne 205
- Antibodies to endogenous and recombinant erythropoietin / Patrick Mayeux, Nicole Casadevall 229
- New molecules and formulations of recombinant human erythropoietin / Steven G. Elliott 241.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 3764369191
- OCLC:
- 51983412
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